Other substances

Emodin

An anthraquinone.

Phase of research

Potential treatment - theoretical effect

How it helps

Antiviral

Drug status

Used to treat other disease

Supporting references

Contradictory references

AI-suggested references

Clinical trials

General information

Emodin is an anthraquinone plant metabolite found in Traditional Chinese Medicine. It is a tyrosine kinase inhibitor, an antineoplastic agent, and a laxative (ChEBI).

Emodin on DrugBank
Emodin on PubChem
Emodin on Wikipedia

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Supporting references

Link	Tested on	Impact factor	Notes	Publication date
Network-based drug repurposing for novel coronavirus 2019-nCoV/SARS-CoV-2	in silico		in combination with toremifene	Mar/16/2020
In silico screening of hundred phytocompounds of ten medicinal plants as potential inhibitors of nucleocapsid phosphoprotein of COVID-19: an approach to prevent virus assembly Nucleocapsid protein Small molecule In silico	in silico	3.22	Predicted to inhibit the SARS-CoV-2 nucleocapsid protein.	Aug/27/2020
Molecular docking study of potential phytochemicals and their effects on the complex of SARS-CoV2 spike protein and human ACE2 Spike protein ACE2 Small molecule In silico	in silico	4.00	Predicted to bind the host ACE2 receptor in complex with the spike protein of SARS-CoV-2.	Oct/19/2020

AI-suggested references

Link	Publication date
Natural Products: A Rich Source of Antiviral Drug Lead Candidates for the Management of COVID-19.	Nov/21/2020
Feasibility analysis and mechanism exploration of Rhei Radix et Rhizome-Schisandrae Sphenantherae Fructus (RS) against COVID-19.	May/19/2022
Molecular docking and dynamics study to explore phytochemical ligand molecules against the main protease of SARS-CoV-2 from extensive phytochemical datasets.	Aug/05/2021
In Silico Studies Reveal Antiviral Effects of Traditional Indian Spices on COVID-19.	Dec/29/2020
Drugs repurposed for COVID-19 by virtual screening of 6,218 drugs and cell-based assay	Sep/07/2021
Computational studies reveal mechanism by which quinone derivatives can inhibit SARS-CoV-2. Study of embelin and two therapeutic compounds of interest, methyl prednisolone and dexamethasone.	Oct/14/2020
Reynoutria Rhizomes as a Natural Source of SARS-CoV-2 Mpro Inhibitors-Molecular Docking and In Vitro Study	Jul/29/2021
In Silico Screening of Natural Products Isolated from Mexican Herbal Medicines against COVID-19	Mar/15/2021
Phytocompounds of Rheum emodi, Thymus serpyllum, and Artemisia annua Inhibit Spike Protein of SARS-CoV-2 Binding to ACE2 Receptor: In Silico Approach.	Jul/15/2021
Revealing the therapeutic targets and molecular mechanisms of emodin-treated coronavirus disease 2019 via a systematic study of network pharmacology	Jun/04/2021
A hijack mechanism of Indian SARS-CoV-2 isolates for relapsing contemporary antiviral therapeutics.	Mar/06/2021
In Silico Screening of Natural Products as Potential Inhibitors of SARS-CoV-2 Using Molecular Docking Simulation	Mar/15/2022
Therapeutic potential of medicinal plants against COVID-19: The role of antiviral medicinal metabolites.	Dec/11/2020
Antiviral Activities of Halogenated Emodin Derivatives against Human Coronavirus NL63	Jun/21/2021
Amantadine inhibits known and novel ion channels encoded by SARS-CoV-2 in vitro	Dec/01/2021
Identification of potential SARS-CoV-2 entry inhibitors by targeting the interface region between the spike RBD and human ACE2.	Dec/21/2020
Exploration of the Mechanism of Lianhua Qingwen in Treating Influenza Virus Pneumonia and New Coronavirus Pneumonia with the Concept of "Different Diseases with the Same Treatment" Based on Network Pharmacology	May/25/2021

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