Other substances

Amphotericin B

A polyene antifungal.

Phase of research

Potential treatment - theoretical effect

How it helps

Antiviral

Drug status

Used to treat other disease

Supporting references

Contradictory references

AI-suggested references

Clinical trials

General information

Amphotericin B on PubChem

Marketed as

ABELECT; AMBISOME; AMPHO-MORONAL; AMPHOCIL; AMPHOCIN; AMPHOTEC; AMPHOTERICIN; AMPHOTERICIN B; FUNGILIN; FUNGISOME; FUNGIZONE INTRAVENOUS; HALIZON

C[C@H]1/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@@H](C[C@H]2[C@@H]([C@H](C[C@](O2)(C[C@H](C[C@H]([C@@H](CC[C@H](C[C@H](CC(=O)O[C@H]([C@@H]([C@@H]1O)C)C)O)O)O)O)O)O)O)C(=O)O)O[C@H]3[C@H]([C@H]([C@@H]([C@H](O3)C)O)N)O

Supporting references

Link	Tested on	Impact factor	Notes	Publication date
Repurposing of the approved small molecule drugs in order to inhibit SARS-CoV-2 S protein and human ACE2 interaction through virtual screening approaches Spike protein Small molecule In silico	in silico	3.22	Predicted to inhibit the SARS-CoV-2 spike protein binding to the host's ACE2 receptor.	Sep/24/2020
Step toward repurposing drug discovery for COVID‐19 therapeutics through in silico approach Spike protein 3CLpro PapainLpro RdRpol nsp3 nsp16 nsp9 nsp10 nsp4 Helicase (nsp19) Small molecule In silico	in silico	1.90	Predicted to bind the SARS-CoV-2 RNA-dependent RNA polymerase.	Nov/10/2020

AI-suggested references

Link	Publication date
Dissolving microneedle patches loaded with amphotericin B microparticles for localised and sustained intradermal delivery: Potential for enhanced treatment of cutaneous fungal infections.	Mar/16/2021
Drug repurposing of triazoles against mucormycosis using molecular docking: A short communication.	Jul/31/2021
Adjunctive use of saturated solution of potassium iodide (SSKI) with liposomal amphotericin B (L-AMB) in mucormycosis achieves favorable response, shortened dose and duration of amphotericin: A retrospective study from a COVID-19 tertiary care center.	Sep/16/2021
Nebulized Amphotericin B in Mechanically Ventilated COVID-19 Patients to Prevent Invasive Pulmonary Aspergillosis: A Retrospective Cohort Study	May/09/2022
Bat SARS-Like WIV1 coronavirus uses the ACE2 of multiple animal species as receptor and evades IFITM3 restriction via TMPRSS2 activation of membrane fusion	Jan/07/2020
Amphotericin B as antiviral drug: Possible efficacy against COVID-19.	Jun/18/2020
LY6E Restricts Entry of Human Coronaviruses, Including Currently Pandemic SARS-CoV-2	Jul/23/2020
Endogenous Fungal Endophthalmitis in a Patient Admitted to Intensive Care and Treated with Systemic Steroid for COVID-19	Feb/29/2020
Computational View toward the Inhibition of SARS-CoV-2 Spike Glycoprotein and the 3CL Protease	Apr/08/2022
Retrobulbar injection of amphotericin B using intravenous cannula for post-COVID-19 rhino-orbital mucormycosis	Aug/16/2021
Mini-Factor H Modulates Complement-Dependent IL-6 and IL-10 Release in an Immune Cell Culture (PBMC) Model: Potential Benefits Against Cytokine Storm.	Apr/28/2021
Repurposing of the approved small molecule drugs in order to inhibit SARS-CoV-2 S protein and human ACE2 interaction through virtual screening approaches	Nov/01/2020

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