Other substances

Dihydromyricetin

An alpha-hydroxy ketone.

Phase of research

Potential treatment - pre-clinical evidence

How it helps

Antiviral

Drug status

Natural product

1
 Supporting references
0
 Contradictory references
4
 AI-suggested references
0
 Clinical trials

General information

Dihydromyricetin is a pant metabolite (Liu et al., 2021) with potential antioxidant, antineoplastic (ChEBI) and anticoronoviral properties (Liu et al., 2021).

Dihydromyricetin on DrugBank
Dihydromyricetin on PubChem
Dihydromyricetin on Wikipedia

Synonyms

(+)-Dihydromyricetin; Ampelopsin

 

Structure image - Dihydromyricetin

C1=C(C=C(C(=C1O)O)O)[C@@H]2[C@H](C(=O)C3=C(C=C(C=C3O2)O)O)O

Supporting references

Link Tested on Impact factor Notes Publication date
Scutellaria baicalensis extract and baicalein inhibit replication of SARS-CoV-2 and its 3C-like protease in vitro
Small molecule Enzyme assay In vitro In silico 		in silico; in vitro enzyme assay; Vero cells; HEK293T cell lysates; SARS-CoV-2 isolate C-Tan-nCoV Wuhan strain 01 4.31

Inhibits SARS-CoV-2 3C-like protease in vitro with IC50 of 1.2 µM.

 Jan/04/2021

AI-suggested references

Link Publication date
Social isolation induces neuroinflammation and microglia overactivation, while dihydromyricetin prevents and improves them.
Jan/13/2022
Modelling studies reveal the importance of the C-terminal inter motif loop of NSP1 as a promising target site for drug discovery and screening of potential phytochemicals to combat SARS-CoV-2.
Apr/19/2021
Effect of dihydromyricetin on SARS-CoV-2 viral replication and pulmonary inflammation and fibrosis.
Aug/08/2021
Flavonols and dihydroflavonols inhibit the main protease activity of SARS-CoV-2 and the replication of human coronavirus 229E.
Apr/12/2022
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