Other substances

Floxuridine

A pyrimidine monophosphate analogue.

Phase of research

Potential treatment - pre-clinical evidence

How it helps

Antiviral

Drug status

Used to treat other disease

1
 Supporting references
0
 Contradictory references
2
 AI-suggested references
0
 Clinical trials

General information

Floxuridine is a fluorinated pyrimidine monophosphate analogue. It inhibits thymidylate synthase and has antineoplastic properties (NCIt).

Floxuridine on DrugBank
Floxuridine on PubChem
Floxuridine on Wikipedia


Marketed as

FUDR

 

Structure image - Floxuridine

C1[C@@H]([C@H](O[C@H]1N2C=C(C(=O)NC2=O)F)CO)O


 

Supporting references

Link Tested on Impact factor Notes Publication date
Blockers of the SARS-CoV-2 3a Channel Identified by Targeted Drug Repurposing
Small molecule In vitro 		in vitro bacteria-based assay 3.82

Displayed inhibitory activity against the potential ion channel ORF3a of SARS-CoV-2 in a bacterial model assay.

 Mar/23/2021

AI-suggested references

Link Publication date
Molecular Docking and Dynamics Investigations for Identifying Potential Inhibitors of the 3-Chymotrypsin-like Protease of SARS-CoV-2: Repurposing of Approved Pyrimidonic Pharmaceuticals for COVID-19 Treatment.
May/29/2020
Repositioning anticancer drugs as novel COVID-19 antivirals: targeting structural and functional similarities between viral proteins and cancer
Apr/22/2022
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