A bromodomain and extraterminal domain inhibitor.

Phase of research

Potential treatment - pre-clinical evidence

How it helps


Drug status


Supporting references
Contradictory references
AI-suggested references
Clinical trials

General information

Apabetalone is a quinazoline drug investigated for the treatment of atherosclerosis, diabetes, and coronary artery disease (DrugBank).

Apabetalone on PubChem
Apabetalone on Wikipedia




Structure image - Apabetalone


Supporting references

Link Tested on Impact factor Notes Publication date
A SARS-CoV-2 protein interaction map reveals targets for drug repurposing
Small molecule
in silico 42.78 Apr/30/2020
Bromodomain and Extraterminal Protein Inhibitor, Apabetalone (RVX-208), Reduces ACE2 Expression and Attenuates SARS-Cov-2 Infection In Vitro
Small molecule In vitro
in vitro binding assays; Calu-3 cells; SARS-CoV-2 (strain BEI_USA-WA1/2020) 6.08

The drug downregulated ACE2 expression in various cell lines and inhibited SARS-CoV-2 infection in Calu-3 cells. It attenuated Spike protein binding in vitro.


AI-suggested references

Clinical trials

ID Title Status Phase Start date Completion date
NCT04894266 An Open-Label Study of Apabetalone in Covid Infection Recruiting Phase 2|Phase 3 Jan/14/2022 Sep/22/2022
  • Alternative id - RVX222-CS-023
  • Interventions - Drug: Apabetalone|Other: Standard of care
  • Study type - Interventional
  • Study results - No Results Available
  • Locations - University of Alberta, Edmonton, Alberta, Canada
  • Study designs - Allocation: Randomized|Intervention Model: Parallel Assignment|Masking: None (Open Label)|Primary Purpose: Treatment
  • Enrollment - 100
  • Age - 18 Years and older   (Adult, Older Adult)
  • Outcome measures - The primary endpoint of the study is the change in WHO Ordinal Scale for Clinical Improvement at Day 14|Change in WHO Ordinal Scale for Clinical Improvement at Day 28|Biomarkers of inflammation Interleukin-6|Total time of hospitalization|Biomarkers of inflammation Interleukin-8|Biomarkers of inflammation Tumor Necrosis Factor alpha