BNTX
An opioid receptor antagonist.
General information
BNTX is an opioid receptor antagonist (Zhang et al., 2020).
BNTX on PubChem
Synonyms
Morphinan-6-one, 17-(cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxy-7-(phenylmethylene)-, (5alpha)-
C1CC1CN2CC[C@]34[C@@H]5C(=O)/C(=C\C6=CC=CC=C6)/C[C@]3([C@H]2CC7=C4C(=C(C=C7)O)O5)O
Supporting references
| Link | Tested on | Impact factor | Notes | Publication date |
|---|---|---|---|---|
|
Heparan sulfate assists SARS-CoV-2 in cell entry and can be targeted by approved drugs in vitro
Polysaccharide Small molecule In vitro |
ACE2-GFP HEK293T cells; Calu-3 cells; Vero E6 cells; SARS-CoV-2 pseudotyped particles | 6.26 | Inhibits SARS-CoV-2 pseudovirus cell entry with IC50 of 10 μM in ACE2-GFP HEK293T cells. At 2 μM concentration the drug reduced virus-induced cytopathic effect in Vero E6 cells by ca. 70%. It might act through actin cytoskeleton metabolism disregulation. |
Nov/04/2020 |
