Chloroxine
A quinoline antimicrobial.
General information
Chloroxine is a synthetic quinoline antimicrobial. It is used for the treatment of dandruff and seborrheic dermatitis (ChEBI).
Chloroxine on DrugBank
Chloroxine on PubChem
Chloroxine on Wikipedia
Synonyms
Kloroxin; Dichlorchinolinol; 5,7-Dichloro-8-hydroxyquinoline
Marketed as
CAPITROL; ENDIARON
C1=CC2=C(C(=C(C=C2Cl)Cl)O)N=C1
Supporting references
| Link | Tested on | Impact factor | Notes | Publication date |
|---|---|---|---|---|
|
Discovery of Clioquinol and analogues as novel inhibitors of Severe Acute Respiratory Syndrome Coronavirus 2 infection, ACE2 and ACE2 - Spike protein interaction in vitro
Spike protein ACE2 Enzyme assay In vitro |
in vitro binding assay; in vitro enzyme assay; Vero E6 cells; SARS-CoV-2 strain USA_WA1/2020 | The compound inhibited SARS-CoV-2-induced cytopathic effect in Vero E6 cells with an IC50 of 16.30 μM. It was shown to block the interaction between Spike protein RBD and a recombinant form of human ACE2 receptor. It also impeded ACE2’s exopeptidase activity in vitro. |
Mar/11/2021 |
AI-suggested references
| Link | Publication date |
|---|---|
|
Repurposing clinically approved drugs for COVID-19 treatment targeting SARS-CoV-2 papain-like protease.
|
Aug/06/2021 |
