Other substances

CoV2-12

An anti-Spike (SARS-CoV-2) human monoclonal antibody.

Phase of research

Potential treatment - pre-clinical evidence

How it helps

Antiviral

Drug status

Experimental

1
 Supporting references
0
 Contradictory references
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 AI-suggested references
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 Clinical trials

General information

CoV2-12 is a human monoclonal antibody targeting Spike protein RBD (SARS-CoV-2). It was identified using single-chain variable fragment phage display technique. Its epitope partially overlaps with the CR3022's one and is completely conserved between SARS-CoV and SARS-CoV-2. It neutralized SARS-CoV-2 in vitro with NT50 of 18.17 μg/ml (Ku et al., 2021).

 

Supporting references

Link Tested on Impact factor Notes Publication date
Molecular determinants and mechanism for antibody cocktail preventing SARS-CoV-2 escape
Spike protein Biophysical assay Animal model In vitro Antibody 		in vitro binding assay; in vitro biophysical assay; Vero cells; Vero E6 cells; TMPRSS2-expressing Vero E6 cells; BALB/c mice; SARS-CoV-2 S pseudovirus; SARS-CoV-2 mouse-adapted strain CMA-3; SARS-CoV-2 clinical isolate USA/WA1/2020 12.12

Binds to RBD of SARS-CoV-2 Spike protein and neutralizes SARS-CoV-2 live virus in vitro with NT50 of 18.17 μg/ml.

 Jan/20/2021
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