Other substances

AR-12

An ATPase inhibitor.

Phase of research

Potential treatment - pre-clinical evidence

How it helps

Antiviral

Drug status

Experimental

1
 Supporting references
0
 Contradictory references
0
 AI-suggested references
0
 Clinical trials

General information

AR-12 is a celecoxib derivative with ATPase inhibitory activity on several chaperones. It promotes protein degradation through autophagy, which can have positive effects on viral protein elimination and prevention of virus reproduction (Rayner et al., 2020). AR-12 was also shown to inhibit phosphoinositide-dependent kinase-1 and to have antineoplastic activity (NCIt).

AR-12 on PubChem
AR-12 on Wikipedia

Synonyms

AR12; OSU-03012

 

Structure image - AR-12

C1=CC=C2C(=C1)C=CC3=C2C=CC(=C3)C4=CC(=NN4C5=CC=C(C=C5)NC(=O)CN)C(F)(F)F

Supporting references

Link Tested on Impact factor Notes Publication date
AR12 (OSU-03012) suppresses GRP78 expression and inhibits SARS-CoV-2 replication
Spike protein Small molecule In vitro Mechanism 		Vero E6 cells; ADOR non-small cell lung cancer cell line; HCT116 cells (ATG16L1 T300 and A300) 4.96

AR12 was shown to decrease the SARS-CoV-2 spike protein levels and inhibit production of infectious virions in vitro. This observation was concomitant with increased autophagosome formation and chaperone protein (GRP78) degradation.

 Sep/20/2020
Export (.csv)