Other substances

Ethacrynic acid

A loop diuretic.

Phase of research

Potential treatment - pre-clinical evidence

How it helps

Antiviral

Drug status

Used to treat other disease

1
 Supporting references
0
 Contradictory references
1
 AI-suggested references
0
 Clinical trials

General information

Ethacrynic acid is a monosulfonamyl drug inhibiting sodium, potassium, and chloride symport. It acts primarily as a loop diuretic (DrugBank). It acts as a potent irreversible SARS-CoV-2 3C-like protease inhibitor in vitro (Isgrò et al., 2021).

Ethacrynic acid on PubChem
Ethacrynic acid on Wikipedia


Synonyms

Etacrinic acid; Etacrynic acid

Marketed as

CRINURYL; EDECRIL; EDECRINA; ENDECRIL; EDECRIN; EDECRIN SODIUM; ETHACRYNATE SODIUM; HIDROMEDIN; HYDROMEDIN; MINGIT; OTACRIL; REOMAX; TALADREN; UREGIT

 

Structure image - Ethacrynic acid

CCC(=C)C(=O)C1=C(C(=C(C=C1)OCC(=O)O)Cl)Cl

Supporting references

Link Tested on Impact factor Notes Publication date
Systematic Search for SARS-CoV-2 Main Protease Inhibitors for Drug Repurposing: Ethacrynic Acid as a Potential Drug
3CLpro Enzyme assay In vitro In silico 		in silico; in vitro enzyme assay 3.82

Inhibited the SARS-CoV-2 3C-like protease in vitro in concentrations which are cited to be achievable in human plasma and not to by cytotoxic.

 Jan/13/2021

AI-suggested references

Link Publication date
Repurposing existing drugs: identification of SARS-CoV-2 3C-like protease inhibitors
Jan/13/2021
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