Other substances

Diltiazem

A bezothiazepine calcium channel blocker.

Phase of research

Potential treatment - pre-clinical evidence

How it helps

Antiviral

Drug status

Used to treat other disease

1
 Supporting references
0
 Contradictory references
2
 AI-suggested references
1
 Clinical trials

General information

Diltiazem is a benzothiazepine calcium channel blocker. It has antiarrhythmic and anti-hypertensive properties (NCIt).

Diltiazem on DrugBank
Diltiazem on PubChem
Diltiazem on Wikipedia

Marketed as

As diltiazem hydrochloride (CARDIZEM; CARTIA XT; DILACOR XR; TAZTIA XT; TIAZAC)

 

Structure image - Diltiazem

CC(=O)O[C@@H]1[C@@H](SC2=CC=CC=C2N(C1=O)CCN(C)C)C3=CC=C(C=C3)OC

Supporting references

Link Tested on Impact factor Notes Publication date
Characterization and Treatment of SARS-CoV-2 in Nasal and Bronchial Human Airway Epithelia
Small molecule In vitro 		Vero E6 cells; human airway epithelia cultured cells

Potentiates the efficacy of remdesivir monotherapy in human epithelial airway cells in vitro.

 Jul/21/2020

AI-suggested references

Link Publication date
Diltiazem inhibits SARS-CoV-2 cell attachment and internalization and decreases the viral infection in mouse lung
Feb/17/2022
In vitro evaluation of antiviral activity of single and combined repurposable drugs against SARS-CoV-2
Jul/15/2020

Clinical trials

ID Title Status Phase Start date Completion date
NCT04372082 Hydroxychloroquine or Diltiazem-Niclosamide for the Treatment of COVID-19 Withdrawn Phase 3 May/01/2020 May/01/2023
  • Alternative id - 2020_40|2020-002188-72
  • Interventions - Other: Standard of care (SOC)|Drug: Hydroxychloroquine|Drug: Association of diltiazem and niclosamide
  • Study type - Interventional
  • Study results - No Results Available
  • Locations -
  • Study designs - Allocation: Randomized|Intervention Model: Parallel Assignment|Masking: Single (Investigator)|Primary Purpose: Treatment
  • Enrollment - 0
  • Age - 18 Years and older   (Adult, Older Adult)
  • Outcome measures - death|clinical worsening (composite criteria)|Assisted-ventilation and/or hospitalization (composite criteria)|National Early Warning Score (NEWS)|cumulative incidence of hospitalizations|cumulative incidence of the use of oxygen therapy, non-invasive ventilation or invasive ventilation ( composite criteria)|Mortality|cumulative incidence of viral shedding on SARS-CoV-2 rt-PCR on nasopharyngeal swab;|adverse drug reactions
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