Other substances

Baicalin

A bioactive glycosyloxyflavone.

Phase of research

Potential treatment - pre-clinical evidence

How it helps

Antiviral

Drug status

Natural product

Supporting references

Contradictory references

AI-suggested references

Clinical trials

General information

Baicalin is a natural non-steroidal anti-inflammatory drug. It is a baicalein derivate (ChEBI).

Baicalin on PubChem
Baicalin on Wikipedia

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Supporting references

Link	Tested on	Impact factor	Notes	Publication date
Discovery of baicalin and baicalein as novel, natural product inhibitors of SARS-CoV-2 3CL protease in vitro Preprint	in vitro			Apr/14/2020
Flavonoids with inhibitory activity against SARS-CoV-2 3CLpro	in vitro	4.67	In vitro screening of selected flavonoids for their SARS-CoV-2 3CLpro binding/inhibitory activity (using a synthetic peptide).	Aug/04/2020
In silico virtual screening, characterization, docking and molecular dynamics studies of crucial SARS-CoV-2 proteins RdRpol ACE2 Small molecule In silico Screening	in silico	3.31	Predicted to bind SARS-CoV-2 RNA-dependent RNA polymerase, NSP4 and NSP15 proteins.	Aug/07/2020
In silico identification and validation of natural antiviral compounds as potential inhibitors of SARS-CoV-2 methyltransferase nsp16 Small molecule In silico	in silico	3.22	Predicted to inhibit SARS-CoV-2 nsp16 methyltransferase.	Feb/16/2021
Baicalein and Baicalin Inhibit SARS-CoV-2 RNA-Dependent-RNA Polymerase RdRpol Biophysical assay Small molecule Enzyme assay In vitro In silico	in silico; in vitro biophysical assay; in vitro enzyme assay; Vero CCL-81 cells; SARS-CoV-2 strain USA-WA/2020; (VSV) SARS-CoV-2 pseudovirus	4.13	Inhibited SARS-CoV-2 RNA-dependent RNA polymerase (less potently than baicalein) and displayed antiviral activity in vitro (EC50 of 7.6 µM).	Apr/22/2021

AI-suggested references

Link	Publication date
Flavonoids as potential therapeutics against novel coronavirus disease-2019 (nCOVID-19).	Mar/08/2021
Mechanistic Aspects of Medicinal Plants and Secondary Metabolites against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2).	Jul/07/2021
Effect of Jinzhen granule on two coronaviruses: The novel SARS-CoV-2 and the HCoV-229E and the evidences for their mechanisms of action.	Sep/06/2021
Phenylbenzopyrone of Flavonoids as a Potential Scaffold to Prevent SARSCoV-2 Replication by Inhibiting its MPRO Main Protease.	Jan/29/2021
Pharmacological development of the potential adjuvant therapeutic agents against coronavirus disease 2019	Jun/23/2020
Combination of natural antivirals and potent immune invigorators: A natural remedy to combat COVID-19	Aug/15/2021
Systems pharmacological study illustrates the immune regulation, anti-infection, anti-inflammation, and multi-organ protection mechanism of Qing-Fei-Pai-Du decoction in the treatment of COVID-19.	Sep/09/2020
Study of Baicalin toward COVID-19 Treatment: In silico Target Analysis and in vitro Inhibitory Effects on SARS-CoV-2 Proteases.	Nov/12/2021
A molecular modeling approach to identify effective antiviral phytochemicals against the main protease of SARS-CoV-2	May/12/2020
Identification of potential edible mushroom as SARS-CoV-2 main protease inhibitor using rational drug designing approach	Jan/27/2022
Anti-SARS-CoV-2 activities in vitro of Shuanghuanglian preparations and bioactive ingredients.	Jul/31/2020
Pathomechanisms, therapeutic targets and potent inhibitors of some beta-coronaviruses from bench-to-bedside.	May/28/2021
Indian Ethnomedicinal Phytochemicals as Promising Inhibitors of RNA-Binding Domain of SARS-CoV-2 Nucleocapsid Phosphoprotein: An In Silico Study	Jul/02/2021
Epigallocatechin Gallate Inhibits the Uridylate-Specific Endoribonuclease Nsp15 and Efficiently Neutralizes the SARS-CoV-2 Strain	May/21/2021
Flavonoids as Promising Antiviral Agents against SARS-CoV-2 Infection: A Mechanistic Review	Apr/08/2022
Roles of flavonoids against coronavirus infection.	Jul/28/2020
Structure-activity relationship (SAR) and molecular dynamics study of withaferin-A fragment derivatives as potential therapeutic lead against main protease (Mpro) of SARS-CoV-2	Feb/28/2021
Inhibition of ACE2 Expression by Ascorbic Acid Alone and its Combinations with Other Natural Compounds	May/10/2021
Coronavirus disease 2019 drug discovery through molecular docking	Jun/05/2020
Inhibitory effects of specific combination of natural compounds against SARS-CoV-2 and its Alpha, Beta, Gamma, Delta, Kappa, and Mu variants	Jan/21/2022
In Silico Comparison of Separate or Combinatorial Effects of Potential Inhibitors of the SARS-CoV-2 Binding Site of ACE2	Jun/30/2021
Flavonoids as potential phytotherapeutics to combat cytokine storm in SARS-CoV-2	Mar/29/2020
The discovery of herbal drugs and natural compounds as inhibitors of SARS-CoV-2 infection in vitro	Dec/14/2021

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