Other substances

Adenosine diphosphate ribose

A purine nucleotide sugar.

Phase of research

Potential treatment - theoretical effect

How it helps

Antiviral

Drug status

Natural product

Supporting references

Contradictory references

AI-suggested references

Clinical trials

General information

Adenosine diphosphate ribose on PubChem

Synonyms

ADP-ribose; (Rib5)ppA

Structure image - Adenosine diphosphate ribose

C1=NC(=C2C(=N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OCC4C(C(C(O4)O)O)O)O)O)N

Supporting references

Link	Tested on	Impact factor	Notes	Publication date
Drug similarity and structure-based screening of medicinal compounds to target macrodomain-I from SARS-CoV-2 to rescue the host immune system: a molecular dynamics study nsp3 Small molecule In silico	in silico	3.22	Predicted to bind the SARS-CoV-2 nsp3 macrodomain-I (Mac1/X-domain).	Sep/08/2020

AI-suggested references

Link	Publication date
Role of Poly(ADP-ribose) Polymerase (PARP1) in Viral Infection and its Implication in SARS-CoV-2 Pathogenesis.	Jan/27/2021
In silico evaluation of food-derived carotenoids against SARS-CoV-2 drug targets: Crocin is a promising dietary supplement candidate for COVID-19.	Oct/22/2020
The potential role of the combined PARP-1 and VEGF inhibition in severe SARS-CoV-2 (COVID-19) infection.	Jan/31/2022
High-Throughput Screening and Quantum Mechanics for Identifying Potent Inhibitors Against Mac1 Domain of SARS-CoV-2 Nsp3.	Aug/06/2021
An integrative drug repositioning framework discovered a potential therapeutic agent targeting COVID-19	Apr/24/2021
The SARS-CoV-2 Conserved Macrodomain Is a Mono-ADP-Ribosylhydrolase	Jan/13/2021
1H, 13C, and 15N backbone chemical shift assignments of the apo and the ADP-ribose bound forms of the macrodomain of SARS-CoV-2 non-structural protein 3b	Aug/14/2020
Crystal structures of SARS-CoV-2 ADP-ribose phosphatase: from the apo form to ligand complexes	Feb/13/2021
Molecular Basis for ADP-Ribose Binding to the Mac1 Domain of SARS-CoV-2 nsp3.	Jun/29/2020
1H,13C and 15N chemical shift assignments of the SUD domains of SARS-CoV-2 non-structural protein 3c: "the N-terminal domain-SUD-N".	Nov/23/2020
In Silico Identification of Potential Inhibitors of ADP-Ribose Phosphatase of SARS-CoV-2 nsP3 by Combining E-Pharmacophore- and Receptor-Based Virtual Screening of Database.	Aug/11/2020
Comparison of the Efficacy and Safety of PARP Inhibitors as a Monotherapy for Platinum-Sensitive Recurrent Ovarian Cancer: A Network Meta-Analysis	Nov/24/2021
Unique Mutations in the Murine Hepatitis Virus Macrodomain Differentially Attenuate Virus Replication, Indicating Multiple Roles for the Macrodomain in Coronavirus Replication.	Apr/27/2020
Reappraisal of trifluperidol against Nsp3 as a potential therapeutic for novel COVID-19: a molecular docking and dynamics study	Jul/13/2021
Essential Oils as Antiviral Agents, Potential of Essential Oils to Treat SARS-CoV-2 Infection: An In-Silico Investigation	Dec/30/2021
Structural, Biophysical, and Biochemical Elucidation of the SARS-CoV-2 Nonstructural Protein 3 Macro Domain	Oct/05/2020
Sequence homology between human PARP14 and the SARS-CoV-2 ADP ribose 1'-phosphatase	Jun/11/2020
Flavonol morin targets host ACE2, IMP-alpha, PARP-1 and viral proteins of SARS-CoV-2, SARS-CoV and MERS-CoV critical for infection and survival: a computational analysis	Aug/26/2020
Repurposing of some anti-infective drugs for COVID-19 treatment: A surveillance study supported by an in silico investigation	Dec/17/2020
Targeting SARS-CoV-2 Nsp3 macrodomain structure with insights from human poly(ADP-ribose) glycohydrolase (PARG) structures with inhibitors	Feb/23/2021
Molecular designing, crystal structure determination and in silico screening of copper(II) complexes bearing 8-hydroxyquinoline derivatives as anti-COVID-19	Aug/20/2021
beta-Carboline alkaloids induce structural plasticity and inhibition of SARS-CoV-2 nsp3 macrodomain more potently than remdesivir metabolite GS-441524: computational approach	Apr/09/2021
Discovery of Drug-Like Ligands for the Mac1 Domain of SARS-CoV-2 Nsp3	Jan/07/2021
A novel antagonist of TRPM2 and TRPV4 channels: Carvacrol	Jun/30/2020
An efficient chemical screening method for structure-based inhibitors to nucleic acid enzymes targeting the DNA repair-replication interface and SARS CoV-2.	Sep/27/2021
Immunotherapy of COVID-19 with poly (ADP-ribose) polymerase inhibitors: starting with nicotinamide	Oct/17/2020
Comparison of Binding Site of Remdesivir and Its Metabolites with NSP12-NSP7-NSP8, and NSP3 of SARS CoV-2 Virus and Alternative Potential Drugs for COVID-19 Treatment	Nov/13/2020
The SARS-CoV-2 Nsp3 macrodomain reverses PARP9/DTX3L-dependent ADP-ribosylation induced by interferon signaling.	Aug/04/2021
Discovery of compounds that inhibit SARS-CoV-2 Mac1-ADP-ribose binding by high-throughput screening	Jan/25/2022
Viral macrodomains: a structural and evolutionary assessment of the pharmacological potential	Feb/03/2022
Design, synthesis and evaluation of inhibitors of the SARS-CoV-2 nsp3 macrodomain.	May/11/2022

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