Other substances

Ceftriaxone

A cephalosporin antibiotic.

Phase of research

Potential treatment - clinical evidence

How it helps

Other treatment

Drug status

Used to treat other disease

Supporting references

Contradictory references

AI-suggested references

Clinical trials

General information

Ceftriaxone is a third-generation cephalosporin antibiotic. It targets gram-negative bacterial cell wall synthesis. Ceftriaxone crosses the blood-brain barrier (NCIt).

Ceftriaxone on DrugBank
Ceftriaxone on PubChem
Ceftriaxone on Wikipedia

Marketed as

ACANTEX; BIOTRAKSON; CEFTRIAXONE; ROCEPHINE

CN1C(=NC(=O)C(=O)N1)SCC2=C(N3[C@@H]([C@@H](C3=O)NC(=O)/C(=N\OC)/C4=CSC(=N4)N)SC2)C(=O)O

Supporting references

Link	Tested on	Impact factor	Notes	Publication date
Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China.	Patients		24.6 % of patients received this therapy	Feb/07/2020
The study of antiviral drugs targeting SARS-CoV-2 nucleocapsid and spike proteins through large-scale compound repurposing Nucleocapsid protein Small molecule In silico	in silico		Predicted to bind SARS-CoV-2 Nucleocapsid protein.	Mar/01/2021

AI-suggested references

Link	Publication date
Eculizumab treatment in patients with COVID-19: preliminary results from real life ASL Napoli 2 Nord experience.	Jun/04/2020
Long-term application of hydroxychloroquine could not prevent the infection of COVID-19.	Mar/02/2021
Polymyxin B haemoperfusion treatment for respiratory failure and hyperferritinaemia due to COVID-19.	Nov/01/2020
Ceftriaxone Mediated Synthesized Gold Nanoparticles: A Nano-Therapeutic Tool to Target Bacterial Resistance	Nov/08/2021
In Silico Screening of Bioactive Compounds of Representative Seaweeds to Inhibit SARS-CoV-2 ACE2-Bound Omicron B.1.1.529 Spike Protein Trimer	Mar/25/2021
Use of repurposed and adjuvant drugs in hospital patients with covid-19: multinational network cohort study.	May/11/2021

Clinical trials

ID	Title	Status	Phase	Start date	Completion date
NCT02735707	Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community- Acquired Pneumonia	Recruiting	Phase 3	Apr/11/2016	Dec/01/2025
Alternative id - U1111-1189-1653\|2015-002340-14\|602525\|16/631\|APP1101719\|158584 Interventions - Drug: Ceftriaxone\|Drug: Moxifloxacin or Levofloxacin\|Drug: Piperacillin-tazobactam\|Drug: Ceftaroline\|Drug: Amoxicillin-clavulanate\|Drug: Standard course macrolide\|Drug: Extended course macrolide\|Other: No systemic corticosteroid\|Drug: Fixed-duration Hydrocortisone\|Drug: Shock-dependent hydrocortisone\|Drug: Fixed-duration higher dose Hydrocortisone\|Other: No antiviral agent for influenza\|Drug: Five-days oseltamivir\|Drug: Ten-days oseltamivir\|Other: No antiviral agent for COVID-19\|Drug: Lopinavir / Ritonavir\|Drug: Hydroxychloroquine\|Drug: Hydroxychloroquine + lopinavir/ritonavir\|Drug: Ivermectin\|Other: No immune modulation for COVID-19\|Drug: Interferon beta-1a\|Drug: Anakinra\|Drug: Tocilizumab\|Drug: Sarilumab\|Drug: Local standard venous thromboprophylaxis\|Drug: Therapeutic anticoagulation\|Drug: Conventional low dose thromboprophylaxis\|Drug: Intermediate dose thromboprophylaxis\|Drug: Continuation of therapeutic dose anticoagulation\|Other: No immunoglobulin\|Biological: Convalescent plasma\|Biological: Delayed administration of convalescent plasma\|Other: No vitamin C\|Drug: Vitamin C\|Other: No antiplatelet\|Drug: Aspirin\|Drug: P2Y12 inhibitor\|Other: No simvastatin\|Drug: Simvastatin\|Other: Placebo\|Drug: Eritoran\|Drug: Apremilast\|Procedure: Clinician-preferred mechanical ventilation strategy\|Procedure: Protocolised mechanical ventilation strategy\|Other: No renin-angiotensin system inhibitor\|Drug: Angiotensin converting enzyme inhibitor\|Drug: Angiotensin Receptor Blockers\|Drug: ARB + DMX-200\|Other: No cysteamine\|Drug: Cysteamine Study type - Interventional Study results - No Results Available Locations - University of Florida, Jacksonville, Florida, United States\|Augusta University, Augusta, Georgia, United States\|University of Illinois Health, Chicago, Illinois, United States\|Tulane Medical Center, New Orleans, Louisiana, United States\|University of Michigan, Ann Arbor, Michigan, United States\|Memorial Sloan Kettering Cancer Center, New York, New York, United States\|Wake Forest Baptist Health, Winston-Salem, North Carolina, United States\|The Ohio State University Wexner Medical Center, Columbus, Ohio, United States\|Oregon Health and Science University, Portland, Oregon, United States\|University of Pittsburgh Medical Centre, Pittsburgh, Pennsylvania, United States\|Brown University - Rhode Island Hospital, Providence, Rhode Island, United States\|Canberra Hospital, Canberra, Australian Capital Territory, Australia\|Bankstown-Lidcombe Hospital, Bankstown, New South Wales, Australia\|Blacktown Hospital, Blacktown, New South Wales, Australia\|Campbelltown Hospital, Campbelltown, New South Wales, Australia\|Sutherland Hospital, Caringbah, New South Wales, Australia\|Concord Hospital, Concord, New South Wales, Australia\|Dubbo Base Hospital, Dubbo, New South Wales, Australia\|Northern Beaches Hospital, Frenchs Forest, New South Wales, Australia\|Nepean Hospital, Kingswood, New South Wales, Australia\|St. George Hospital, Kogarah, New South Wales, Australia\|Liverpool Hospital, Liverpool, New South Wales, Australia\|John Hunter Hospital, Newcastle, New South Wales, Australia\|Orange Health Service, Orange, New South Wales, Australia\|St Vincent's Hospital Sydney, Sydney, New South Wales, Australia\|Prince of Wales Hospital, Sydney, New South Wales, Australia\|Royal Prince Alfred Hospital, Sydney, New South Wales, Australia\|Royal North Shore Hospital, Sydney, New South Wales, Australia\|Wollongong Hospital, Sydney, New South Wales, Australia\|Wagga Wagga Base Hospital, Wagga Wagga, New South Wales, Australia\|Westmead Hospital, Westmead, New South Wales, Australia\|Royal Darwin Hospital,, Darwin, Northern Territory, Australia\|Sunshine Coast University Hospital, Birtinya, Queensland, Australia\|The Prince Charles Hospital, Brisbane, Queensland, Australia\|Mater Hospital Brisbane, Brisbane, Queensland, Australia\|Princess Alexandra Hospital, Brisbane, Queensland, Australia\|Caboolture Hospital, Caboolture, Queensland, Australia\|Queen Elizabeth II Jubilee Hospital, Coopers Plains, Queensland, Australia\|Logan Hospital, Logan, Queensland, Australia\|Redcliffe Hospital, Redcliffe, Queensland, Australia\|Rockhampton Hospital, Rockhampton, Queensland, Australia\|Gold Coast University Hospital, Southport, Queensland, Australia\|Toowoomba Hospital, Toowoomba, Queensland, Australia\|Townsville Hospital, Townsville, Queensland, Australia\|Royal Adelaide Hospital, Adelaide, South Australia, Australia\|The Queen Elizabeth Hospital, Adelaide, South Australia, Australia\|Lyell McEwin Hospital, Adelaide, South Australia, Australia\|Flinders Medical Centre, Bedford Park, South Australia, Australia\|Launceston Hospital, Launceston, Tasmania, Australia\|Ballarat Base Hospital, Ballarat, Victoria, Australia\|Bendigo Hospital, Bendigo, Victoria, Australia\|Casey Hospital, Berwick, Victoria, Australia\|Box Hill Hospital, Box Hill, Victoria, Australia\|Monash Medical Centre, Clayton, Victoria, Australia\|Dandenong Hospital, Dandenong, Victoria, Australia\|Angliss Hospital, Ferntree Gully, Victoria, Australia\|Footscray Hospital, Footscray, Victoria, Australia\|University Hosptial Geelong, Geelong, Victoria, Australia\|The Alfred Hospital, Melbourne, Victoria, Australia\|Royal Melbourne Hospital, Melbourne, Victoria, Australia\|St Vincent's Hospital Melbourne, Melbourne, Victoria, Australia\|Maroondah Hospital, Ringwood East, Victoria, Australia\|Sunshine Hospital, Sunshine, Victoria, Australia\|Werribee Mercy Hospital, Werribee, Victoria, Australia\|St John of God Hospital Midland, Midland, Western Australia, Australia\|St John of God Hospital Murdoch, Murdoch, Western Australia, Australia\|Royal Perth Hospital, Perth, Western Australia, Australia\|Sir Charles Gairdner Hospital, Perth, Western Australia, Australia\|Fiona Stanley Hospital, Perth, Western Australia, Australia\|St John of God Subiaco, Subiaco, Western Australia, Australia\|AZ Sint-Jan, Brugge, Belgium\|CHU de Charleroi - Hôpital Civil Marie Curie, Charleroi, Belgium\|Universitair Ziekenhuis Antwerp, Edegem, Belgium\|Universitair Ziekenhuis Gent, Gent, Belgium\|Foothills Medical Centre, Calgary, Alberta, Canada\|Peter Lougheed Centre, Calgary, Alberta, Canada\|Rockyview General Hospital, Calgary, Alberta, Canada\|South Health Campus, Calgary, Alberta, Canada\|Royal Alexandra Hospital, Alberta, Edmonton, Alberta, Canada\|University of Alberta Hospital, Edmonton, Alberta, Canada\|Surrey Memorial Hospital, Surrey, British Columbia, Canada\|St Boniface General Hospital, Winnipeg, Manitoba, Canada\|Health Sciences Centre Winnipeg, Winnipeg, Manitoba, Canada\|Grace Hospital, Winnipeg, Manitoba, Canada\|Dr. Everett Chalmers Regional Hospital, Fredericton, New Brunswick, Canada\|The Moncton Hospital, Fredericton, New Brunswick, Canada\|The Saint John General Hospital, Fredericton, New Brunswick, Canada\|William Osler Health System, Brampton, Ontario, Canada\|Brantford General Hospital, Brantford, Ontario, Canada\|Hamilton general Hospital, Hamilton, Ontario, Canada\|Juravinski Hospital, Hamilton, Ontario, Canada\|St. Joseph's Healthcare Hamilton, Hamilton, Ontario, Canada\|Kingston Health Sciences Centre, Kingston, Ontario, Canada\|Grand River Hospital, Kitchener, Ontario, Canada\|St Mary's General Hospital, Kitchener, Ontario, Canada\|The Ottawa Hospital, Ottawa, Ontario, Canada\|Niagara Health, Saint Catharines, Ontario, Canada\|Thunder Bay General Hospital, Thunder Bay, Ontario, Canada\|Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada\|St. Michael's Hospital Unity Health Toronto, Toronto, Ontario, Canada\|Mount Sinai Hospital, Toronto, Ontario, Canada\|Toronto General Hospital, Toronto, Ontario, Canada\|Toronto Western Hospital, Toronto, Ontario, Canada\|St Joseph's Health Centre, Toronto, Ontario, Canada\|CIUSS Chaudieres-Appalaches (Levis), Lévis, Quebec, Canada\|Hospital Maisonneuve-Rosemont, Montréal, Quebec, Canada\|Hôpital Fleury, Montréal, Quebec, Canada\|Centre Hospitalier de l'Universite de Montreal, Montréal, Quebec, Canada\|McGill University Health Centre, Montréal, Quebec, Canada\|Hopital du Sacre-Coeur de Montreal, Montréal, Quebec, Canada\|CHU de Québec - Université Laval, Québec, Quebec, Canada\|IUCPQ-UL, Québec, Quebec, Canada\|Centre Hospitalier de l'Université de Sherbrooke, Sherbrooke, Quebec, Canada\|Regina General Hospital, Saskatoon, Saskatchewan, Canada\|Universidad de La Sabana, Chía, Cundinamarca, Colombia\|General County Hospital Požega, Požega, Croatia\|University Hospital Centre Zagreb, Zagreb, Croatia\|University Hospital for Infectious Diseases, Zagreb, Croatia\|Charité - Universitätsmedizin Berlin - Infektiologie und Pneumologie, Berlin, Germany\|Charité - Universitätsmedizin Berlin - Nephrologie, Berlin, Germany\|Vivantes Klinikum Neukölln, Berlin, Germany\|Universitätsklinikum Köln, Cologne, Germany\|Universitätsklinikum Frankfurt, Frankfurt, Germany\|University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany\|Medizinische Hochschule Hannover, Hannover, Germany\|Universitätsklinikum Jena, Jena, Germany\|Universitätsklinikum Leipzig, Leipzig, Germany\|Universitäts Klinikum Tübingen, Tübingen, Germany\|Universitätsklinikum Würzburg, Würzburg, Germany\|Jósa András County Hospital, Nyíregyháza, Hungary\|Csolnoky Ferenc Kórház - Veszprem County Hospital, Veszprém, Hungary\|Almási Balogh Pál Kórház, Ózd, Hungary\|Apollo Main Hospital, Chennai, Tamil Nadu, India\|Apollo First Med Hospital, Chennai, Tamil Nadu, India\|Apollo Vanagaram Hospital, Chennai, Tamil Nadu, India\|Apollo Speciality Hospital - OMR, Chennai, Tamil Nadu, India\|Beaumont Hospital, Dublin, Ireland\|St. Vincent's University Hospital, Dublin, Ireland\|University Hospital Galway, Galway, Ireland\|St Marianna University School of Medicine, Kawasaki, Kanagawa, Japan\|Yokohama City University Hospital, Yokohama, Kanagawa, Japan\|St. Marianna University Yokohama City Seibu Hospital, Yokohama, Kanagawa, Japan\|Saiseikai Kumamoto Hospital, Minami, Kumamoto, Japan\|Osaka City General Hospital, Osaka, Japan\|Nerima Hikarigaoka Hospital, Tokyo, Japan\|Tokyo Metropolitan Bokutoh Hospital, Tokyo, Japan\|Itabashi Chuo Medical Center, Tokyo, Japan\|Tokyo bay Urayasu-Ichikawa Medical Center, Tokyo, Japan\|Wakayama Medical University, Wakayama, Japan\|Chitwan Medical College, Bharatpur, Nepal\|Grande International Hospital, Kathmandu, Nepal\|Hospital for Advanced Medicine and Surgery (HAMS), Kathmandu, Nepal\|Nepal Mediciti, Kathmandu, Nepal\|Meander Medisch Centrum, Amersfoort, Netherlands\|Jeroen Bosch Ziekenhuis, Den Bosch, Netherlands\|Martini Hospital Groningen, Groningen, Netherlands\|University Medical Center Groningen, Groningen, Netherlands\|Leiden University Medical Center, Leiden, Netherlands\|Canisius Wilhelmina Ziekenhuis, Nijmegen, Netherlands\|Radboud University Medical Center, Nijmegen, Netherlands\|University Medical Center Utrecht, Utrecht, Netherlands\|North Shore Hospital, Auckland, New Zealand\|CVICU, Auckland City Hospital, Auckland, New Zealand\|DCCM, Auckland City Hospital, Auckland, New Zealand\|Middlemore Hospital, Auckland, New Zealand\|Christchurch Hospital, Christchurch, New Zealand\|Waikato Hospital, Hamilton, New Zealand\|Taranaki Base Hospital, New Plymouth, New Zealand\|Rotorua Hospital, Rotorua, New Zealand\|Tauranga Hospital, Tauranga, New Zealand\|Wellington Regional Hospital, Wellington, New Zealand\|Whangarei Hospital, Whangarei, New Zealand\|Ziauddin University Hospital Clifton Campus, Karachi, Sindh, Pakistan\|Abbasi Shaheed Hospital, Karachi, Sindh, Pakistan\|National Institute of Cardiovascular Diseases, Karachi, Karachi, Sindh, Pakistan\|South City Hospital, Karachi, Karachi, Sindh, Pakistan\|Ziauddin University North Nazimabad Campus, Karachi, Sindh, Pakistan\|Centro Hospitalar do Medio Tejo, Abrantes, Portugal\|Hospital Lusíadas Lisbon, Lisboa, Portugal\|Clinical Hospital of Infectious and Tropical Diseases "Dr. Victor Babes", Bucharest, Romania\|King Abdulaziz Medical City, Riyadh, Saudi Arabia\|Institut Hospital del Mar d'Investigacions Mèdiques, Barcelona, Spain\|Hospital Universitario Reina Sofia, Córdoba, Spain\|Basildon Hospital, Basildon, England, United Kingdom\|Basingstoke and North Hampshire Hospital, Basingstoke, England, United Kingdom\|Royal United Hospital, Bath, Bath, England, United Kingdom\|Queen Elizabeth Hospital Birmingham, Birmingham, England, United Kingdom\|Birmingham City Hospital, Birmingham, England, United Kingdom\|Blackburn Hospital, Blackburn, England, United Kingdom\|Pilgrim's Hospital, Boston, England, United Kingdom\|Royal Bournemouth Hospital, Bournemouth, England, United Kingdom\|Royal Sussex County Hospital, Brighton, England, United Kingdom\|Southmead Hospital, Bristol, England, United Kingdom\|Bristol Royal Hospital, Bristol, England, United Kingdom\|Queen's Hospital, Burton, Burton on Trent, England, United Kingdom\|Royal Papworth Hospital, Cambridge, England, United Kingdom\|Addenbrookes Hospital, Cambridge, England, United Kingdom\|Cumberland Royal Infirmary, Carlisle, England, United Kingdom\|Ashford & St Peters Hospital Trust, Chertsey, England, United Kingdom\|Chesterfield Royal Hospital, Chesterfield, England, United Kingdom\|Countess of Chester Hospital, Chester, England, United Kingdom\|Colchester Hospital, Colchester, England, United Kingdom\|University Hospital Coventry, Coventry, England, United Kingdom\|North Manchester General Hospital, Crumpsall, England, United Kingdom\|Darlington Memorial Hospital, Darlington, England, United Kingdom\|Darent Valley Hospital, Dartford, England, United Kingdom\|Russells Hall Hospital, Dudley, England, United Kingdom\|University Hospital of North Durham, Durham, England, United Kingdom\|Royal Devon and Exeter Hospital, Exeter, England, United Kingdom\|Frimley Park Hospital, Frimley, England, United Kingdom\|Queen Elizabeth Hospital, Gateshead, England, United Kingdom\|Medway Maritime Hospital, Gillingham, England, United Kingdom\|James Paget Kings Lynn Hospital, Great Yarmouth, England, United Kingdom\|Royal Surrey County Hospital, Guildford, England, United Kingdom\|Northwick Park Hospital, Harrow, England, United Kingdom\|Hereford County Hospital, Hereford, England, United Kingdom\|Barnet Hospital, High Barnet, England, United Kingdom\|Huddersfield Hospital, Huddersfield, England, United Kingdom\|King George Hospital, Ilford, England, United Kingdom\|Ipswich Hospital, Ipswich, England, United Kingdom\|Kettering Hospital, Kettering, England, United Kingdom\|Leeds Teaching Hospitals NHS Trust, Leeds, England, United Kingdom\|Leicester Royal Infirmary, Leicester, England, United Kingdom\|Glenfield Hospital, Leicester, England, United Kingdom\|Lincoln County Hospital, Lincoln, England, United Kingdom\|Liverpool Heart and Chest Hospital, Liverpool, England, United Kingdom\|Alder Hey Hospital, Liverpool, England, United Kingdom\|Royal Liverpool Hospital, Liverpool, England, United Kingdom\|University Hospital Aintree, Liverpool, England, United Kingdom\|Croydon University Hospital, London, England, United Kingdom\|Royal London Hospital, London, England, United Kingdom\|Whipps Cross Hospital, London, England, United Kingdom\|Newham Hospital, London, England, United Kingdom\|St Barts Hosptial, London, England, United Kingdom\|North Middlesex Hospital, London, England, United Kingdom\|Royal Free Hospital, London, England, United Kingdom\|St Thomas' Hospital, London, England, United Kingdom\|Guy's Hospital, London, England, United Kingdom\|King's College Hospital, London, England, United Kingdom\|St George's Hospital, London, England, United Kingdom\|Royal Marsden Hospital, London, England, United Kingdom\|Ryal Brompton, London, England, United Kingdom\|Hammersmith Hospital, London, England, United Kingdom\|St Mary's Hospital, London, England, United Kingdom\|Charing Cross Hospital, London, England, United Kingdom\|Luton and Dunstable University Hospital, Luton, England, United Kingdom\|Maidstone Hospital - Maidstone and Tunbridge Wells NHS Trust, Maidstone, England, United Kingdom\|Manchester Royal Infirmary, Manchester, England, United Kingdom\|The Christie Hospital, Manchester, England, United Kingdom\|Wythenshawe Hospital, Manchester, England, United Kingdom\|Queen Elizabeth Hospital, Woolwich, Margate, England, United Kingdom\|The James Cook University Hospital, Middlesbrough, England, United Kingdom\|Milton Keynes University Hospital, Milton Keynes, England, United Kingdom\|Royal Victoria Infirmary, Newcastle, Newcastle, England, United Kingdom\|Newcastle Freeman Hospital, Newcastle, England, United Kingdom\|Northampton General Hospital, Northampton, England, United Kingdom\|Norfolk and Norwich University Hospital, Norwich, England, United Kingdom\|City Hospital Nottingham, Nottingham, England, United Kingdom\|Queen's Medical Centre - Nottingham University Hospitals NHS Trust, Nottingham, England, United Kingdom\|George Eliot Hospital, Nuneaton, England, United Kingdom\|Royal Oldham Hospital, Oldham, England, United Kingdom\|Princess Royal University Hospital, Orpington, England, United Kingdom\|John Radcliffe Hospital, Oxford, England, United Kingdom\|Derriford Hospital, Plymouth, England, United Kingdom\|Poole Hospital NHS Foundation Trust, Poole, England, United Kingdom\|Queen Alexandra Hospital - Portsmouth Hospitals NHS Trust, Portsmouth, England, United Kingdom\|Whiston Hospital, Prescot, England, United Kingdom\|Royal Preston Hospital, Preston, England, United Kingdom\|Royal Berkshire Hospital, Reading, England, United Kingdom\|Alexandra Hospital, Redditch, Redditch, England, United Kingdom\|Queen's Hospital Romford, Romford, England, United Kingdom\|Rotherham General Hospital, Rotherham, England, United Kingdom\|Salford Royal Hospital, Salford, England, United Kingdom\|Salisbury District Hospital, Salisbury, England, United Kingdom\|Royal Hallamshire Hospital, Sheffield, England, United Kingdom\|Northern General Hospital, Sheffield, England, United Kingdom\|Wexham Park Hospital, Slough, England, United Kingdom\|South Tyneside District Hospital, South Shields, England, United Kingdom\|Southampton General Hospital, Southampton, England, United Kingdom\|Stepping Hill Hospital, Stockport, England, United Kingdom\|University Hospital of North Tees, Stockton-on-Tees, England, United Kingdom\|Royal Stoke University Hospital, Stoke-on-Trent, England, United Kingdom\|Sunderland Hospital, Sunderland, England, United Kingdom\|King's Mill Hospital, Sutton In Ashfield, England, United Kingdom\|Great Western Hospital, Swindon, England, United Kingdom\|Western General Hospital, Swindon, England, United Kingdom\|Musgrove Park Hospital, Taunton, England, United Kingdom\|Torbay and South Devon Hospital, Torquay, England, United Kingdom\|Royal Cornwall Hospital, Truro, England, United Kingdom\|Tunbridge Wells Hospital - Maidstone and Tunbridge Wells NHS Trust, Tunbridge Wells, England, United Kingdom\|Harefield Hospital, Uxbridge, England, United Kingdom\|Watford General Hospital, Watford, England, United Kingdom\|Southend University Hospital, Westcliff-on-Sea, England, United Kingdom\|West Cumberland Hospital, Whitehaven, England, United Kingdom\|Royal Albert Edward Infirmary, Wigan, England, United Kingdom\|Royal Hampshire Hospital, Winchester, England, United Kingdom\|Arrow Park Hospital, Wirral, England, United Kingdom\|New Cross Hospital, Wolverhampton, England, United Kingdom\|Worcester Royal Hospital, Worcester, England, United Kingdom\|York Hospital, York, England, United Kingdom\|York Hospital, York, England, United Kingdom\|Antrim Area Hospital, Antrim, Northern Ireland, United Kingdom\|Royal Victoria Hospital, Belfast, Belfast, Northern Ireland, United Kingdom\|Mater Hospital, Belfast, Northern Ireland, United Kingdom\|Belfast City Hospital, Belfast, Northern Ireland, United Kingdom\|Altnagelvin Hospital, Derry, Northern Ireland, United Kingdom\|Aberdeen Royal Infirmary, Aberdeen, Scotland, United Kingdom\|Ninewells Hospital, Dundee, Scotland, United Kingdom\|Royal Infirmary of Edinburgh, Edinburgh, Scotland, United Kingdom\|Glasgow Royal Infirmary, Glasgow, Scotland, United Kingdom\|Queen Elizabeth University Hospital, Glasgow, Glasgow, Scotland, United Kingdom\|Royal Alexandra Hospital, Glasgow, Paisley, Scotland, United Kingdom\|Neville Hall Hospital, Abergavenny, Wales, United Kingdom\|Glan Clywd Hospital, Bodelwyddan, Wales, United Kingdom\|Princess of Wales Hospital, Bridgend, Wales, United Kingdom\|University Hospital of Wales, Cardiff, Wales, United Kingdom\|Glangwilli Hospital, Carmarthen, Wales, United Kingdom\|Grange University Hospital, Cwmbran, Wales, United Kingdom\|Royal Gwent Hospital, Newport, Wales, United Kingdom\|Royal Glamorgan Hospital, Pontyclun, Wales, United Kingdom\|Morriston Hospital, Swansea, Wales, United Kingdom\|Wrexham Maelor Hospital, Wrexham, Wales, United Kingdom Study designs - Allocation: Randomized\|Intervention Model: Factorial Assignment\|Masking: None (Open Label)\|Primary Purpose: Treatment Enrollment - 10000 Age - 18 Years and older (Adult, Older Adult) Outcome measures - All-cause mortality\|Days alive and not receiving organ support in ICU\|ICU Mortality\|ICU length of stay\|Hospital length of stay\|Ventilator free days\|Organ failure free days\|Health-related Quality of life assessment\|Proportion of intubated patients who receive a tracheostomy\|Destination at time of hospital discharge\|Readmission to the index ICU during the index hospitalization\|World Health Organisation 8-point ordinal scale outcome

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