Other substances

Azelnidipine

A dihydropyridine calcium channel blocker.

Phase of research

Potential treatment - pre-clinical evidence

How it helps

Antiviral

Drug status

Used to treat other disease

1
 Supporting references
0
 Contradictory references
0
 AI-suggested references
0
 Clinical trials

General information

Azelnidipine is a dihydropyridine calcium channel blocker used/studied for its vasodilatory properties. It has gradual onset and a long-lasting hypotensive effect. Azelnidipine was shown to have cardio-protective, neuroprotective, and anti-atherosclerotic properties and was observed to prevent insulin resistance. It is investigated for post-ischemic stroke management (DrugBank).

Azelnidipine on PubChem
Azelnidipine on Wikipedia

Marketed as

CALBLOCK

 

Structure image - Azelnidipine

CC1=C(C(C(=C(N1)N)C(=O)OC2CN(C2)C(C3=CC=CC=C3)C4=CC=CC=C4)C5=CC(=CC=C5)[N+](=O)[O-])C(=O)OC(C)C

Supporting references

Link Tested on Impact factor Notes Publication date
Identification of existing pharmaceuticals and herbal medicines as inhibitors of SARS-CoV-2 infection
3CLpro PapainLpro Enzyme assay Animal model In vitro In silico 		in silico; in vitro enzyme assay; Vero E6 cells; golden Syrian hamsters; SARS-CoV-2 clinical isolate hCoV-19/Taiwan/4/2020 9.41

Inhibited SARS-CoV-2 infection in Vero E6 cells (selectivity index of ca. 2.4).

 Jan/15/2021
Export (.csv)