Other substances

Asenapine

An atypical antipsychotic drug.

Phase of research

Potential treatment - pre-clinical evidence

How it helps

Antiviral

Drug status

Used to treat other disease

1
 Supporting references
0
 Contradictory references
1
 AI-suggested references
0
 Clinical trials

General information

Asenapine is a second-generation antipsychotic agent. It is used in the treatment of schizophrenia and bipolar 1 disorder (LiverTox).

Asenapine on DrugBank
Asenapine on PubChem
Asenapine on Wikipedia

Synonyms

(R,R)-Asenapine

Marketed as

SAPHRIS; SECUADO; SYCREST

 

Structure image - Asenapine

CN1C[C@@H]2[C@@H](C1)C3=C(C=CC(=C3)Cl)OC4=CC=CC=C24

Supporting references

Link Tested on Impact factor Notes Publication date
Several FDA-Approved Drugs Effectively Inhibit SARS-CoV-2 Infection in vitro
Small molecule In vitro Screening 		BHK21-hACE2 cells; SARS-CoV-2 Spike Δ18-pseudotyped virus; SARS-CoV-2 strain BetaCoV/Shenzhen/SZTH-003/2020 4.23

The drug (hydrochloride) inhibited SARS-CoV-2 pseudovirus and live virus in vitro with IC50s of 12.88 μM (17.69 μM and 28.13 μM in different experiments) and 16.7 μM, respectively. When combined with vortioxetine and clomiphene (citrate), the observed IC50s for pre-treatment and co-treatment were 0.34 μM and 1.93 μM with SIs of ca. 43 and 8.3, respectively.

 Feb/05/2021

AI-suggested references

Link Publication date
Treatment of Catatonia with Asenapine in a Patient with Schizotypal Personality Disorder, Psychotic Depression and Septic Shock from SARSCoV- 2 - A Case Report.
Feb/27/2021
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