Other substances

Coronil

A herbal medicine.

Phase of research

Potential treatment - pre-clinical evidence

How it helps

Other treatment

Drug status

Natural product

1
 Supporting references
0
 Contradictory references
2
 AI-suggested references
0
 Clinical trials

General information

Coronil is a herbal medicine made of extracts from Withania somnifera, Tinospora cordifolia, and Ocimum sanctum, which contains various phytochemicals (ursolic acid, betulinic acid, withanone, withaferine A, withanoside IV, withanoside V, cordifolioside A, magnoflorine, rosmarinic acid, and palmatine (Balkrishna et al., 2020).

 

Supporting references

Link Tested on Impact factor Notes Publication date
Application of Humanized Zebrafish Model in the Suppression of SARS-CoV-2 Spike Protein Induced Pathology by Tri-Herbal Medicine Coronil via Cytokine Modulation
Spike protein Animal model Mixed substance 		Zebrafish xeno-transplanted with A549 human lung epithelial cells 3.27

Coronil reduced SARS-CoV-2 spike protein-induced mortality, inflammatory response and tissue damage in a humanized zebrafish model.

 Nov/02/2020

AI-suggested references

Link Publication date
28-day repeated dose toxicological evaluation of Coronil in Sprague Dawley rats: Behavioral, hematological, biochemical and histopathological assessments under GLP compliance.
Jul/30/2020
Coronil, a Tri-Herbal Formulation, Attenuates Spike-Protein-Mediated SARS-CoV-2 Viral Entry into Human Alveolar Epithelial Cells and Pro-Inflammatory Cytokines Production by Inhibiting Spike Protein-ACE-2 Interaction.
Mar/16/2021
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