Other substances

Doxorubicin

An anthracycline antibiotic.

Phase of research

Potential treatment - theoretical effect

How it helps

Antiviral

Drug status

Used to treat other disease

Supporting references

Contradictory references

AI-suggested references

Clinical trials

General information

Doxorubicin on PubChem

Marketed as

DOXORUBICIN HYDROCHLORIDE; DOXIL (LIPOSOMAL) (DOXORUBICIN HYDROCHLORIDE)

C[C@H]1[C@H]([C@H](C[C@@H](O1)O[C@H]2C[C@@](CC3=C2C(=C4C(=C3O)C(=O)C5=C(C4=O)C(=CC=C5)OC)O)(C(=O)CO)O)N)O

Supporting references

Link	Tested on	Impact factor	Notes	Publication date
Repurposing approved drugs as potential inhibitors of 3CL-protease of SARS-CoV-2: Virtual screening and structure based drug design 3CLpro Small molecule In silico Screening	in silico	1.85	Predicted to inhibit SARS-CoV-2 3C-like protease.	Jul/31/2020

AI-suggested references

Link	Publication date
Discovery of new drug indications for COVID-19: A drug repurposing approach.	May/06/2021
Safety and efficacy of a dose-dense short-term therapy in patients with MYC-translocated aggressive lymphoma.	Jan/19/2022
Basophil reactivity to BNT162b2 is mediated by PEGylated lipid nanoparticles in patients with PEG allergy.	May/12/2021
Topoisomerase 2 inhibitor etoposide promotes interleukin-10 production in LPS-induced macrophages via upregulating transcription factor Maf and activating PI3K/Akt pathway.	Oct/07/2020
Development and optimization of a high-throughput screening assay for in vitro anti-SARS-CoV-2 activity: Evaluation of 5676 Phase 1 Passed Structures Development and optimization of a high-throughput screening assay for in vitro anti-SARS-CoV-2 activity:	May/07/2022
Synthesis and Cytotoxic Activity of Novel Indole Derivatives and Their in silico Screening on Spike Glycoprotein of SARS-CoV-2	Dec/30/2021
Vulnerabilities of the SARS-CoV-2 Virus to Proteotoxicity-Opportunity for Repurposed Chemotherapy of COVID-19 Infection.	Oct/09/2020
Zinc-Loaded Black Phosphorus Multifunctional Nanodelivery System Combined With Photothermal Therapy Have the Potential to Treat Prostate Cancer Patients Infected With COVID-19	Jan/19/2021
Synthesis and in vitro Study of Artemisinin/Synthetic Peroxide-Based Hybrid Compounds against SARS-CoV-2 and Cancer	Apr/06/2021
Phase I feasibility study of Magnetic Resonance guided High Intensity Focused Ultrasound-induced hyperthermia, Lyso-Thermosensitive Liposomal Doxorubicin and cyclophosphamide in de novo stage IV breast cancer patients: study protocol of the i-GO study	Oct/12/2021
Therapeutic development by repurposing drugs targeting SARS-CoV-2 spike protein interactions by simulation studies	Apr/28/2021
Ixazomib-based frontline therapy in patients with newly diagnosed multiple myeloma in real-life practice showed comparable efficacy and safety profile with those reported in clinical trial: a multi-center study	Sep/06/2020
Identification of doxorubicin as a potential therapeutic against SARS-CoV-2 (COVID-19) protease: a molecular docking and dynamics simulation studies	Jun/23/2021
COVID-19-Associated Pneumonia in a B-Cell-Depleted Patient With Non-Hodgkin Lymphoma: Recovery With Hyperimmune Plasma	Apr/22/2022
Design and synthesis of heterocyclic azole based bioactive compounds: Molecular structures, quantum simulation, and mechanistic studies through docking as multi-target inhibitors of SARS-CoV-2 and cytotoxicity	Nov/18/2020

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