Other substances

Amentoflavone

A flavonoid.

Phase of research

Potential treatment - theoretical effect

How it helps

Antiviral

Drug status

Natural product

Supporting references

Contradictory references

AI-suggested references

Clinical trials

General information

Amentoflavone on PubChem

Structure image - Amentoflavone

C1=CC(=CC=C1C2=CC(=O)C3=C(O2)C(=C(C=C3O)O)C4=C(C=CC(=C4)C5=CC(=O)C6=C(C=C(C=C6O5)O)O)O)O

Supporting references

Link	Tested on	Impact factor	Notes	Publication date
Screening of phytochemicals as potent inhibitor of 3-chymotrypsin and papain-like proteases of SARS-CoV2: an in silico approach to combat COVID-19 3CLpro PapainLpro In silico	in silico	3.22	Predicted to inhibit the SARS-CoV-2 3C-like and Papain-like proteases.	Oct/22/2020
Computer aided identification of potential SARS CoV-2 main protease inhibitors from diterpenoids and biflavonoids of Torreya nucifera leaves 3CLpro Small molecule In silico	in silico	3.22	Predicted to have a higher binding affinity to the SARS-CoV-2 3C-like protease than N3 or lopinavir.	Nov/03/2020
Biflavonoids from Rhus succedanea as probable natural inhibitors against SARS-CoV-2: a molecular docking and molecular dynamics approach 3CLpro Small molecule In silico	in silico	3.22	Predicted to inhibit the SARS-CoV-2 3C-like protease.	Dec/10/2020
In silico identification and validation of natural antiviral compounds as potential inhibitors of SARS-CoV-2 methyltransferase nsp16 Small molecule In silico	in silico	3.22	Predicted to inhibit SARS-CoV-2 nsp16 methyltransferase.	Feb/16/2021

AI-suggested references

Link	Publication date
Discovery of Some Antiviral Natural products to fight against Novel Corona Virus (SARS-CoV-2) using Insilico approach.	Dec/22/2021
Investigation of the inhibitory activity of some dietary bioactive flavonoids against SARS-CoV-2 using molecular dynamics simulations and MM-PBSA calculations.	May/07/2020
Natural biflavonoids as potential therapeutic agents against microbial diseases.	Mar/20/2021
Molecular Docking and Dynamics Simulation of Natural Phenolic Compounds with GSK-3beta: A Putative Target to Combat Mortality in Patients with COVID-19.	Aug/03/2022
Natural Products with tandem Anti-inflammatory, Immunomodulatory and Anti-SARS-CoV/2 effects: A Drug Discovery Perspective against SARS-CoV-2.	Jul/28/2021
MD simulation and MM/PBSA identifies phytochemicals as bifunctional inhibitors of SARS-CoV-2.	Aug/27/2021
Structural basis for the inhibition of SARS-CoV2 main protease by Indian medicinal plant-derived antiviral compounds	May/19/2020
Computational assessment of select antiviral phytochemicals as potential SARS-Cov-2 main protease inhibitors: molecular dynamics guided ensemble docking and extended molecular dynamics.	Jul/19/2021
The Novel Drug Discovery to Combat COVID-19 by Repressing Important Virus Proteins Involved in Pathogenesis Using Medicinal Herbal Compounds.	Jul/09/2021
Computational and Network Pharmacology Analysis of Bioflavonoids as Possible Natural Antiviral Compounds in Covid-19	Dec/23/2020
Exploring Phytochemicals of Traditional Medicinal Plants Exhibiting Inhibitory Activity Against Main Protease, Spike Glycoprotein, RNA-dependent RNA Polymerase and Non-Structural Proteins of SARS-CoV-2 Through Virtual Screening.	Jul/08/2021
In vitro testing and computational analysis of specific phytochemicals with antiviral activities considering their possible applications against COVID-19	Feb/10/2022
Insights Into Amentoflavone: A Natural Multifunctional Biflavonoid	Sep/25/2021
In Silico Screening of Natural Products as Potential Inhibitors of SARS-CoV-2 Using Molecular Docking Simulation	Mar/15/2022
Roles of flavonoids against coronavirus infection.	Jul/28/2020
Potential natural products that target the SARS-CoV-2 spike protein identified by structure-based virtual screening, isothermal titration calorimetry and lentivirus particles pseudotyped (Vpp) infection assay	Sep/16/2021
Combined use of the hepatitis C drugs and amentoflavone could interfere with binding of the spike glycoprotein of SARS-CoV-2 to ACE2: the results of a molecular simulation study	Oct/11/2021
Theobroma cacao L. compounds: Theoretical study and molecular modeling as inhibitors of main SARS-CoV-2 protease.	May/24/2021