Other substances

Dronedarone

An 1-benzofuran antiarrhythmic drug.

Phase of research

Potential treatment - pre-clinical evidence

How it helps

Antiviral

Drug status

Used to treat other disease

2
 Supporting references
0
 Contradictory references
0
 AI-suggested references
0
 Clinical trials

General information

Dronedarone is an amiodarone derivate. It is used as an antiarrhythmic drug based on its inhibitory activity against multiple ion channels. It can produce liver-related side effects (LiverTox; DrugBank).

Dronedarone was observed to inhibit the SARS-CoV-2 Papain-like protease in vitro (Jan et al., 2021).

Dronedarone on PubChem
Dronedarone on Wikipedia


Marketed as

MULTAQ

 

Structure image - Dronedarone

CCCCC1=C(C2=C(O1)C=CC(=C2)NS(=O)(=O)C)C(=O)C3=CC=C(C=C3)OCCCN(CCCC)CCCC

Supporting references

Link Tested on Impact factor Notes Publication date
Identification of Potent and Safe Antiviral Therapeutic Candidates Against SARS-CoV-2
Small molecule In vitro Screening 		Vero cells 5.09 Nov/25/2020
Identification of existing pharmaceuticals and herbal medicines as inhibitors of SARS-CoV-2 infection
3CLpro PapainLpro Enzyme assay Animal model In vitro In silico 		in silico; in vitro enzyme assay; Vero E6 cells; golden Syrian hamsters; SARS-CoV-2 clinical isolate hCoV-19/Taiwan/4/2020 9.41

Inhibited SARS-CoV-2 infection in Vero E6 cells. Inhibited SARS-CoV-2 Papain-like protease in vitro.

 Jan/15/2021
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