Other substances

Cleistanthin B

A lignan.

Phase of research

Potential treatment - pre-clinical evidence

How it helps

Antiviral

Drug status

Natural product

1
 Supporting references
0
 Contradictory references
0
 AI-suggested references
0
 Clinical trials

General information

Cleistanthin B is a natural antihypertensive agent (ChEBI).

Cleistanthin B on PubChem

Synonyms

Diphyllin-4-β-D-glucopyranoside

 

Structure image - Cleistanthin B

COC1=C(C=C2C(=C1)C(=C3C(=C2O[C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)CO)O)O)O)COC3=O)C5=CC6=C(C=C5)OCO6)OC

Supporting references

Link Tested on Impact factor Notes Publication date
Antiviral Activity of Vacuolar ATPase Blocker Diphyllin against SARS-CoV-2
Small molecule In vitro 		Vero cells; Vero E6 cells; Caco-2 cells; SARS-CoV-2 strain SARS-CoV-2/human/Czech Republic/951/2020 4.15

Reduced SARS-CoV-2 plaque counts in Vero cells with an EC50 of ca. 6.51 μM and an SI of >15.36. The compound's solubility in water is low, however.

 Feb/25/2021
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