Other substances

Aurothioglucose

A gold-containing glucose derivate.

Phase of research

Potential treatment - pre-clinical evidence

How it helps

Antiviral

Drug status

Used to treat other disease

1
 Supporting references
0
 Contradictory references
0
 AI-suggested references
0
 Clinical trials

General information

Aurothioglucose is a drug formerly used for rheumatoid arthritis treatment. It contains a sulfhydryl group and a gold cation, which were hypothesized to inhibit adenylyl cyclase in some lymphocyte populations, leading to inhibition of mast cell degranulation, respiratory burst effect enhancement and other pro-inflammatory processes (DrugBank).

Aurothioglucose on PubChem
Aurothioglucose on Wikipedia


Synonyms

Gold thioglucose

Marketed as

RENOL; ORONOL; ROMOSOL; SOLGANAL; SOLGANAL B

 

Structure image - Aurothioglucose

C([C@@H]1[C@H]([C@@H]([C@H](C(O1)[S-])O)O)O)O.[Au+]

Supporting references

Link Tested on Impact factor Notes Publication date
A drug repurposing screen identifies hepatitis C antivirals as inhibitors of the SARS-CoV2 main protease
3CLpro Enzyme assay In vitro In silico Screening 		in silico; in vitro enzyme assay 2.74

Inhibited the SARS-CoV-2 3C-like protease in vitro with IC50 of ca. 13.32 μM.

 Feb/01/2021
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