Other substances

Epigallocatechin Gallate

A phenolic antioxidant.

Phase of research

Potential treatment - pre-clinical evidence

How it helps

Antiviral

Drug status

Natural product

Supporting references

Contradictory references

AI-suggested references

Clinical trials

General information

Epigallocatechin Gallate is a natural antioxidant. Benefits of its use in cancer therapy have been investigated (NCIt)

Epigallocatechin Gallate on DrugBank
Epigallocatechin Gallate on PubChem
Epigallocatechin Gallate on Wikipedia

Synonyms

Epigallocatechin-3-gallate; (-)-Epigallocatechin gallate; EGCG; NuBBE-242

Structure image - Epigallocatechin Gallate

C1[C@H]([C@H](OC2=CC(=CC(=C21)O)O)C3=CC(=C(C(=C3)O)O)O)OC(=O)C4=CC(=C(C(=C4)O)O)O

Supporting references

Link	Tested on	Impact factor	Notes	Publication date
Evaluation of Flavonoids as 2019-nCoV Cell Entry Inhibitor Through Molecular Docking and Pharmacological Analysis Preprint In silico	in silico			Apr/06/2020
Epigallocatechin gallate and theaflavin gallate interaction in SARS‐CoV‐2 spike‐protein central channel with reference to the hydroxychloroquine interaction: Bioinformatics and molecular docking study Spike protein Small molecule In silico	in silico	1.90	Predicted to bind SARS-CoV-2 spike protein central channel (better than hydroxychloroquine).	Aug/07/2020
Searching potential antiviral candidates for the treatment of the 2019 novel coronavirus based on DFT calculations and molecular docking Small molecule In silico	in silico	1.65	Predicted to have inhibitory physical interactions with SARS-CoV-2 structures.	Aug/01/2020
Tea Polyphenols EGCG and Theaflavin Inhibit the Activity of SARS-CoV-2 3CL-Protease In Vitro 3CLpro Small molecule Enzyme assay In vitro	in vitro enzyme assay; HEK293T (cytotoxicity)	1.81	Inhibited the SARS-CoV-2 3C-like protease in vitro at non-cytotoxic levels.	Sep/17/2020
Targeting the GRP78-Dependant SARS-CoV-2 Cell Entry by Peptides and Small Molecules Small molecule Peptide In silico	in silico	1.31	Predicted to bind the SARS-CoV-2 spike protein and glucose-regulating protein 78 receptor.	Oct/21/2020
Identification of Persuasive Antiviral Natural Compounds for COVID-19 by Targeting Endoribonuclease NSP15: A Structural-Bioinformatics Approach nsp15 Small molecule In silico	in silico	3.27	Predicted to bind SARS-CoV-2 endoribonuclease (nsp15).	Dec/01/2020
A molecular docking study of EGCG and theaflavin digallate with the druggable targets of SARS-CoV-2 Small molecule In silico	in silico	3.43	Predicted to target multiple SARS-CoV-2 factors.	Nov/23/2020
The inhibitory effects of PGG and EGCG against the SARS-CoV-2 3C-like protease Small molecule Enzyme assay In vitro In silico	in silico; in vitro enzyme assay	2.99	Inhibits the SARS-CoV-2 3C-like protease with IC50 of ca. 4.24 μM in vitro. It was computationally predicted to bind the protease's active site.	Jan/06/2021
Epigallocatechin-3-gallate, an active ingredient of Traditional Chinese Medicines, inhibits the 3CLpro activity of SARS-CoV-2 3CLpro Biophysical assay Small molecule Enzyme assay In vitro In silico	in silico; in vitro enzyme assay; in vitro biophysical assay	5.16	Interacted with and inhibited SARS-CoV-2 3C-like protease with an IC50 of ca. 0.874 μM in vitro.	Feb/04/2021
EGCG, a Green Tea Catechin, as a Potential Therapeutic Agent for Symptomatic and Asymptomatic SARS-CoV-2 Infection PapainLpro Small molecule In silico	in silico	3.27	Predicted to inhibit SARS-CoV-2 Papain-like protease.	Feb/24/2021
The green tea catechin epigallocatechin gallate inhibits SARS-CoV-2 infection Spike protein ACE2 Small molecule In vitro	HEK293T-hACE2 cells; (HIV-1) SARS-CoV-2 Spike-pseudotyped virus; SARS-CoV-2 isolate MUC-IMB-1	3.38	The compound inhibited SARS-CoV-2 pseudotyped virus infection and replication in HEK293T-ACE2 cells with an IC50 of 3.14 μM. It inhibited ACE2-RBD (SARS-CoV-2 Spike) interaction in vitro.	Apr/08/2021

AI-suggested references

Link	Publication date
Oolong tea extract alleviates weight gain in high-fat diet-induced obese rats by regulating lipid metabolism and modulating gut microbiota.	Mar/07/2022
Polygoni multiflori radix extracts inhibit SARS-CoV-2 pseudovirus entry in HEK293T cells and zebrafish larvae.	May/25/2021
Research progress of epigallocatechin-3-gallate (EGCG) on anti-pathogenic microbes and immune regulation activities.	Oct/19/2021
Study on the mechanism of active components of Liupao tea on 3CLpro based on HPLC-DAD fingerprint and molecular docking technique.	Jul/05/2021
Epigallocatechin Gallate (EGCG), a Green Tea Polyphenol, Reduces Coronavirus Replication in a Mouse Model.	Jan/07/2021
Potential of Plant Bioactive Compounds as SARS-CoV-2 Main Protease (Mpro) and Spike (S) Glycoprotein Inhibitors: A Molecular Docking Study.	Dec/23/2020
In silico analysis of echinocandins binding to the main proteases of coronaviruses PEDV (3CLpro) and SARS-CoV-2 (Mpro).	Jul/01/2021
Antiviral Effects of Green Tea EGCG and Its Potential Application against COVID-19	Apr/11/2021
Epigallocatechin gallate and theaflavin gallate interaction in SARS-CoV-2 spike-protein central channel with reference to the hydroxychloroquine interaction: Bioinformatics and molecular docking study	Aug/07/2020
EGCG, a green tea polyphenol, inhibits human coronavirus replication in vitro.	Feb/10/2021
Potential protective mechanisms of green tea polyphenol EGCG against COVID-19.	May/25/2021
Identification of natural compounds as SARS-CoV-2 entry inhibitors by molecular docking-based virtual screening with bio-layer interferometry.	Aug/14/2021
A Review of Medicinal Plants with Antiviral Activity Available in Bangladesh and Mechanistic Insight Into Their Bioactive Metabolites on SARS-CoV-2, HIV and HBV.	Nov/08/2021
Assessment of Antioxidant, Immunomodulatory Activity of Oxidised Epigallocatechin-3-Gallate (Green Tea Polyphenol) and Its Action on the Main Protease of SARS-CoV-2:An In Vitro and In Silico Approach	Dec/01/2020
Evaluation of green tea polyphenols as novel corona virus (SARS CoV-2) main protease (Mpro) inhibitors - an in silico docking and molecular dynamics simulation study	Jun/22/2020
Epigallocatechin-3-Gallate (EGCG) Inhibits SARS-CoV-2 Infection in Primate Epithelial Cells: (A Short Communication).	Mar/14/2022
Repurposing drugs and identification of inhibitors of integral proteins (spike protein and main protease) of SARS-CoV-2	Apr/15/2020
Oridonin Inhibits SARS-CoV-2 by Targeting Its 3C-Like Protease.	Mar/13/2022
Reynoutria Rhizomes as a Natural Source of SARS-CoV-2 Mpro Inhibitors-Molecular Docking and In Vitro Study	Jul/29/2021
The potential of BEN815 as an anti-inflammatory, antiviral and antioxidant agent for the treatment of COVID-19.	Mar/18/2021
Novel antiviral effects of chloroquine, hydroxychloroquine, and green tea catechins against SARS-CoV-2 main protease and 3C-like protease for COVID-19 treatment	Sep/13/2021
Plant-derived natural polyphenols as potential antiviral drugs against SARS-CoV-2 via RNA-dependent RNA polymerase (RdRp) inhibition: an in-silico analysis	Jul/28/2020
Entry-inhibitory role of catechins against SARS-CoV-2 and its UK variant.	Jun/10/2021
In-silico drug repurposing for targeting SARS-CoV-2 main protease (Mpro)	Feb/06/2022
Epigallocatechin Gallate Inhibits the Uridylate-Specific Endoribonuclease Nsp15 and Efficiently Neutralizes the SARS-CoV-2 Strain	May/21/2021
Docking Characterization and in vitro Inhibitory Activity of Flavan-3-ols and Dimeric Proanthocyanidins Against the Main Protease Activity of SARS-Cov-2	Nov/30/2020
Roles of flavonoids against coronavirus infection.	Jul/28/2020
EGCG as an anti-SARS-CoV-2 agent: Preventive versus therapeutic potential against original and mutant virus	Aug/10/2021
SARS-CoV-2 neutralizing activity of polyphenols in a special green tea extract preparation	Jun/22/2020
Protective Effect of Epigallocatechin-3-Gallate (EGCG) in Diseases with Uncontrolled Immune Activation: Could Such a Scenario Be Helpful to Counteract COVID-19?	Jul/21/2020
Food phytochemicals, epigallocatechin gallate and myricetin, covalently bind to the active site of the coronavirus main protease in vitro.	Oct/08/2021
Identification of potential natural inhibitors of the receptor-binding domain of the SARS-CoV-2 spike protein using a computational docking approach	Aug/21/2020
Green Tea Polyphenol Catechins Inhibit Coronavirus Replication and Potentiate the Adaptive Immunity and Autophagy-Dependent Protective Mechanism to Improve Acute Lung Injury in Mice.	Jun/07/2021
Significant Inactivation of SARS-CoV-2 In Vitro by a Green Tea Catechin, a Catechin-Derivative, and Black Tea Galloylated Theaflavins.	Jun/11/2021
Anti-SARS-CoV-2 activity of various PET-bottled Japanese green teas and tea compounds in vitro	May/24/2022
In silico Nigellidine (N. sativa) bind to viral spike/active-sites of ACE1/2, AT1/2 to prevent COVID-19 induced vaso-tumult/vascular-damage/comorbidity.	Mar/18/2021
Epigallocatechin gallate from green tea effectively blocks infection of SARS-CoV-2 and new variants by inhibiting spike binding to ACE2 receptor.	Aug/30/2021
Flavonoids as potential phytotherapeutics to combat cytokine storm in SARS-CoV-2	Mar/29/2020

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