Other substances

Curcumin

A plant phenolic pigment.

Phase of research

Potential treatment - theoretical effect

How it helps

Antiviral

Drug status

Natural product

Supporting references

Contradictory references

AI-suggested references

Clinical trials

General information

Curcumin is a bioactive plant polyphenol pigment. It blocks the formation of reactive-oxygen species and has anti-inflammatory properties due to its inhibitory activities targeted against several enzymes involved in inflammation. Curcumin was also shown to have antineoplastic, antibacterial, hypoglycaemic, or wound-healing properties. It is clinically trialled for various health conditions (DrugBank, NCIt).

Curcumin on PubChem
Curcumin on Wikipedia

Synonyms

Diferuloylmethane; Natural Yellow 3; Turmeric Yellow

COC1=C(C=CC(=C1)/C=C/C(=O)CC(=O)/C=C/C2=CC(=C(C=C2)O)OC)O

Supporting references

Link	Tested on	Impact factor	Notes	Publication date
Pharmacoinformatics and hypothetical studies on allicin, curcumin, and gingerol as potential candidates against COVID-19-associated proteases 3CLpro Cathepsin K Small molecule In silico	in silico	3.22	Suggested to inhibit the host's cathepsin K and the SARS-CoV-2 3C-like protease.	Sep/02/2020
Catechin and curcumin interact with S protein of SARS-CoV2 and ACE2 of human cell membrane: insights from computational studies Spike protein ACE2 Small molecule In silico	in silico	4.00	Predicted to bind SARS-CoV-2 Spike protein, the host's ACE2 receptor or their complex (Spike's RBD/ACE2).	Jan/21/2021
Virtual screening and molecular dynamics simulation study of plant-derived compounds to identify potential inhibitors of main protease from SARS-CoV-2 3CLpro Small molecule In silico	in silico	8.99	Predicted to inhibit the SARS-CoV-2 3C-like protease.	Feb/01/2021
Repurposing potential of Ayurvedic medicinal plants derived active principles against SARS-CoV-2 associated target proteins revealed by molecular docking, molecular dynamics and MM-PBSA studies Spike protein 3CLpro RdRpol ACE2 Small molecule In silico	in silico	4.55	Predicted to interact with host's ACE2 receptor and furin.	Feb/03/2021
In silico Screening of Natural Compounds as Potential Inhibitors of SARS-CoV-2 Main Protease and Spike RBD: Targets for COVID-19 Spike protein 3CLpro Small molecule In silico	in silico	4.19	Predicted to inhibit SARS-CoV-2 3C-like protease (covalently) and Spike protein RBD.	Jan/19/2021
Virtual screening of curcumin and its analogs against the spike surface glycoprotein of SARS-CoV-2 and SARS-CoV Spike protein Small molecule In silico	in silico	3.22	Predicted to inhibit SARS-CoV-2 Spike protein.	Jan/05/2021
Oral nano‐curcumin formulation efficacy in management of mild to moderate hospitalized coronavirus disease‐19 patients: An open label nonrandomized clinical trial Small molecule Non-randomized controlled open trial Moderate severity Mild severity Mixed substance	Patients	4.09	Faster clinical improvement was observed in the treatment group. Sample size: 20 + 20 control. Dosage: 80 mg twice a day - "Sinacurcumin® soft gel" formulation containing "curcuminoids as nanomicelle".	Jan/03/2021

AI-suggested references

Link	Publication date
Oral nano-curcumin formulation efficacy in management of mild to moderate hospitalized coronavirus disease-19 patients: An open label nonrandomized clinical trial.	Jan/03/2021
Immunomodulatory and anti-cytokine therapeutic potential of curcumin and its derivatives for treating COVID-19 - a computational modeling.	Jun/15/2020
Newly Developed Highly Bioavailable Curcumin Formulation, curcuRougeTM, Reduces Neutrophil/Lymphocyte Ratio in the Elderly: A Double-Blind, Placebo-Controlled Clinical Trial.	Mar/09/2021
Natural Agents Modulating ACE-2: A Review of Compounds with Potential against SARS-CoV-2 Infections.	Jan/19/2021
Effect of nanocurcumin supplementation on the severity of symptoms and length of hospital stay in patients with COVID-19: A randomized double-blind placebo-controlled trial.	Jan/12/2022
Biochemical study on the protective effect of curcumin on acetaminophen and gamma-irradiation induced hepatic toxicity in rats.	Jul/15/2021
Mechanistic Aspects of Medicinal Plants and Secondary Metabolites against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2).	Jul/07/2021
Pomegranate peel polyphenols prophylaxis against SARS-CoV-2 main protease by in-silico docking and molecular dynamics study.	Sep/27/2021
Effect of ArtemiC in patients with COVID-19: A Phase II prospective study.	May/21/2020
Virtual screening for functional foods against the main protease of SARS-CoV-2.	Dec/16/2021
Curcumin and Piperine in COVID-19: A Promising Duo to the Rescue?	Mar/15/2022
Nature-derived hit, lead, and drug-like small molecules: Current status and future aspects against key target proteins of Coronaviruses.	Jul/08/2021
Antiinflammatory potential of nano-curcumin as an alternative therapeutic agent for the treatment of mild-to-moderate hospitalized COVID-19 patients in a placebo-controlled clinical trial.	Jan/17/2022
Immunomodulatory effects of nanocurcumin on Th17 cell responses in mild and severe COVID-19 patients.	Dec/28/2020
A Review of Medicinal Plants with Antiviral Activity Available in Bangladesh and Mechanistic Insight Into Their Bioactive Metabolites on SARS-CoV-2, HIV and HBV.	Nov/08/2021
Robust antimicrobial photodynamic therapy with curcumin-poly (lactic-co-glycolic acid) nanoparticles against COVID-19: A preliminary in vitro study in Vero cell line as a model.	Apr/07/2021
Curcumin inhibits spike protein of new SARS-CoV-2 variant of concern (VOC) Omicron, an in silico study	Dec/22/2020
Anti-Viral Potential and Modulation of Nrf2 by Curcumin: Pharmacological Implications	Jul/29/2021
Pulsed blue light, saliva and curcumin significantly inactivate human coronavirus.	Dec/28/2021
Potential effects of curcumin in the treatment of COVID-19 infection	Sep/16/2021
Therapeutic Approach against 2019-nCoV by Inhibition of ACE-2 Receptor	Nov/12/2020
In silico analysis of phytochemicals as potential inhibitors of proteases involved in SARS-CoV-2 infection	Dec/29/2020
Molecular docking and dynamics studies of curcumin with COVID-19 proteins.	Jun/10/2021
Turmeric Root and Its Bioactive Ingredient Curcumin Effectively Neutralize SARS-CoV-2 In Vitro	Sep/23/2021
Curcumin (a constituent of turmeric): New treatment option against COVID-19.	Sep/06/2020
Structural Variability, Expression Profile, and Pharmacogenetic Properties of TMPRSS2 Gene as a Potential Target for COVID-19 Therapy	Feb/16/2021
Bioactive Polyphenolic Compounds Showing Strong Antiviral Activities against Severe Acute Respiratory Syndrome Coronavirus 2.	Jun/15/2021
The impact of curcumin derived polyphenols on the structure and flexibility COVID-19 main protease binding pocket: a molecular dynamics simulation study.	Jul/19/2021
Molecular Docking and Molecular Dynamics Simulations Discover Curcumin Analogue as a Plausible Dual Inhibitor for SARS-CoV-2	Feb/04/2022
A computational approach for the screening of potential antiviral compounds against SARS-CoV-2 protease: Ionic liquid vs herbal and natural compounds.	Jan/07/2021
Curcumin as a Potential Treatment for COVID-19.	May/07/2021
Phytochemical Moieties From Indian Traditional Medicine for Targeting Dual Hotspots on SARS-CoV-2 Spike Protein: An Integrative in-silico Approach.	May/07/2021
Multi-omics-based identification of SARS-CoV-2 infection biology and candidate drugs against COVID-19.	Oct/10/2020
Nano-curcumin therapy, a promising method in modulating inflammatory cytokines in COVID-19 patients.	Oct/20/2020
Molecular dynamic simulations reveal anti-SARS-CoV-2 activity of mitocurcumin by potentially blocking innate immune evasion proteins NSP3 and NSP16	May/10/2022
Enhanced curcumin loaded nanocellulose: a possible inhalable nanotherapeutic to treat COVID-19.	Jan/04/2022
In silico targeting SARS-CoV-2 spike protein and main protease by biochemical compounds	Sep/22/2021
Silymarin/curcumin loaded albumin nanoparticles coated by chitosan as muco-inhalable delivery system observing anti-inflammatory and anti COVID-19 characterizations in oleic acid triggered lung injury and in vitro COVID-19 experiment	Dec/28/2021
Curcumin Inhibits In Vitro SARS-CoV-2 Infection In Vero E6 Cells through Multiple Antiviral Mechanisms	Nov/16/2021
Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets	Aug/25/2020
In silico study of some selective phytochemicals against a hypothetical SARS-CoV-2 spike RBD using molecular docking tools.	Aug/28/2021
Antiviral and immunomodulatory activity of curcumin: A case for prophylactic therapy for COVID-19	Oct/18/2021
Docking Analysis of Some Bioactive Compounds from Traditional Plants against SARS-CoV-2 Target Proteins	Apr/20/2022
The combination of bromelain and curcumin as an immune-boosting nutraceutical in the prevention of severe COVID-19	Oct/19/2021
Ligand-based quantitative structural assessments of SARS-CoV-2 3CLpro inhibitors: An analysis in light of structure-based multi-molecular modeling evidences	Aug/11/2020
Design and various in silico studies of the novel curcumin derivatives as potential candidates against COVID-19 -associated main enzymes	Oct/18/2021
Potential In Vitro Inhibition of Selected Plant Extracts against SARS-CoV-2 Chymotripsin-Like Protease (3CLPro) Activity	Jun/29/2021
Oral Curcumin With Piperine as Adjuvant Therapy for the Treatment of COVID-19: A Randomized Clinical Trial.	May/28/2021
Activity of phytochemical constituents of Curcuma longa (turmeric) and Andrographis paniculata against coronavirus (COVID-19): an in silico approach.	Oct/16/2020
In silico drug discovery of major metabolites from spices as SARS-CoV-2 main protease inhibitors.	Oct/08/2020
Molecular Docking Studies to Identify Promising Natural Inhibitors Targeting SARS-CoV-2 Nsp10-Nsp16 Protein Complex	Feb/28/2022
Synthesis of aspirin-curcumin mimic conjugates of potential antitumor and anti-SARS-CoV-2 properties.	Nov/04/2021
Plant Products as Inhibitors of Coronavirus 3CL Protease.	Mar/09/2021
Nanocurcumin Potently Inhibits SARS-CoV-2 Spike Protein-Induced Cytokine Storm by Deactivation of MAPK/NF-kappaB Signaling in Epithelial Cells	Nov/27/2021
Reducing SARS-CoV-2 pathological protein activity with small molecules.	Apr/05/2021
The Inhibitory Effect of Curcumin on Virus-Induced Cytokine Storm and Its Potential Use in the Associated Severe Pneumonia	Feb/01/2021
Potential use of Turmeric in COVID-19	Apr/14/2021
Preclinical Efficacy and Safety Studies of Formulation SSV-003, a Potent Anti-Viral Herbal Formulation	Dec/30/2020
Inhibitory effects of specific combination of natural compounds against SARS-CoV-2 and its Alpha, Beta, Gamma, Delta, Kappa, and Mu variants	Jan/21/2022
Oral nano-curcumin formulation efficacy in the management of mild to moderate outpatient COVID-19: A randomized triple-blind placebo-controlled clinical trial.	Jun/19/2021
Molecular docking analysis of Withaferin A from Withania somnifera with the Glucose regulated protein 78 (GRP78) receptor and the SARS-CoV-2 main protease.	Apr/30/2020
Novel cyclohexanone compound as a potential ligand against SARS-CoV-2 main-protease.	Oct/01/2020
Structure-based drug designing for potential antiviral activity of selected natural products from Ayurveda against SARS-CoV-2 spike glycoprotein and its cellular receptor	May/24/2020
Curcumin, a traditional spice component, can hold the promise against COVID-19?	Sep/12/2020
Evaluation of potency of the selected bioactive molecules from Indian medicinal plants with MPro of SARS-CoV-2 through in silico analysis.	May/21/2021
Selective targeting of the inactive state of hematopoietic cell kinase (Hck) with a stable curcumin derivative	Apr/23/2021
Natural Products, Alone or in Combination with FDA-Approved Drugs, to Treat COVID-19 and Lung Cancer.	Jun/18/2021
A Novel Combination of Vitamin C, Curcumin and Glycyrrhizic Acid Potentially Regulates Immune and Inflammatory Response Associated with Coronavirus Infections: A Perspective from System Biology Analysis	Mar/03/2022
Addressing the potential role of curcumin in the prevention of COVID-19 by targeting the Nsp9 replicase protein through molecular docking	Oct/09/2020
Potential of turmeric-derived compounds against RNA-dependent RNA polymerase of SARS-CoV-2: An in-silico approach	Apr/06/2021
Phenolic compounds disrupt spike-mediated receptor-binding and entry of SARS-CoV-2 pseudo-virions	Jun/17/2021
A triple-blind, placebo-controlled, randomized clinical trial to evaluate the effect of curcumin-containing nanomicelles on cellular immune responses subtypes and clinical outcome in COVID-19 patients	Sep/19/2021
Scrutinizing the Feasibility of Nonionic Surfactants to Form Isotropic Bicelles of Curcumin: a Potential Antiviral Candidate Against COVID-19	Dec/29/2021

Clinical trials

ID	Title	Status	Phase	Start date	Completion date
NCT05130671	Nutritional Supplementation of Flavonoids Quercetin and Curcumin for Early Mild Symptoms of COVID-19	Completed	Not Applicable	Oct/25/2021	Dec/31/2021
Alternative id - 785/RC/KEMU/25.10.2021 Interventions - Drug: Standard of care\|Dietary Supplement: Investigational treatment Study type - Interventional Study results - No Results Available Locations - King Edward Medical University Teaching Hospital, Lahore, Punjab, Pakistan Study designs - Allocation: Randomized\|Intervention Model: Parallel Assignment\|Masking: None (Open Label)\|Primary Purpose: Treatment Enrollment - 50 Age - 18 Years and older (Adult, Older Adult) Outcome measures - Testing negative for SARS-CoV-2 by Reverse Transcription Polymerase Chain Reaction (RT-PCR)\|COVID-19 symptoms improvement\|Improvement in CRP level\|Improvement in D-dimers level\|Improvement in LDH levels\|Improvement in ferritin levels\|Improvement in full blood count (CBC)
NCT05008003	Study to Investigate Treatment Benefits of Combination of Vit D3, Quercetin and Curcumin for Early Mild Symptoms of COVID-19	Recruiting	Not Applicable	Aug/06/2021	Mar/31/2022
Alternative id - CQC/COVID/08-2021 Interventions - Drug: Standard of care\|Dietary Supplement: Combination of oral quercetin, curcumin and vitamin D3 Study type - Interventional Study results - No Results Available Locations - Ayub Teaching Hospital, Abbottabad, Khyber Pakhtunkhwa, Pakistan Study designs - Allocation: Randomized\|Intervention Model: Parallel Assignment\|Masking: None (Open Label)\|Primary Purpose: Treatment Enrollment - 50 Age - 18 Years and older (Adult, Older Adult) Outcome measures - SARS-CoV-2 Negativity by RT-PCR\|COVID-19 symptoms improvement\|Changes in CRP level\|Changes in D-dimer level\|Changes in LDH level\|Changes in ferritin level\|Changes in full blood count
NCT05150782	The Effect of Micellized Food Supplements on Health-related Quality of Life in Patients With Post-acute COVID-19 Syndrome.	Not yet recruiting	Not Applicable	Jan/17/2022	Oct/10/2022
Alternative id - MyCellVSLongCOVID Interventions - Dietary Supplement: Curcumin/Boswellia Serrata/Ascorbic acid mixture Study type - Interventional Study results - No Results Available Locations - Study designs - Allocation: N/A\|Intervention Model: Single Group Assignment\|Masking: None (Open Label)\|Primary Purpose: Treatment Enrollment - 32 Age - 18 Years to 85 Years (Adult, Older Adult) Outcome measures - Change in health-related quality of life\|Change in patient selected functional limitations in daily life, measured with the 'Patient specific functional scale (PSFS).\|Change in general health status\|Change in general health\|Change in Post COVID functional status measured with the 'Post COVID Functional Status' (PCFS).

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