Other substances

Andrographolide

A labdane diterpenoid.

Phase of research

Potential treatment - pre-clinical evidence

How it helps

Antiviral

Drug status

Natural product

Supporting references

Contradictory references

AI-suggested references

Clinical trials

General information

Andrographolide is a natural labdane diterpenoid with anti-inflammatory and antineoplastic properties. It may also inhibit platelet aggregation (NCIt).

Andrographolide on DrugBank
Andrographolide on PubChem
Andrographolide on Wikipedia

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Supporting references

Link	Tested on	Impact factor	Notes	Publication date
Andrographolide and its fluorescent derivative inhibit the main proteases of 2019-nCoV and SARS-CoV through covalent linkage 3CLpro TCM Small molecule Enzyme assay In vitro	in vitro enzyme assay	2.99	Inhibited the SARS-CoV-2 3C-like protease in vitro via covalent binding.	Aug/25/2020

AI-suggested references

Link	Publication date
Natural Agents Modulating ACE-2: A Review of Compounds with Potential against SARS-CoV-2 Infections.	Jan/19/2021
An in-silico approach to identify the potential hot spots in SARS-CoV-2 spike RBD to block the interaction with ACE2 receptor.	May/13/2020
Andrographis paniculata (Burm. F) Wall ex Nees: Antiviral properties.	Apr/30/2021
Immunoprotective potential of Ayurvedic herb Kalmegh (Andrographis paniculata) against respiratory viral infections - LC-MS/MS and network pharmacology analysis.	Sep/20/2021
Andrographolide Derivatives Target the KEAP1/NRF2 Axis and Possess Potent Anti-SARS-CoV-2 Activity	Jan/31/2022
A Review of Medicinal Plants with Antiviral Activity Available in Bangladesh and Mechanistic Insight Into Their Bioactive Metabolites on SARS-CoV-2, HIV and HBV.	Nov/08/2021
Estimation of drug-likeness properties of GC-MS separated bioactive compounds in rare medicinal Pleione maculata using molecular docking technique and SwissADME in silico tools	Apr/24/2021
Network bioinformatics analysis provides insight into drug repurposing for COVID-19.	Mar/30/2021
Crosstalk between endoplasmic reticulum stress and anti-viral activities: A novel therapeutic target for COVID-19	Jul/01/2020
A Computational Approach Identified Andrographolide as a Potential Drug for Suppressing COVID-19-Induced Cytokine Storm.	Jun/24/2021
Inhibitory Potential of Phytochemicals on Interleukin-6-Mediated T-Cell Reduction in COVID-19 Patients: A Computational Approach	Jun/08/2021
Andrographolide binds to spike glycoprotein and RNA-dependent RNA polymerase (NSP12) of SARS-CoV-2 by in silico approach: a probable molecule in the development of anti-coronaviral drug	Jul/13/2021
Molecular docking and pharmacokinetic studies of phytocompounds from Nigerian Medicinal Plants as promising inhibitory agents against SARS-CoV-2 methyltransferase (nsp16)	May/20/2020
In silico identification of potential inhibitors against main protease of SARS-CoV-2 6LU7 from Andrographis panniculata via molecular docking, binding energy calculations and molecular dynamics simulation studies	Dec/31/2020
Anti-SARS-CoV-2 Activity of Andrographis paniculata Extract and Its Major Component Andrographolide in Human Lung Epithelial Cells and Cytotoxicity Evaluation in Major Organ Cell Representatives	Jun/23/2020
A Computational-Based Drug Repurposing Method Targeting SARS-CoV-2 and its Neurological Manifestations Genes and Signaling Pathways	Jun/18/2021
The coronavirus disease 2019 main protease inhibitor from Andrographis paniculata (Burm. f) Ness.	Oct/10/2020
Combination of system biology to probe the anti-viral activity of andrographolide and its derivative against COVID-19.	Jan/27/2021
Molecular docking unveils the potential of andrographolide derivatives against COVID-19: an in silico approach	Apr/14/2022
Leveraging knowledge of Asian herbal medicine and its active compounds as COVID-19 treatment and prevention	Nov/14/2020
A molecular dynamics simulation study of the ACE2 receptor with screened natural inhibitors to identify novel drug candidate against COVID-19.	Apr/23/2021
Deciphering the potential anti-COVID-19 active ingredients in Andrographis paniculata (Burm. F.) Nees by combination of network pharmacology, molecular docking, and molecular dynamics	Nov/11/2021
Antiviral Activities of Andrographolide and Its Derivatives: Mechanism of Action and Delivery System	Oct/28/2021
Activity of phytochemical constituents of Curcuma longa (turmeric) and Andrographis paniculata against coronavirus (COVID-19): an in silico approach.	Oct/16/2020
Computational investigation on Andrographis paniculata phytochemicals to evaluate their potency against SARS-CoV-2 in comparison to known antiviral compounds in drug trials	Jun/16/2020
Andrographolide: A Herbal-Chemosynthetic Approach for Enhancing Immunity, Combating Viral Infections, and Its Implication on Human Health	Jun/29/2021
Andrographolide as a potential inhibitor of SARS-CoV-2 main protease: an in silico approach	Mar/27/2020
Molecular encapsulation of andrographolide in 2-hydroxypropyl-beta-cyclodextrin cavity: synthesis, characterization, pharmacokinetic and in vitro antiviral activity analysis against SARS-CoV-2.	Aug/09/2021
Molecular docking analysis of Withaferin A from Withania somnifera with the Glucose regulated protein 78 (GRP78) receptor and the SARS-CoV-2 main protease.	Apr/30/2020
Structure-based drug designing for potential antiviral activity of selected natural products from Ayurveda against SARS-CoV-2 spike glycoprotein and its cellular receptor	May/24/2020
Ethnomedicines of Indian origin for combating COVID-19 infection by hampering the viral replication: using structure-based drug discovery approach	Jun/23/2020
Molecular basis for drug repurposing to study the interface of the S protein in SARS-CoV-2 and human ACE2 through docking, characterization, and molecular dynamics for natural drug candidates.	Nov/11/2020
Artemether, Artesunate, Arteannuin B, Echinatin, Licochalcone B and Andrographolide Effectively Inhibit SARS-CoV-2 and Related Viruses In Vitro	Aug/30/2021

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