Other substances

Almitrine

A respiratory stimulant.

Phase of research

Potential treatment - clinical evidence

How it helps

Antiviral

Drug status

Used to treat other disease

3
 Supporting references
0
 Contradictory references
3
 AI-suggested references
3
 Clinical trials

General information

Almitrine is a respiratory stimulant that improves oxygenation via carotid body chemoreceptor activation (NCIt).

Almitrine on DrugBank
Almitrine on PubChem
Almitrine on Wikipedia

Marketed as

DUXIL; VECTARION

 

Structure image - Almitrine

C=CCNC1=NC(=NC(=N1)N2CCN(CC2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F)NCC=C

Supporting references

Link Tested on Impact factor Notes Publication date
Almitrine as a non ventilatory strategy to improve intrapulmonary shunt in COVID-19 patients
Patients 2.71

almitrine infusion is associated with improved oxygenation

 Jun/04/2020
Identification of potential treatments for COVID-19 through artificial intelligence-enabled phenomic analysis of human cells infected with SARS-CoV-2
Preprint 		human renal cortical epithelial cells

strong effect

 Apr/23/2020
"Almitrine Infusion in Severe Acute Respiratory Syndrome Coronavirus 2-Induced Acute Respiratory Distress Syndrome A Single-Center Observational Study"
ARDS Small molecule Cohort study 		Patients with ARDS 7.41

Improvement in oxygenation in some COVID-19 patients with ARDS. Sample size: 32. Dosage: 1.65 ± 0.4 μg/kg/min (mean) for 2 days (median).

 Oct/21/2020

AI-suggested references

Link Publication date
Rescue therapy with inhaled nitric oxide and almitrine in COVID-19 patients with severe acute respiratory distress syndrome.
Nov/04/2020
Use of Almitrine and Inhaled Nitric Oxide in ARDS Due to COVID-19
Jul/01/2021
Almitrine for COVID-19 critically ill patients - a vascular therapy for a pulmonary vascular disease: Three case reports
May/19/2021

Clinical trials

ID Title Status Phase Start date Completion date
NCT04380727 Almitrine and COVID-19 Related Hypoxemia Completed Mar/20/2020 Apr/25/2020
  • Alternative id - 2020PI080_2
  • Interventions -
  • Study type - Observational
  • Study results - No Results Available
  • Locations - Centre Hospitalier Universitaire NANCY, Vandoeuvre-les-Nancy, France
  • Study designs - Observational Model: Case-Control|Time Perspective: Prospective
  • Enrollment - 17
  • Age - 18 Years and older   (Adult, Older Adult)
  • Outcome measures - Changes from baseline PaO2 (mmHg)|Changes from baseline ScvO2 (%)
NCT04357457 Efficacy of Intravenous Almitrine in Reducing the Need for Mechanical Ventilation in Patients With Hypoxemic Acute Respiratory Failure Due to Covid-19-related Pneumonia Active, not recruiting Phase 3 Sep/03/2020 Oct/01/2021
  • Alternative id - APHP200461|2020-001909-22
  • Interventions - Drug: Almitrine|Drug: Placebo
  • Study type - Interventional
  • Study results - No Results Available
  • Locations - Hospital Pitié-Salpêtrière, Paris, France
  • Study designs - Allocation: Randomized|Intervention Model: Parallel Assignment|Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)|Primary Purpose: Treatment
  • Enrollment - 181
  • Age - 18 Years to 80 Years   (Adult, Older Adult)
  • Outcome measures - Rate of endotracheal intubation|28-day mortality|In-hospital mortality|Number of ventilator-free days|Number of days in the ICU|Number of days in the hospital|Discontinuation rate of the treatment
NCT05216575 Almitrine in COVID-19 Patients With ARDS Treated by HFNO Recruiting Jan/01/2021 Mar/31/2022
  • Alternative id - 22reamedcovid01
  • Interventions - Drug: Administration of Almitrine
  • Study type - Observational
  • Study results - No Results Available
  • Locations - CHU de NICE, Nice, France
  • Study designs - Observational Model: Cohort|Time Perspective: Retrospective
  • Enrollment - 50
  • Age - 18 Years and older   (Adult, Older Adult)
  • Outcome measures - Almitrine-induced increase in Pa02/FiO2 ratio.|Proportion of patients requiring intubation|Proportion of patients exhibiting right ventricular failure and/or right ventricular dilation and/or acute core pulmonale after administration of Almitrine.|Clinical prediction of Almitrine effects|Radiological prediction of Almitrine effects
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