Other substances

Catechin-gallocatechin-catechin

A natural polyphenolic compound.

Phase of research

Potential treatment - theoretical effect

How it helps

Antiviral

Drug status

Natural product

Supporting references

Contradictory references

AI-suggested references

Clinical trials

General information

Catechin-gallocatechin-catechin on PubChem

Synonyms

Catechin-(4alpha->8)-gallocatechin-(4alpha->8)-catechin; Catechin

Structure image - Catechin-gallocatechin-catechin

C1C(C(OC2=C1C(=CC(=C2C3C(C(OC4=C(C(=CC(=C34)O)O)C5C(C(OC6=CC(=CC(=C56)O)O)C7=CC(=C(C=C7)O)O)O)C8=CC(=C(C(=C8)O)O)O)O)O)O)C9=CC(=C(C=C9)O)O)O

Supporting references

Link	Tested on	Impact factor	Notes	Publication date
Catechin and curcumin interact with S protein of SARS-CoV2 and ACE2 of human cell membrane: insights from computational studies Spike protein ACE2 Small molecule In silico	in silico	4.00	Predicted to bind SARS-CoV-2 Spike protein, the host's ACE2 receptor or their complex (Spike's RBD/ACE2).	Jan/21/2021

AI-suggested references

Link	Publication date
Inactivation of SARS-CoV-2 by Catechins from Green Tea.	May/14/2021
Medicinal plant compounds as promising inhibitors of coronavirus (COVID-19) main protease: an in silico study.	Sep/01/2021
Identifying the natural compound Catechin from tropical mangrove plants as a potential lead candidate against 3CLpro from SARS-CoV-2: An integrated in silico approach.	Oct/13/2021
Catechin Derivatives as Inhibitor of COVID-19 Main Protease (Mpro): Molecular Docking studies unveils an opportunity against CORONA.	Nov/25/2020
Feasibility analysis and mechanism exploration of Rhei Radix et Rhizome-Schisandrae Sphenantherae Fructus (RS) against COVID-19.	May/19/2022
Phytochemical rich Himalayan Rhododendron arboreum petals inhibit SARS-CoV-2 infection in vitro.	Dec/28/2021
In silico molecular docking studies of certain commercially available flavonoids as effective antiviral agents against spike glycoprotein of SARS-CoV-2.	Nov/18/2021
Flavan-based phytoconstituents inhibit Mpro, a SARS-COV-2 molecular target, in silico.	Aug/04/2021
Epigallocatechin Gallate (EGCG), a Green Tea Polyphenol, Reduces Coronavirus Replication in a Mouse Model.	Jan/07/2021
Potential Inhibitors of SARS-CoV-2 from Neocarya macrophylla (Sabine) Prance ex F. White: Chemoinformatic and Molecular Modeling Studies for Three Key Targets	Jun/05/2022
Epigallocatechin gallate and theaflavin gallate interaction in SARS-CoV-2 spike-protein central channel with reference to the hydroxychloroquine interaction: Bioinformatics and molecular docking study	Aug/07/2020
In silico evaluation of Vitis amurensis Rupr. polyphenol compounds for their inhibition potency against CoVID-19 main enzymes Mpro and RdRp	Feb/28/2021
Quantitative in silico analysis of SARS-CoV-2 S-RBD omicron mutant transmissibility	Jan/07/2022
Prediction of COVID-19 manipulation by selective ACE inhibitory compounds of Potentilla reptant root: In silico study and ADMET profile	Sep/29/2021
Therapeutic Approach against 2019-nCoV by Inhibition of ACE-2 Receptor	Nov/12/2020
The Novel Drug Discovery to Combat COVID-19 by Repressing Important Virus Proteins Involved in Pathogenesis Using Medicinal Herbal Compounds.	Jul/09/2021
Small molecule stabilization of non-native protein-protein interactions of SARS-CoV-2 N protein as a mechanism of action against COVID-19	Dec/22/2020
Identifying the natural polyphenol catechin as a multi-targeted agent against SARS-CoV-2 for the plausible therapy of COVID-19: an integrated computational approach	Apr/06/2021
Exploring Phytochemicals of Traditional Medicinal Plants Exhibiting Inhibitory Activity Against Main Protease, Spike Glycoprotein, RNA-dependent RNA Polymerase and Non-Structural Proteins of SARS-CoV-2 Through Virtual Screening.	Jul/08/2021
GB-2 blocking the interaction between ACE2 and wild type and mutation of spike protein of SARS-CoV-2.	Aug/05/2021
Docking Characterization and in vitro Inhibitory Activity of Flavan-3-ols and Dimeric Proanthocyanidins Against the Main Protease Activity of SARS-Cov-2	Nov/30/2020
Structure-based docking, pharmacokinetic evaluation, and molecular dynamics-guided evaluation of traditional formulation against SARS-CoV-2 spike protein receptor bind domain and ACE2 receptor complex	Oct/18/2021
Molecular Docking Studies to Identify Promising Natural Inhibitors Targeting SARS-CoV-2 Nsp10-Nsp16 Protein Complex	Feb/28/2022
SARS-CoV-2 neutralizing activity of polyphenols in a special green tea extract preparation	Jun/22/2020
Investigating Fungi-Derived Bioactive Molecules as Inhibitor of the SARS Coronavirus Papain Like Protease: Computational Based Study	May/30/2020
In Silico Evaluation of Iranian Medicinal Plant Phytoconstituents as Inhibitors against Main Protease and the Receptor-Binding Domain of SARS-CoV-2.	Sep/21/2021
Plant-Based Phytochemical Screening by Targeting Main Protease of SARS-CoV-2 to Design Effective Potent Inhibitors	Jul/24/2020
Predictive medicinal metabolites from Momordica dioica against comorbidity related proteins of SARS-CoV-2 infections	May/08/2022
Green Tea Polyphenol Catechins Inhibit Coronavirus Replication and Potentiate the Adaptive Immunity and Autophagy-Dependent Protective Mechanism to Improve Acute Lung Injury in Mice.	Jun/07/2021
Significant Inactivation of SARS-CoV-2 In Vitro by a Green Tea Catechin, a Catechin-Derivative, and Black Tea Galloylated Theaflavins.	Jun/11/2021
Effects of theaflavin-gallate in-silico binding with different proteins of SARS-CoV-2 and host inflammation and vasoregulations referring an experimental rat-lung injury.	Feb/08/2022
Characterization of the Trans-Epithelial Transport of Green Tea (C. sinensis) Catechin Extracts with In Vitro Inhibitory Effect against the SARS-CoV-2 Papain-like Protease Activity	Nov/08/2021
Potential prophylactic efficacy of mast cell stabilizers against COVID-19 vaccine-induced anaphylaxis	May/07/2020

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