Aripiprazole
A quinoline atypical antipsychotic.
General information
Aripiprazole is a quinoline derivate, which is used as an atypical anti-psychotic drug in the management of schizophrenia and acute manic and mixed episodes associated with bipolar I disorders. It acts as a partial dopamine D2 receptor and serotonin 5-HT1A receptor agonist as well as potent serotonin 5-HT2A receptor antagonist (NCIt).
Aripiprazole on DrugBank
Aripiprazole on PubChem
Aripiprazole on Wikipedia
Marketed as
ABILIFY; ABILITAT; APO-ARIPIPRAZOLE; ARIPIPRAZOLE
C1CC(=O)NC2=C1C=CC(=C2)OCCCCN3CCN(CC3)C4=C(C(=CC=C4)Cl)Cl
Supporting references
| Link | Tested on | Impact factor | Notes | Publication date |
|---|---|---|---|---|
|
Screened antipsychotic drugs inhibit SARS-CoV-2 binding with ACE2 in vitro
ACE2 Biophysical assay In vitro In silico |
in silico; in vitro biophysical assay; ACE2 high-expressing HEK293T cells; ACE2-HEK293T cell membrane chromatography | 3.65 | Bound to ACE2 and cell membranes of ACE2-expressing cells and reduced SARS-CoV-2 Spike pseudotyped virus entry ratio in vitro. |
Dec/10/2020 |
