Other substances

AZD8055

A protein kinase inhibitor.

Phase of research

Potential treatment - pre-clinical evidence

How it helps

Antiviral

Drug status

Experimental

1
 Supporting references
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 Contradictory references
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 AI-suggested references
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 Clinical trials

General information

AZD8055 is a mammalian target of rapamycin complex 1 and 2 dual inhibitor. It has been investigated for its pro-apoptic and antineoplastic properties (ChEBI).

AZD8055 on DrugBank
AZD8055 on PubChem
AZD8055 on Wikipedia

Synonyms

AZD-8055; [5-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[2,3-d]pyrimidin-7-yl]-2-methoxyphenyl]methanol

 

Structure image - AZD8055

C[C@H]1COCCN1C2=NC(=NC3=C2C=CC(=N3)C4=CC(=C(C=C4)OC)CO)N5CCOC[C@@H]5C

Supporting references

Link Tested on Impact factor Notes Publication date
Drug repurposing screens reveal cell-type-specific entry pathways and FDA-approved drugs active against SARS-Cov-2
Small molecule In vitro Screening 		Huh7.5 cells; Calu-3 cells; primary normal human bronchial epithelial cells; iPSC-derived AT2 cells; SARS-CoV-2 strain USA WA1/2020 8.11

Inhibited SARS-CoV-2 replication in Huh7.5 cells and also in Calu-3 cells with an SI of >3.

 Mar/23/2021
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