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NCT04757818
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Double-blind, Randomized, Parallel, Placebo-controlled Clinical Study to Evaluate the Viral Load of SARS-CoV-2 (COVID-19) in the Oral Cavity of SARS-CoV-2 Positive Subjects After the Use of a Mouthwash Containing Cetylpyridinium Chloride 0,07%. |
Completed |
Not Applicable |
Feb/17/2021 |
Jun/03/2021 |
- Alternative id - CPC COVID
- Interventions - Other: 0.07% cetylpyridinium chloride (CPC) in mouthwash|Other: Distilled water with the same colorant as the experimental product
- Study type - Interventional
- Study results - No Results Available
- Locations - CAP Gorg, Badalona, Barcelona, Spain|CAP Gran Sol, Badalona, Barcelona, Spain|CAP St Roc, Badalona, Barcelona, Spain|CAP Barri Llatí, Santa Coloma De Gramenet, Barcelona, Spain|CAP Fondo, Santa Coloma De Gramenet, Barcelona, Spain|CAP Santa Rosa, Santa Coloma De Gramenet, Barcelona, Spain|CAP Singuerlin, Santa Coloma De Gramenet, Barcelona, Spain|CAP Dr Robert, Badalona, Spain|CAP Les Franqueses del Vallès, Bellavista, Spain|CAP Canovelles/Granollers Oest, Canovelles, Spain|CAP Granollers Centre, Granollers, Spain|ABS Gatassa, Mataró, Spain|EAP Mollet Est, Mollet Del Vallès, Spain|CAP Montornés/Montmeló, Montornés del Vallès, Spain|CAP Palau, Palau-solità i Plegamans, Spain|EAP Parets del Vallès, Parets del Vallès, Spain|CAP Sant Celoni, Sant Celoni, Spain|CAP Santa Perpètua, Santa Perpètua de Mogoda, Spain|EAP Vilassar de Mar, Vilassar de Mar, Spain
- Study designs - Allocation: Randomized|Intervention Model: Parallel Assignment|Masking: Double (Participant, Investigator)|Primary Purpose: Other
- Enrollment - 118
- Age - 18 Years and older (Adult, Older Adult)
- Outcome measures - SARS-CoV-2 viral load in saliva samples measured by RT-qPCR|Nucleocapsid protein levels in saliva samples measured by ELISA|SARS-CoV-2 viral load in saliva samples determined by RT-qPCR|Sensitivity and specificity of different rapid SARS-CoV-2 antigen tests compared to RT-qPCR in saliva samples|Intraindividual difference in SARS-CoV-2 infectivity in vitro before and after treatment with a 0.07% CPC or placebo
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NCT04723446
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Efficacy of Mouthwashes in Reducing Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Viral Load in the Saliva |
Completed |
Not Applicable |
May/19/2021 |
Oct/25/2021 |
- Alternative id - TBC
- Interventions - Drug: Corsodyl® Alcohol free -0.2 % Chlorhexidine digluconate|Drug: Colgate Peroxyl® -1.5% Hydrogen peroxide|Other: Oral-B® Gum & Enamel Care -Cetylpyridinium chloride|Other: No rinsing
- Study type - Interventional
- Study results - No Results Available
- Locations - Newham Hospital, London, United Kingdom|Royal London Hospital, London, United Kingdom
- Study designs - Allocation: Randomized|Intervention Model: Parallel Assignment|Masking: Single (Investigator)|Primary Purpose: Other
- Enrollment - 54
- Age - 18 Years and older (Adult, Older Adult)
- Outcome measures - Viral load changes in the saliva within groups|Difference in the viral load changes in the saliva between groups
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NCT04820803
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Assessment of the Impact of Oral Intervention With Cetylpyridinium Chloride to Decrease SARS-CoV-2 Viral Load in Patients With COVID-19 |
Completed |
Not Applicable |
Feb/03/2021 |
Jun/30/2021 |
- Alternative id - CPC01
- Interventions - Other: ORAL INTERVENTION WITH CETYLPYRIDINIUM CHLORIDE|Other: PLACEBO
- Study type - Interventional
- Study results - No Results Available
- Locations - Seminario Health Center and Lozano Blesa University Clinical Hospital, Zaragoza, Spain
- Study designs - Allocation: Randomized|Intervention Model: Parallel Assignment|Masking: Double (Participant, Investigator)|Primary Purpose: Prevention
- Enrollment - 80
- Age - 18 Years to 80 Years (Adult, Older Adult)
- Outcome measures - Threshold cycle value of SARS-CoV-2 by Polymerase Chain Reaction (PCR) in saliva samples|SARS-CoV-2 Nucleocapsid protein in saliva by ELISA
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NCT05178173
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Efficacy of Oral Rinses for Inactivation of COVID-19 (MOR2) |
Recruiting |
Not Applicable |
Jan/20/2022 |
Jan/01/2023 |
- Alternative id - 21-3019
- Interventions - Other: Placebo Comparator: Sterile Water|Other: 27% Ethanol plus essential oils|Other: 0.075% Cetylpyridinium Chloride
- Study type - Interventional
- Study results - No Results Available
- Locations - General and Oral Health Center, Chapel Hill, North Carolina, United States
- Study designs - Allocation: Randomized|Intervention Model: Parallel Assignment|Masking: Triple (Participant, Care Provider, Outcomes Assessor)|Primary Purpose: Treatment
- Enrollment - 150
- Age - 18 Years to 65 Years (Adult, Older Adult)
- Outcome measures - Change in Quantitative Polymerase Chain Reaction (qPCR) from Baseline to 15 Minutes|Change in Quantitative Polymerase Chain Reaction (qPCR) from Baseline to 30 Minutes
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NCT04721457
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The Efficacy of Pre-procedural Mouth Rinses on COVID-19 Saliva Viral Load |
Completed |
Phase 4 |
Jan/03/2021 |
Dec/10/2021 |
- Alternative id - 1384
- Interventions - Drug: Distilled Water|Drug: 1% Povidone Iodine (PVP-I)|Drug: 1.5% Hydrogen Peroxide (H2O2)|Drug: 0.075% Cetylpyridinium Chloride (CPC)|Drug: 0.1% Sodium Hypochlorite
- Study type - Interventional
- Study results - No Results Available
- Locations - Alhamra TETAMMAN clinic (PHC), Jeddah, Saudi Arabia
- Study designs - Allocation: Randomized|Intervention Model: Parallel Assignment|Masking: Triple (Participant, Investigator, Outcomes Assessor)|Primary Purpose: Prevention
- Enrollment - 120
- Age - 18 Years and older (Adult, Older Adult)
- Outcome measures - Change in SARS-Cov-2 viral load (Quantitative Real-Time Reverse-Transcriptase Polymerase Chain Reaction (qRT-PCR))|ct values
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NCT04584684
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Mouth Rinses for Inactivation of COVID-19 |
Active, not recruiting |
Phase 2 |
Dec/18/2020 |
Jun/01/2022 |
- Alternative id - 20-2040
- Interventions - Other: Saline|Drug: 1.5% w/v Hydrogen Peroxide|Drug: 0.12% Chlorohexidine Gluconate|Drug: 27% Ethanol plus essential oils|Drug: 0.5% w/v Povidone-iodide|Drug: 0.075% Cetylpyridinium Chloride
- Study type - Interventional
- Study results - No Results Available
- Locations - General and Oral Health Center, Chapel Hill, North Carolina, United States
- Study designs - Allocation: Randomized|Intervention Model: Parallel Assignment|Masking: Triple (Participant, Care Provider, Outcomes Assessor)|Primary Purpose: Treatment
- Enrollment - 129
- Age - 18 Years to 65 Years (Adult, Older Adult)
- Outcome measures - Change in Quantitative Polymerase Chain Reaction (qPCR) from Baseline to 30 Minutes
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