Aptamer-2
An anti-Spike (SARS-CoV-2) aptamer.
General information
Aptamer-2 is a synthetic ssDNA aptamer selected for its affinity for SARS-CoV-2 Spike protein/RBD using SELEX (Liu et al., 2021).
Supporting references
| Link | Tested on | Impact factor | Notes | Publication date |
|---|---|---|---|---|
|
Neutralizing aptamers block S/RBD‐ACE2 interactions and prevent host cell infection
Spike protein ACE2 DNA Biophysical assay In vitro |
in vitro binding assay; in vitro biophysical assay; ACE-293T cells; Vero E6 cells; SARS-CoV-2 Spike pseudovirus; SARS-CoV-2 strain USA-WA1/2020 | 12.96 | Aptamer-2 bound SARS-CoV-2 Spike protein/RBD in vitro, blocked its interaction with host ACE2 receptor and neutralized SARS-CoV-2 Spike pseudotyped virus with an IC50 of 53 nM. The aptamer also protected Vero E6 cell from live virus infection. |
Mar/08/2021 |
