Other substances

Clemastine

A first generation antihistamine.

Phase of research

Potential treatment - pre-clinical evidence

How it helps

Antiviral

Drug status

Used to treat other disease

1
 Supporting references
0
 Contradictory references
1
 AI-suggested references
0
 Clinical trials

General information

Clemastine is a first generation antihistamine, which acts as a H1-receptor antagonist and a muscarinic antagonist (ChEBI).

Clemastine on DrugBank
Clemastine on PubChem
Clemastine on Wikipedia

Marketed as

AGASTEN; ALLERHIST-1; CLEMASTINE FUMARATE; TAVEGIL; TAVEGYL; TAVIST; TAVIST-1

 

Structure image - Clemastine

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Supporting references

Link Tested on Impact factor Notes Publication date
Identification of SARS-CoV-2 entry inhibitors among already approved drugs
Small molecule In vitro Screening 		Huh-7 cells (pseudovirus-based assay); Vero E6 cells (antiviral activity); SARS-CoV-2 (WIV04) 5.06

Inhibits SARS-CoV-2 spike protein pseudovirus cell entry and significally inhibits viral replication in vitro. Has the lowest EC50 value of the drugs tested in this study.

 Oct/28/2020

AI-suggested references

Link Publication date
On-target versus off-target effects of drugs inhibiting the replication of SARS-CoV-2.
Aug/19/2020
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