Ciluprevir
A hepatitis C virus protease inhibitor.
General information
Ciluprevir is a peptidomimetic hepatitis C virus NS3-4A serine protease inhibitor (NCIt).
Ciluprevir on DrugBank
Ciluprevir on PubChem
Ciluprevir on Wikipedia
Synonyms
BILN 2061
CC(C)NC1=NC(=CS1)C2=NC3=C(C=CC(=C3)OC)C(=C2)O[C@@H]4C[C@H]5C(=O)N[C@@]6(C[C@H]6/C=C\CCCCC[C@@H](C(=O)N5C4)NC(=O)OC7CCCC7)C(=O)O
Supporting references
| Link | Tested on | Impact factor | Notes | Publication date |
|---|---|---|---|---|
|
A drug repurposing screen identifies hepatitis C antivirals as inhibitors of the SARS-CoV2 main protease
3CLpro Enzyme assay In vitro In silico Screening |
in silico; in vitro enzyme assay | 2.74 | Inhibited the SARS-CoV-2 3C-like protease in vitro with IC50 of ca. 20.77 μM. |
Feb/01/2021 |
