dbq33b4p7

A heterocyclic alkaloid.

Phase of research

Potential treatment - pre-clinical evidence

How it helps

Antiviral

Drug status

Experimental

1
Supporting references
0
Contradictory references
0
AI-suggested references
0
Clinical trials

General information

dbq33b4p7 is a tylophorine derivative with in vitro anti-SARS-CoV-2 activity (Yang et al., 2020).

 

Structure image - dbq33b4p7

CCN1CC2=C(C(O)C1C)C1=CC=C(OC)C=C1C1=CC(OC)=C(OC)C=C21


Supporting references

Link Tested on Impact factor Notes Publication date
Inhibition of SARS-CoV-2 by Highly Potent Broad-Spectrum Anti-Coronaviral Tylophorine-Based Derivatives
Small molecule In vitro
Vero E6 cells 4.23

Manifested in vitro anti-SARS-CoV-2 activity in Vero E6 cells with EC50 of20 nM in a cytopathic effect assay and 31.9 nM in an immunofluorescence assay, with a selectivity index of 125 or 93.

Dec/14/2020