Other substances

Diphyllin

A lignan.

Phase of research

Potential treatment - pre-clinical evidence

How it helps

Antiviral

Drug status

Natural product

1
 Supporting references
0
 Contradictory references
0
 AI-suggested references
0
 Clinical trials

General information

Diphyllin is a natural compound, which acts as a V-ATPase inhibitor (Sørensen et al., 2009).

Diphyllin on PubChem

 

Structure image - Diphyllin

COC1=C(C=C2C(=C1)C(=C3C(=C2O)COC3=O)C4=CC5=C(C=C4)OCO5)OC

Supporting references

Link Tested on Impact factor Notes Publication date
Antiviral Activity of Vacuolar ATPase Blocker Diphyllin against SARS-CoV-2
Small molecule In vitro 		Vero cells; Vero E6 cells; Caco-2 cells; SARS-CoV-2 strain SARS-CoV-2/human/Czech Republic/951/2020 4.15

Reduced SARS-CoV-2 plaque counts in Vero cells with an EC50 of ca. 1.92 μM and an SI of >52.08. In Caco-2 cells the compound’s cytotoxicity was higher and it moderately reduced SARS-CoV-2 multiplication at 1.5 μM (1 order of magnitude) and 3 μM (2 orders of magnitude) concentrations. The compound's solubility in water is low, however.

 Feb/25/2021
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