Other substances

Benidipine

A  dihydropyridine calcium channel blocker.

Phase of research

Potential treatment - pre-clinical evidence

How it helps

Antiviral

Drug status

Used to treat other disease

2
 Supporting references
0
 Contradictory references
1
 AI-suggested references
0
 Clinical trials

General information

Benidipine is a synthetic dihydropyridine drug, which acts as a calcium channel blocker. It is used for treatment of hypertension and anginas. It has antioxidant, cardioprotective, and antiartheriosclerotic properties (DrugBank).

Benidipine on PubChem
Benidipine on Wikipedia

Marketed as

CONIEL

 

Structure image - Benidipine

CC1=C([C@H](C(=C(N1)C)C(=O)O[C@@H]2CCCN(C2)CC3=CC=CC=C3)C4=CC(=CC=C4)[N+](=O)[O-])C(=O)OC

Supporting references

Link Tested on Impact factor Notes Publication date
Screening of FDA-approved drugs using a MERS-CoV clinical isolate from South Korea identifies potential therapeutic options for COVID-19
Preprint Screening 		VERO cells

HCl salt

 Mar/19/2020
Calcium channel blocker amlodipine besylate therapy is associated with reduced case fatality rate of COVID-19 patients with hypertension
Small molecule In vitro Cohort study 		Vero E6 cells; Huh7 cells; COVID-19 patients taking amlodipine besylate for hypertension. 6.26

(HCl salt) Inhibited (post-entry) SARS-CoV-2 replication in a dose-dependent manner in vitro with IC50 of 3.81 μM and selectivity index of >26.25 in Vero E6 cells. It also enhanced the inhibitory effect of chloroquine in vitro. 

 Dec/22/2020

AI-suggested references

Link Publication date
High-Throughput Screening of an FDA-Approved Drug Library Identifies Inhibitors against Arenaviruses and SARS-CoV-2
Sep/30/2021
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