Exosomal vaccine
A vesicle-based immunogen.
General information
Exosomes are a class of nano-sized cell-derived extracellular vesicles. They carry various types of natural or engineered cellular components or substances (Zhang et al., 2020). The term “exosomal vaccine” may refer to various cell-derived products whose biological activity is based on exosomal delivery of an immunogenic substance. Shen et al. (2022) showed the immunogenic potential of exosomes loaded with T cell epitope peptides derived from SARS-CoV-2 in mice. Wang et al. (2022) loaded lung-derived exosomes with recombinant SARS-CoV-2 receptor-binding domain. They showed the formulation’s efficacy in a SARS-CoV-2 pseudovirus challenge in a murine mode and in a SARS-CoV-2 live virus challenge in a hamster model.
Supporting references
| Link | Tested on | Impact factor | Notes | Publication date |
|---|---|---|---|---|
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Exosomal Vaccine Loading T Cell Epitope Peptides of SARS-CoV-2 Induces Robust CD8+ T Cell Response in HLA-A Transgenic Mice
Spike protein RdRpol Envelope protein Nucleocapsid protein Membrane protein Cell-based therapy Novel compound Animal model Mixed substance Extracellular vesicles |
"A patient with blastic plasmacytoid dendritic cell neoplasm" | 6.40 | Red blood cell-derived exosomes were loaded with SARS-CoV-2-derived peptides conjugated to molecules with affinity to lipides, which were previously found to be presented by human leukocyte antigen A0201 molecule. The formulation induced a CD8+ T cell response in mice without visible organ toxicity. |
Jul/29/2022 |
|
Exosomes decorated with a recombinant SARS-CoV-2 receptor-binding domain as an inhalable COVID-19 vaccine
Spike protein Cell-based therapy Novel compound Animal model In vitro Mixed substance Extracellular vesicles |
In vitro; male CD1 mice; Syrian golden hamsters | 25.67 | Lung cell-derived exosomes were conjugated with SARS-CoV-2 recombinant SARS-CoV-2 receptor-binding domain. The inhaled formulation induced a systematic immune response in mice, including mucosal IgA and lung T cell responses. It was shown to attenuate severe pneumonia and reduce inflammatory infiltrates in hamsters after a viral challenge. The exosomes were stable during storage. |
Jul/04/2022 |
