DREP-S
A candite DNA-based COVID-19 vaccine.
General information
DREP-S is a candidate DNA-launched self-amplifying replicon RNA vector vaccine based on Semliki Forest virus genome. It encodes viral RNA replicase and an antigen (SARS-CoV-2 Wuhan-Hu-1 strain Spike protein with an 18-amino acid deletion in the cytoplasmic tail) but lacks the genes for structural proteins. The vaccines self-amplifying activity results in adjuvant properties (Szurgot et al., 2021).
Supporting references
| Link | Tested on | Impact factor | Notes | Publication date |
|---|---|---|---|---|
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DNA-launched RNA replicon vaccines induce potent anti-SARS-CoV-2 immune responses in mice
Spike protein DNA Animal model In vitro |
in vitro binding assay; HEK293T cells; HEK293T-ACE2 cells; C57BL/6J mice | 4.00 | Immunization in mice elicited potent anti-SARS-CoV-2 IgG (Th1 biased), neutralizing antibody, and T cell responses. The murine antibodies neutralized SARS-CoV-2 pseudotyped virus in vitro. This vaccine can be further boosted with heterologous Spike protein immunization. |
Feb/04/2021 |
