Camptothecin

A natural alkaloid topoisomerase I inhibitor.

Phase of research

Potential treatment - theoretical effect

How it helps

Antiviral

Drug status

Natural product

1
Supporting references
0
Contradictory references
17
AI-suggested references
1
Clinical trials

General information

Camptothecin on PubChem


Synonyms

Camptothecine; CPT

 

Structure image - Camptothecin

CC[C@@]1(C2=C(COC1=O)C(=O)N3CC4=CC5=CC=CC=C5N=C4C3=C2)O


Supporting references

Link Tested on Impact factor Notes Publication date
Enhanced production of camptothecin by immobilized callus of Ophiorrhiza mungos and a bioinformatic insight into its potential antiviral effect against SARS-CoV-2
Spike protein 3CLpro RdRpol Small molecule In silico
in silico 3.82

Predicted to bind the SARS-CoV-2 3C-like protease, RNA-dependent RNA polymerase, and Spike protein.

Jan/21/2021

AI-suggested references

Link Publication date
[Transfusion of convalescent plasma from patients with COVID -19].
Feb/03/2021
Antibodies from convalescent plasma promote SARS-CoV-2 clearance in individuals with and without endogenous antibody response.
Oct/28/2020
Clinical outcomes for COVID-19 patients with diabetes mellitus treated with convalescent plasma transfusion in Wuhan, China.
Mar/06/2022
A phase 2 single center open label randomised control trial for convalescent plasma therapy in patients with severe COVID-19
Jan/19/2022
Convalescent plasma therapy in a pregnant COVID-19 patient with a dramatic clinical and imaging response: A case report.
Jul/28/2020
No SARS-CoV-2 RNA detected in the convalescent plasma of COVID-19 patients with different disease severity
Dec/20/2021
Examining the potential benefits of the influenza vaccine against SARS-CoV-2: A retrospective cohort analysis of 74,754 patients
Aug/03/2021
Comparative Safety and Efficacy of Remdesivir Versus Remdesivir Plus Convalescent Plasma Therapy (CPT) and the Effect of Timing of Initiation of Remdesivir in COVID-19 Patients: An Observational Study From North East India
Nov/28/2021
Elevated cytokines and chemokines in peripheral blood of patients with SARS-CoV-2 pneumonia treated with high-titer convalescent plasma
Oct/29/2021
Upregulated IL-6 Indicates a Poor COVID-19 Prognosis: A Call for Tocilizumab and Convalescent Plasma Treatment.
Mar/04/2021
Comparative phytochemistry of flavaglines (= rocaglamides), a group of highly bioactive flavolignans from Aglaia species (Meliaceae).
Jun/04/2021
Convalescent plasma therapy in B-cell-depleted and B-cell sufficient patients with life-threatening COVID-19 - A case series
Jul/14/2020
Feasibility of convalescent plasma therapy in severe COVID-19 patients with persistent SARS-CoV-2 viremia
May/03/2021
Convalescent plasma therapy in obese severe COVID-19 adolescents: Two cases report.
Nov/18/2021
Repurposing Didanosine as a Potential Treatment for COVID-19 Using Single-Cell RNA Sequencing Data
Apr/14/2020
Experience of Treating COVID-19 With Remdesivir and Convalescent Plasma in a Resource-Limited Setting: A Prospective, Observational Study
Jan/31/2022
Plasma exchange followed by convalescent plasma transfusion in COVID-19 patients.
Apr/20/2021

Clinical trials

ID Title Status Phase Start date Completion date
NCT05037175 Telehealth 2.0: Evaluating Effectiveness and Engagement Strategies for CPT-Text for PTSD Not yet recruiting Not Applicable Sep/30/2021 Sep/29/2024
  • Alternative id - 62509
  • Interventions - Behavioral: CPT-Text|Behavioral: Texting as Usual|Behavioral: Retention Incentive|Behavioral: Reminder as Usual
  • Study type - Interventional
  • Study results - No Results Available
  • Locations - Stanford University, Palo Alto, California, United States
  • Study designs - Allocation: Randomized|Intervention Model: Parallel Assignment|Masking: Single (Participant)|Primary Purpose: Treatment
  • Enrollment - 400
  • Age - 18 Years to 75 Years   (Adult, Older Adult)
  • Outcome measures - PTSD Checklist for DSM-5 (PCL-5)|Patient Health Questionnaire (PHQ-9)|The Brief Inventory of Psychosocial Functioning (B-IPF)|The Client Satisfaction Questionnaire (CSQ)|Working Alliance Inventory, Short Form (WAI-SF)|Behavioral Intention