Other substances

Astemizole

An antihistamine.

Phase of research

Potential treatment - pre-clinical evidence

How it helps

Antiviral

Drug status

Used to treat other disease

2
 Supporting references
0
 Contradictory references
0
 AI-suggested references
0
 Clinical trials

General information

Astemizole is a piperidinyl-benzimidazol derivative, which acts as a competitive inhibitor of histamine H1 receptors. It is used in the treatment of seasonal allergic rhinitis, allergic conjunctivitis, asthma, and chronic idiopathic urticaria (NCIt).

Astemizole on DrugBank
Astemizole on PubChem
Astemizole on Wikipedia

Marketed as

ACEMIZ; ALERKIN; ASTEMISON; ASTESEN; HISMANAL; HISTALONG; LERGIBRUMIZOL; STEMIZ

 

Structure image - Astemizole

COC1=CC=C(C=C1)CCN2CCC(CC2)NC3=NC4=CC=CC=C4N3CC5=CC=C(C=C5)F


 

Supporting references

Link Tested on Impact factor Notes Publication date
Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing
Small molecule In vitro Screening 		Vero E6 cells 42.78 Jul/24/2020
Astemizole as a drug to inhibit the effect of SARS-COV-2 in vitro
ACE2 Biophysical assay In vitro In silico 		in silico; in vitro biophysical assay; ACE2-HEK293T cells 2.91

The drug inhibited SARS-CoV-2 pseudovirus cell entry in vitro. It was shown to bind the host ACE2 receptor.

 Apr/29/2021
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