CA521FALA
An anti-RBD (SARS-CoV-2 Spike) antibody.
General information
CA521FALA is a human monoclonal antibody neutralizing SARS-CoV-2. It binds all RBDs of a Spike trimer simultaneously and blocks their interaction with ACE2. The antibody significantly reduced viral titres and reduced lung pathology in a mouse model (Song et al., 2021).
Supporting references
| Link | Tested on | Impact factor | Notes | Publication date |
|---|---|---|---|---|
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Structure and function analysis of a potent human neutralizing antibody CA521FALA against SARS-CoV-2
Spike protein Cryo-EM Biophysical assay Animal model In vitro Antibody |
in vitro binding assay; in vitro biophysical assay; hACE2-HEK293T cells; Vero cells; cryo-EM; BALB/c mice; rhesus macaques (pharmacokinetics); SARS-CoV-2 Spike pseudotyped virus; SARS-CoV-2 strain BetaCoV/Beijing/IMEBJ01/2020 | 4.17 | The antibody neutralized SARS-CoV-2 live and pseudovirus with sub-nanomolar IC50s. It was shown to bind all RBDs of a Spike trimer simultaneously and block their interaction with ACE2. The antibody significantly reduced viral titres and reduced lung pathology in a mouse model. It was stable in murine and rhesus macaque sera. |
Apr/23/2021 |
