Other substances

Antipain

A protease inhibitor.

Phase of research

Potential treatment - pre-clinical evidence

How it helps

Antiviral

Drug status

Natural product

1
 Supporting references
0
 Contradictory references
0
 AI-suggested references
0
 Clinical trials

General information

Antipain is a serine protease inhibitor produced by actinobacteria (MeSH).

Antipain on DrugBank
Antipain on PubChem
Antipain on Wikipedia


 

Structure image - Antipain

CC(C)[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C=O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)O


 

Supporting references

Link Tested on Impact factor Notes Publication date
Structure-based phylogeny identifies Avoralstat as a TMPRSS2 inhibitor that prevents SARS-CoV-2 infection in mice
Small molecule Enzyme assay Peptide Animal model In vitro In silico 		in silico; in vitro enzyme assay; Calu-3 2B4 cells; hACE2-BALB/c mice; (VSV) SARS-CoV-2 Spike pseudovirus; SARS-CoV-2 live virus 11.86

Antipain inhibited TMPRSS2 in vitro with an IC50 of ca. 0.748 μM. It inhibited pseudoviral entry in Calu-3 cells only modestly. The compound significantly reduced viral replication in cell culture.

 Apr/12/2021
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