Other substances

Calpeptin

An amino acid amide.

Phase of research

Potential treatment - pre-clinical evidence

How it helps

Antiviral

Drug status

Experimental

1
 Supporting references
0
 Contradictory references
4
 AI-suggested references
0
 Clinical trials

General information

Calpeptin is a calpain inhibitor (Tsujinaka et al., 1988).

Calpeptin on PubChem

 

Structure image - Calpeptin

CCCC[C@@H](C=O)NC(=O)[C@H](CC(C)C)NC(=O)OCC1=CC=CC=C1

Supporting references

Link Tested on Impact factor Notes Publication date
A drug repurposing screen identifies hepatitis C antivirals as inhibitors of the SARS-CoV2 main protease
3CLpro Enzyme assay In vitro In silico Screening 		in silico; in vitro enzyme assay 2.74

Inhibited the SARS-CoV-2 3C-like protease in vitro with IC50 of ca. 4.05 μM.

 Feb/01/2021

AI-suggested references

Link Publication date
Identification of potent small molecule inhibitors of SARS-CoV-2 entry.
Oct/23/2021
Potential Drug Discovery for COVID-19 Treatment Targeting Cathepsin L Using a Deep Learning-Based Strategy.
May/17/2022
X-ray screening identifies active site and allosteric inhibitors of SARS-CoV-2 main protease
Apr/02/2021
Anti-SARS-CoV-2 Activity of Extracellular Vesicle Inhibitors: Screening, Validation, and Combination with Remdesivir.
Sep/16/2021
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