Epigallocatechin Gallate

A phenolic antioxidant.

Phase of research

Potential treatment - pre-clinical evidence

How it helps


Drug status

Natural product

Supporting references
Contradictory references
AI-suggested references
Clinical trials

General information

Epigallocatechin Gallate is a natural antioxidant. Benefits of its use in cancer therapy have been investigated (NCIt)

Epigallocatechin Gallate on DrugBank
Epigallocatechin Gallate on PubChem
Epigallocatechin Gallate on Wikipedia


Epigallocatechin-3-gallate; (-)-Epigallocatechin gallate; EGCG; NuBBE-242


Structure image - Epigallocatechin Gallate


Supporting references

Link Tested on Impact factor Notes Publication date
Evaluation of Flavonoids as 2019-nCoV Cell Entry Inhibitor Through Molecular Docking and Pharmacological Analysis
Preprint In silico
in silico Apr/06/2020
Epigallocatechin gallate and theaflavin gallate interaction in SARS‐CoV‐2 spike‐protein central channel with reference to the hydroxychloroquine interaction: Bioinformatics and molecular docking study
Spike protein Small molecule In silico
in silico 1.90

Predicted to bind SARS-CoV-2 spike protein central channel (better than hydroxychloroquine).

Searching potential antiviral candidates for the treatment of the 2019 novel coronavirus based on DFT calculations and molecular docking
Small molecule In silico
in silico 1.65

Predicted to have inhibitory physical interactions with SARS-CoV-2 structures.

Tea Polyphenols EGCG and Theaflavin Inhibit the Activity of SARS-CoV-2 3CL-Protease In Vitro
3CLpro Small molecule Enzyme assay In vitro
in vitro enzyme assay; HEK293T (cytotoxicity) 1.81

Inhibited the SARS-CoV-2 3C-like protease in vitro at non-cytotoxic levels.

Targeting the GRP78-Dependant SARS-CoV-2 Cell Entry by Peptides and Small Molecules
Small molecule Peptide In silico
in silico 1.31

Predicted to bind the SARS-CoV-2 spike protein and glucose-regulating protein 78 receptor.

Identification of Persuasive Antiviral Natural Compounds for COVID-19 by Targeting Endoribonuclease NSP15: A Structural-Bioinformatics Approach
nsp15 Small molecule In silico
in silico 3.27

Predicted to bind SARS-CoV-2 endoribonuclease (nsp15).

A molecular docking study of EGCG and theaflavin digallate with the druggable targets of SARS-CoV-2
Small molecule In silico
in silico 3.43

Predicted to target multiple SARS-CoV-2 factors.

The inhibitory effects of PGG and EGCG against the SARS-CoV-2 3C-like protease
Small molecule Enzyme assay In vitro In silico
in silico; in vitro enzyme assay 2.99

Inhibits the SARS-CoV-2 3C-like protease with IC50 of ca. 4.24 μM in vitro. It was computationally predicted to bind the protease's active site.

Epigallocatechin-3-gallate, an active ingredient of Traditional Chinese Medicines, inhibits the 3CLpro activity of SARS-CoV-2
3CLpro Biophysical assay Small molecule Enzyme assay In vitro In silico
in silico; in vitro enzyme assay; in vitro biophysical assay 5.16

Interacted with and inhibited SARS-CoV-2 3C-like protease with an IC50 of ca. 0.874 μM in vitro.

EGCG, a Green Tea Catechin, as a Potential Therapeutic Agent for Symptomatic and Asymptomatic SARS-CoV-2 Infection
PapainLpro Small molecule In silico
in silico 3.27

Predicted to inhibit SARS-CoV-2 Papain-like protease.

The green tea catechin epigallocatechin gallate inhibits SARS-CoV-2 infection
Spike protein ACE2 Small molecule In vitro
HEK293T-hACE2 cells; (HIV-1) SARS-CoV-2 Spike-pseudotyped virus; SARS-CoV-2 isolate MUC-IMB-1 3.38

The compound inhibited SARS-CoV-2 pseudotyped virus infection and replication in HEK293T-ACE2 cells with an IC50 of 3.14 μM. It inhibited ACE2-RBD (SARS-CoV-2 Spike) interaction in vitro.


AI-suggested references

Link Publication date
Oolong tea extract alleviates weight gain in high-fat diet-induced obese rats by regulating lipid metabolism and modulating gut microbiota.
Polygoni multiflori radix extracts inhibit SARS-CoV-2 pseudovirus entry in HEK293T cells and zebrafish larvae.
Research progress of epigallocatechin-3-gallate (EGCG) on anti-pathogenic microbes and immune regulation activities.
Study on the mechanism of active components of Liupao tea on 3CLpro based on HPLC-DAD fingerprint and molecular docking technique.
Epigallocatechin Gallate (EGCG), a Green Tea Polyphenol, Reduces Coronavirus Replication in a Mouse Model.
Potential of Plant Bioactive Compounds as SARS-CoV-2 Main Protease (Mpro) and Spike (S) Glycoprotein Inhibitors: A Molecular Docking Study.
In silico analysis of echinocandins binding to the main proteases of coronaviruses PEDV (3CLpro) and SARS-CoV-2 (Mpro).
Antiviral Effects of Green Tea EGCG and Its Potential Application against COVID-19
Epigallocatechin gallate and theaflavin gallate interaction in SARS-CoV-2 spike-protein central channel with reference to the hydroxychloroquine interaction: Bioinformatics and molecular docking study
EGCG, a green tea polyphenol, inhibits human coronavirus replication in vitro.
Potential protective mechanisms of green tea polyphenol EGCG against COVID-19.
Identification of natural compounds as SARS-CoV-2 entry inhibitors by molecular docking-based virtual screening with bio-layer interferometry.
A Review of Medicinal Plants with Antiviral Activity Available in Bangladesh and Mechanistic Insight Into Their Bioactive Metabolites on SARS-CoV-2, HIV and HBV.
Assessment of Antioxidant, Immunomodulatory Activity of Oxidised Epigallocatechin-3-Gallate (Green Tea Polyphenol) and Its Action on the Main Protease of SARS-CoV-2:An In Vitro and In Silico Approach
Evaluation of green tea polyphenols as novel corona virus (SARS CoV-2) main protease (Mpro) inhibitors - an in silico docking and molecular dynamics simulation study
Epigallocatechin-3-Gallate (EGCG) Inhibits SARS-CoV-2 Infection in Primate Epithelial Cells: (A Short Communication).
Repurposing drugs and identification of inhibitors of integral proteins (spike protein and main protease) of SARS-CoV-2
Oridonin Inhibits SARS-CoV-2 by Targeting Its 3C-Like Protease.
Reynoutria Rhizomes as a Natural Source of SARS-CoV-2 Mpro Inhibitors-Molecular Docking and In Vitro Study
The potential of BEN815 as an anti-inflammatory, antiviral and antioxidant agent for the treatment of COVID-19.
Novel antiviral effects of chloroquine, hydroxychloroquine, and green tea catechins against SARS-CoV-2 main protease and 3C-like protease for COVID-19 treatment
Plant-derived natural polyphenols as potential antiviral drugs against SARS-CoV-2 via RNA-dependent RNA polymerase (RdRp) inhibition: an in-silico analysis
Entry-inhibitory role of catechins against SARS-CoV-2 and its UK variant.
In-silico drug repurposing for targeting SARS-CoV-2 main protease (Mpro)
Epigallocatechin Gallate Inhibits the Uridylate-Specific Endoribonuclease Nsp15 and Efficiently Neutralizes the SARS-CoV-2 Strain
Docking Characterization and in vitro Inhibitory Activity of Flavan-3-ols and Dimeric Proanthocyanidins Against the Main Protease Activity of SARS-Cov-2
Roles of flavonoids against coronavirus infection.
EGCG as an anti-SARS-CoV-2 agent: Preventive versus therapeutic potential against original and mutant virus
SARS-CoV-2 neutralizing activity of polyphenols in a special green tea extract preparation
Protective Effect of Epigallocatechin-3-Gallate (EGCG) in Diseases with Uncontrolled Immune Activation: Could Such a Scenario Be Helpful to Counteract COVID-19?
Food phytochemicals, epigallocatechin gallate and myricetin, covalently bind to the active site of the coronavirus main protease in vitro.
Identification of potential natural inhibitors of the receptor-binding domain of the SARS-CoV-2 spike protein using a computational docking approach
Green Tea Polyphenol Catechins Inhibit Coronavirus Replication and Potentiate the Adaptive Immunity and Autophagy-Dependent Protective Mechanism to Improve Acute Lung Injury in Mice.
Significant Inactivation of SARS-CoV-2 In Vitro by a Green Tea Catechin, a Catechin-Derivative, and Black Tea Galloylated Theaflavins.
Anti-SARS-CoV-2 activity of various PET-bottled Japanese green teas and tea compounds in vitro
In silico Nigellidine (N. sativa) bind to viral spike/active-sites of ACE1/2, AT1/2 to prevent COVID-19 induced vaso-tumult/vascular-damage/comorbidity.
Epigallocatechin gallate from green tea effectively blocks infection of SARS-CoV-2 and new variants by inhibiting spike binding to ACE2 receptor.
Flavonoids as potential phytotherapeutics to combat cytokine storm in SARS-CoV-2