Other substances

(E)-N-[4-[3-Chloro-4-[(3-fluorophenyl)methoxy]anilino]-3-cyano-7-ethoxyquinolin-6-yl]-4-(dimethylamino)but-2-enamide

A 4-aminoquinoline.

Phase of research

Potential treatment - theoretical effect

How it helps

Antiviral

Drug status

Experimental

1
 Supporting references
0
 Contradictory references
0
 AI-suggested references
0
 Clinical trials

General information

(E)-N-[4-[3-Chloro-4-[(3-fluorophenyl)methoxy]anilino]-3-cyano-7-ethoxyquinolin-6-yl]-4-(dimethylamino)but-2-enamide on PubChem

Synonyms

HKI-375

 

Structure image - (E)-N-[4-[3-Chloro-4-[(3-fluorophenyl)methoxy]anilino]-3-cyano-7-ethoxyquinolin-6-yl]-4-(dimethylamino)but-2-enamide

CCOC1=C(C=C2C(=C1)N=CC(=C2NC3=CC(=C(C=C3)OCC4=CC(=CC=C4)F)Cl)C#N)NC(=O)/C=C/CN(C)C

Supporting references

Link Tested on Impact factor Notes Publication date
Potential clinical drugs as covalent inhibitors of the priming proteases of the spike protein of SARS-CoV-2
TMPRSS2 Cathepsin B Cathepsin L Small molecule In silico 		in silico 6.02

Predicted to inhibit the host cathepsin B and L proteases and thereby inhibit the SAS-CoV-2 entry.

 Aug/26/2020
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