Other substances

Carfilzomib

An irreversible proteasome inhibitor.

Phase of research

Potential treatment - theoretical effect

How it helps

Antiviral

Drug status

Used to treat other disease

3
 Supporting references
0
 Contradictory references
7
 AI-suggested references
0
 Clinical trials

General information

Carfilzomib on PubChem

Marketed as

KYPROLIS

 

Structure image - Carfilzomib

CC(C)C[C@@H](C(=O)[C@]1(CO1)C)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC3=CC=CC=C3)NC(=O)CN4CCOCC4

Supporting references

Link Tested on Impact factor Notes Publication date
Discovering drugs to treat coronavirus disease 2019 (COVID-19).
in silico Feb/22/2020
The Host Cell ViroCheckpoint: Identification and Pharmacologic Targeting of Novel Mechanistic Determinants of Coronavirus-Mediated Hijacked Cell States
Preprint 		in silico

one of the top drugs and compounds identified by ViroTreat

 May/17/2020
Virtual screening of approved clinic drugs with main protease (3CLpro) reveals potential inhibitory effects on SARS-CoV-2
3CLpro Small molecule In silico Screening 		in silico 3.22

Predicted to inhibit the SARS-CoV-2 3C-like protease.

 Sep/10/2020

AI-suggested references

Link Publication date
Potential SARS-CoV-2 protease Mpro inhibitors: repurposing FDA-approved drugs.
Feb/09/2021
[Treatment of early relapsed plasma cells leukemia after unrelated bone marrow transplant with KRD (carfilzomib, lenalidomide and dexamethasone): a case report.]
Dec/03/2020
A combination of carfilzomib, dexamethasone, and daratumumab for treatment of adult patients with relapsed/refractory multiple myeloma in two dosing regimens: once-weekly and twice-weekly.
Mar/30/2022
Knowledge-based structural models of SARS-CoV-2 proteins and their complexes with potential drugs
Jun/30/2021
Drug Repurposing Strategy (DRS): Emerging Approach to Identify Potential Therapeutics for Treatment of Novel Coronavirus Infection
Sep/08/2021
Inferring SARS-CoV-2 functional genomics from viral transcriptome with identification of potential antiviral drugs and therapeutic targets.
Sep/08/2021
Fast Identification of Possible Drug Treatment of Coronavirus Disease-19 (COVID-19) through Computational Drug Repurposing Study
Mar/25/2022
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