Other substances

Clomiphene

An ovulatory stimulant.

Phase of research

Potential treatment - pre-clinical evidence

How it helps

Antiviral

Drug status

Used to treat other disease

1
 Supporting references
0
 Contradictory references
0
 AI-suggested references
0
 Clinical trials

General information

Clomiphene is a nonsteroidal ovulatory stimulant. It induces follicle stimulating hormone and luteinizing hormone secretion. It acts via oestrogen receptor binding and displays both estrogenic and anti-estrogenic activities. Clomiphene has been studied for its potential in breast cancer treatment (NCIt).

Clomiphene on DrugBank
Clomiphene on PubChem
Clomiphene on Wikipedia

Marketed as

ANDROXAL; CLOMIFERT; CLOSTILBEGYT; CLOMID; OMIFIN; SEROPHENE

 

Structure image - Clomiphene

CCN(CC)CCOC1=CC=C(C=C1)C(=C(C2=CC=CC=C2)Cl)C3=CC=CC=C3

Supporting references

Link Tested on Impact factor Notes Publication date
Several FDA-Approved Drugs Effectively Inhibit SARS-CoV-2 Infection in vitro
Small molecule In vitro Screening 		BHK21-hACE2 cells; SARS-CoV-2 Spike Δ18-pseudotyped virus; SARS-CoV-2 strain BetaCoV/Shenzhen/SZTH-003/2020 4.23

The drug (citrate) inhibited SARS-CoV-2 pseudovirus and live virus in vitro with IC50s of 3.32 μM (2.94 μM and 9.53 μM in different experiments) and 9.73 μM, respectively. When combined with vortioxetine and asenapine (hydrochloride), the observed IC50s for pre-treatment and co-treatment were 0.34 μM and 1.93 μM with SIs of ca. 43 and 8.3, respectively.

 Feb/05/2021
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