Ergotamine
A natural serotonin (1D) and alpha-adrenergic receptor agonist.
General information
Ergotamine is a natural alkaloid vasoconstrictor and analgesic. It is used for treatment of headaches. Ergotamine might inhibit release of pro-inflamatory neuropeptides (NCIt).
Ergotamine on DrugBank
Ergotamine on PubChem
Ergotamine on Wikipedia
Marketed as
ERGOMAR (ERGOTAMINE TARTRATE); ANERVAN; ANTIMIGRAINE; ENXAK; ERGAM; ERGO-KRANIT; GYNAEMINE; GYNERGEN; WIGRETTES
C[C@@]1(C(=O)N2[C@H](C(=O)N3CCC[C@H]3[C@@]2(O1)O)CC4=CC=CC=C4)NC(=O)[C@H]5CN([C@@H]6CC7=CNC8=CC=CC(=C78)C6=C5)C
Supporting references
| Link | Tested on | Impact factor | Notes | Publication date |
|---|---|---|---|---|
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In silico identification of widely used and well-tolerated drugs as potential SARS-CoV-2 3C-like protease and viral RNA-dependent RNA polymerase inhibitors for direct use in clinical trials
|
in silico | 3.31 | Aug/05/2020 | |
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In silico screening of FDA approved drugs reveals ergotamine and dihydroergotamine as potential coronavirus main protease enzyme inhibitors
3CLpro Small molecule In silico |
in silico | 2.80 | Predicted potent binding to the catalytic site of the SARS-CoV-2 3C-like protease. |
Jun/10/2020 |
|
Identification and characterization of novel RdRp and Nsp15 inhibitors for SARS-COV2 using computational approach
RdRpol nsp15 Small molecule In silico |
in silico | 3.22 | Predicted to inhibit the SARS-CoV-2 RNA-dependent RNA polymerase and nsp15 protein. |
Nov/05/2020 |
