Other substances

Capreomycin

A cyclic peptide antibiotic.

Phase of research

Potential treatment - pre-clinical evidence

How it helps

Antiviral

Drug status

Used to treat other disease

2
 Supporting references
0
 Contradictory references
1
 AI-suggested references
0
 Clinical trials

General information

Capreomycin is a cyclic polypeptide antibiotic used for tuberculosis treatment. It was suggested to act via bacterial translation initiation inhibition at the bacterial ribosome. The drug also binds bacterial cell wall components (NCIt).

Capreomycin on DrugBank
Capreomycin on PubChem
Capreomycin on Wikipedia

Synonyms

2,5-Diamino-N-[[15-amino-11-(2-amino-1,4,5,6-tetrahydropyrimidin-6-yl)-8-[(carbamoylamino)methylidene]-2-(hydroxymethyl)-3,6,9,12,16-pentaoxo-1,4,7,10,13-pentazacyclohexadec-5-yl]methyl]pentanamide;sulfuric acid

Marketed as

CAPASTAT; CAPASTAT SULFATE; CAPREOMYCIN; HELPOMYCIN; KAPOCIN; LYKOCIN

 

Structure image - Capreomycin

C1CN=C(NC1C2C(=O)NCC(C(=O)NC(C(=O)NC(C(=O)NC(=CNC(=O)N)C(=O)N2)CNC(=O)C(CCCN)N)CO)N)N.OS(=O)(=O)O

Supporting references

Link Tested on Impact factor Notes Publication date
Virtual screening of approved clinic drugs with main protease (3CLpro) reveals potential inhibitory effects on SARS-CoV-2
3CLpro Small molecule In silico Screening 		in silico 3.22

Predicted to inhibit the SARS-CoV-2 3C-like protease.

 Sep/10/2020
Blockers of the SARS-CoV-2 3a Channel Identified by Targeted Drug Repurposing
Small molecule In vitro 		in vitro bacteria-based assay 3.82

Displayed inhibitory activity against the potential ion channel ORF3a of SARS-CoV-2 in a bacterial model assay.

 Mar/23/2021

AI-suggested references

Link Publication date
Identification of multipotent drugs for COVID-19 therapeutics with the evaluation of their SARS-CoV2 inhibitory activity.
Apr/07/2021
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