Other substances

Castanospermine

An indolizidine alkaloid.

Phase of research

Potential treatment - pre-clinical evidence

How it helps

Antiviral

Drug status

Natural product

2
 Supporting references
0
 Contradictory references
1
 AI-suggested references
0
 Clinical trials

General information

Castanospermine is a tetrahydroxyindolizidine alkaloid which acts as a glycosidase inhibitor. It has potential anti-HIV-1 and anti-inflammatory properties (ChEBI).

Castanospermine on DrugBank
Castanospermine on PubChem
Castanospermine on Wikipedia


 

Structure image - Castanospermine

C1CN2C[C@@H]([C@H]([C@@H]([C@H]2[C@H]1O)O)O)O

Supporting references

Link Tested on Impact factor Notes Publication date
The iminosugars celgosivir, castanospermine and UV-4 inhibit SARS-CoV-2 replication
Spike protein Small molecule In vitro 		Vero E6 cells; SARS-CoV-2 isolate USA-WA1/2020 4.06

Decreases SARS-CoV-2-induced cell death in cell culture but with lower efficacy compared to celgosivir.

 Sep/26/2020
Natural Products Database Screening for the Discovery of Naturally Occurring SARS‐Cov‐2 Spike Glycoprotein Blockers
Spike protein Small molecule In silico 		in silico 1.81

Predicted to bind SARS-CoV-2 Spike protein.

 Nov/16/2020

AI-suggested references

Link Publication date
Natural Products Database Screening for the Discovery of Naturally Occurring SARS-Cov-2 Spike Glycoprotein Blockers
Nov/16/2020
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