Other substances

Acetylsalicylic acid

A non-selective cyclooxygenase inhibitor.

Phase of research

Potential treatment - clinical evidence

How it helps

Other treatment

Drug status

Used to treat other disease

Supporting references

Contradictory references

AI-suggested references

Clinical trials

General information

Acetylsalicylic acid, also known as Aspirin, is a non-steroidal antiinflammatory drug with antipyretic, analgesic, and anticoagulant properties (NCIt). It is on the World Health Organization Model List of Essential Medicines.

Acetylsalicylic acid has NOT been observed to reduce the risk of death in hospitalized patients with COVID-19 in RECOVERY trial.

Acetylsalicylic acid on DrugBank
Acetylsalicylic acid on PubChem
Acetylsalicylic acid on Wikipedia

Synonyms

Aspirin; ASA

Marketed as

ACENTERINE; ACETOPHEN; ADIRO; ASPERGUM; ASPRO; DURLAZA; EASPRIN; EMPIRIN; NU-SEALS; RHODINE; RHONAL; SOLPRIN; SOLPRIN ACID; ST. JOSEPH ASPIRIN; TASPRIN

CC(=O)OC1=CC=CC=C1C(=O)O

Supporting references

Link	Tested on	Impact factor	Notes	Publication date
Aspirin Use is Associated with Decreased Mechanical Ventilation, ICU Admission, and In-Hospital Mortality in Hospitalized Patients with COVID-19 Small molecule Cohort study	Patients	4.31	After comorbidity and demographic adjustment, aspirin treatment significantly reduced the need for mechanical ventilation, ICU admission rate, and in-hospital mortality. Sample size: 98 + 314 control. Dosage: 81 mg (median) for 6 days (median).	Oct/21/2020
Dual Targeting of 3CLpro and PLpro of SARS-CoV-2: A Novel Structure-Based Design Approach to treat COVID-19 3CLpro RdRpol Small molecule In silico	in silico		Predicted to bind both the SARS-CoV-2 RNA-dependent RNA polymerase and 3C-like protease.	Dec/10/2020
Colchicine, aspirin, and montelukast – A case of successful combined pharmacotherapy for adult multisystem inflammatory syndrome in COVID-19 Small molecule Case report	A patient		Systematic clinical improvement was observed in a patient following the treatment initiation using colchicine, montelukast, and acetylsalicylic acid. Sample size: 1. Dosage: 650 mg every 4 hours.	Nov/30/2020
Oral corticoid, aspirin, anticoagulant, colchicine, and furosemide to improve the outcome of hospitalized COVID-19 patients - the COCAA-COLA cohort study Small molecule Cohort study	Non-critically ill patients	6.07	A five-day treatment with a combination of colchicine, furosemide, prednisolone, acetylsalicylic acid, and a direct anti-Xa drug resulted in a significantly better outcome compared to the control. Sample size: 28 + 40 control. Dosage: 75 mg daily for 5 days. Main outcome: Composite of 28-day mortality, high-flow oxygen therapy requirement or mechanical ventilation requirement.	Feb/09/2021
Multisystem inflammatory syndrome in adults: A rare sequela of SARS-CoV-2 infection IL-1 Severe severity Protein factor Small molecule Case report Antibody	A multisystem inflammatory syndrome patient	3.62	A patient diagnosed with multisystem inflammatory syndrome related to COVID-19 was successfully treated using high-dose methylprednisolone, anakinra, acetylsalicylic acid, and IVIg. Sample size: 1. Dosage: 325 mg daily.	May/23/2021
Multisystem Inflammatory Syndrome in Children during the COVID-19 Pandemic: A Case Report on Managing the Hyperinflammation IL-1 Severe severity Protein factor Children Small molecule Case report Antibody	A multisystem inflammatory syndrome paediatric patient	1.44	A paediatric patient diagnosed with COVID-19-related multisystem inflammatory syndrome was successfully treated using methylprednisolone, anakinra, and IVIg. Sample size: 1. Dosage: 80 mg/kg daily, then low-dose indefinitely.	Jan/30/2021

AI-suggested references

Link	Publication date
Hydroxychloroquine shortened hospital stay and reduced intensive care unit admissions in hospitalized COVID-19 patients.	Jan/31/2022
Absence of active systemic anaphylaxis in guinea pigs upon intramuscular injection of inactivated SARS-CoV-2 vaccine (Vero cells).	May/11/2022
Effect of Antiplatelet Therapy on Survival and Organ Support-Free Days in Critically Ill Patients With COVID-19: A Randomized Clinical Trial.	Mar/23/2022
Treatments Associated with Lower Mortality among Critically Ill COVID-19 Patients: A Retrospective Cohort Study.	Feb/10/2021
Aspirin as a Treatment for Acute Respiratory Distress Syndrome: a randomised placebo controlled clinical trial.	May/31/2021
Aspirin Use Is Associated With Decreased Mechanical Ventilation, Intensive Care Unit Admission, and In-Hospital Mortality in Hospitalized Patients With Coronavirus Disease 2019.	Nov/16/2021
Promising therapeutic approach for SARS-CoV-2 infection by using a rutin-based combination therapy.	May/24/2022
Associastion of In-hospital Use of Statins, Aspirin, and Renin-Angiotensin-Aldosterone Inhibitors with Mortality and ICU Admission Due to COVID-19.	Aug/10/2020
Is Acetylsalicylic Acid a Safe and Potentially Useful Choice for Adult Patients with COVID-19 ?	Jul/23/2020
Evaluation of Low-Dose Aspirin use among Critically Ill Patients with COVID-19: A Multicenter Propensity Score Matched Study	Apr/21/2021
RBD decorated PLA nanoparticle admixture with aluminum hydroxide elicit robust and long lasting immune response against SARS-CoV-2.	May/17/2022
Enhanced platelet inhibition treatment improves hypoxemia in patients with severe Covid-19 and hypercoagulability. A case control, proof of concept study	May/23/2020
Acetylsalicylic Acid Compared with Enoxaparin for the Prevention of Thrombosis and Mechanical Ventilation in COVID-19 Patients: A Retrospective Cohort Study	Jul/30/2021
Aspirin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial	Jun/17/2020
COVID-19-associated central retinal vein occlusion treated with oral aspirin	Jun/19/2020
Effect of Antithrombotic Therapy on Clinical Outcomes in Outpatients With Clinically Stable Symptomatic COVID-19: The ACTIV-4B Randomized Clinical Trial.	Oct/11/2021
Colchicine, Aspirin, and Montelukast - A Case of Successful Combined Pharmacotherapy for Adult Multisystem Inflammatory Syndrome in COVID-19	Nov/30/2020
Argatroban for Anticoagulation in Patients Requiring Venovenous Extracorporeal Membrane Oxygenation in Coronavirus Disease 2019.	Sep/07/2021
Decreased in-hospital mortality associated with aspirin administration in hospitalized patients due to severe COVID-19	May/08/2021
Carbon dioxide inhibits COVID-19-type proinflammatory responses through extracellular signal-regulated kinases 1 and 2, novel carbon dioxide sensors	Nov/06/2021
Drug repurposing for COVID-19 using graph neural network and harmonizing multiple evidence	Nov/30/2021
Effectiveness of a multidrug therapy consisting of Ivermectin, Azithromycin, Montelukast, and Acetylsalicylic acid to prevent hospitalization and death among ambulatory COVID-19 cases in Tlaxcala, Mexico.	Feb/10/2021
A novel anti-inflammatory treatment for bradykinin-induced sore throat or pharyngitis	Jun/21/2021
Mesalazine in Inflammatory Bowel Disease and COVID-19: Hospitalization and Adverse In-Hospital Outcomes Based on Nationwide Data	Feb/12/2021
Synthesis of aspirin-curcumin mimic conjugates of potential antitumor and anti-SARS-CoV-2 properties.	Nov/04/2021
NSAIDs/nitazoxanide/azithromycin repurposed for COVID-19: potential mitigation of the cytokine storm interleukin-6 amplifier via immunomodulatory effects	Jun/15/2021
Intermediate-dose anticoagulation, aspirin, and in-hospital mortality in COVID-19: A propensity score-matched analysis	Feb/22/2021
Comparative Anti-Inflammatory Effects of Salix Cortex Extracts and Acetylsalicylic Acid in SARS-CoV-2 Peptide and LPS-Activated Human In Vitro Systems	Jun/23/2021
Effect of low-dose aspirin on mortality and viral duration of the hospitalized adults with COVID-19	Aug/30/2021
An observational study of a cohort of citizens receiving the AZD1222 vaccine against SARS-CoV-2.	Jun/15/2021
Association of Early Aspirin Use With In-Hospital Mortality in Patients With Moderate COVID-19	Sep/28/2021
Hydro-ethanol extract of Holarrhena floribunda stem bark exhibits anti-anaphylactic and anti-oedematogenic effects in murine models of acute inflammation	Jul/12/2021
Mortality and pre-hospitalization use of low-dose aspirin in COVID-19 patients with coronary artery disease	Dec/18/2020

Clinical trials

ID	Title	Status	Phase	Start date	Completion date
NCT02735707	Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community- Acquired Pneumonia	Recruiting	Phase 3	Apr/11/2016	Dec/01/2025
Alternative id - U1111-1189-1653\|2015-002340-14\|602525\|16/631\|APP1101719\|158584 Interventions - Drug: Ceftriaxone\|Drug: Moxifloxacin or Levofloxacin\|Drug: Piperacillin-tazobactam\|Drug: Ceftaroline\|Drug: Amoxicillin-clavulanate\|Drug: Standard course macrolide\|Drug: Extended course macrolide\|Other: No systemic corticosteroid\|Drug: Fixed-duration Hydrocortisone\|Drug: Shock-dependent hydrocortisone\|Drug: Fixed-duration higher dose Hydrocortisone\|Other: No antiviral agent for influenza\|Drug: Five-days oseltamivir\|Drug: Ten-days oseltamivir\|Other: No antiviral agent for COVID-19\|Drug: Lopinavir / Ritonavir\|Drug: Hydroxychloroquine\|Drug: Hydroxychloroquine + lopinavir/ritonavir\|Drug: Ivermectin\|Other: No immune modulation for COVID-19\|Drug: Interferon beta-1a\|Drug: Anakinra\|Drug: Tocilizumab\|Drug: Sarilumab\|Drug: Local standard venous thromboprophylaxis\|Drug: Therapeutic anticoagulation\|Drug: Conventional low dose thromboprophylaxis\|Drug: Intermediate dose thromboprophylaxis\|Drug: Continuation of therapeutic dose anticoagulation\|Other: No immunoglobulin\|Biological: Convalescent plasma\|Biological: Delayed administration of convalescent plasma\|Other: No vitamin C\|Drug: Vitamin C\|Other: No antiplatelet\|Drug: Aspirin\|Drug: P2Y12 inhibitor\|Other: No simvastatin\|Drug: Simvastatin\|Other: Placebo\|Drug: Eritoran\|Drug: Apremilast\|Procedure: Clinician-preferred mechanical ventilation strategy\|Procedure: Protocolised mechanical ventilation strategy\|Other: No renin-angiotensin system inhibitor\|Drug: Angiotensin converting enzyme inhibitor\|Drug: Angiotensin Receptor Blockers\|Drug: ARB + DMX-200\|Other: No cysteamine\|Drug: Cysteamine Study type - Interventional Study results - No Results Available Locations - University of Florida, Jacksonville, Florida, United States\|Augusta University, Augusta, Georgia, United States\|University of Illinois Health, Chicago, Illinois, United States\|Tulane Medical Center, New Orleans, Louisiana, United States\|University of Michigan, Ann Arbor, Michigan, United States\|Memorial Sloan Kettering Cancer Center, New York, New York, United States\|Wake Forest Baptist Health, Winston-Salem, North Carolina, United States\|The Ohio State University Wexner Medical Center, Columbus, Ohio, United States\|Oregon Health and Science University, Portland, Oregon, United States\|University of Pittsburgh Medical Centre, Pittsburgh, Pennsylvania, United States\|Brown University - Rhode Island Hospital, Providence, Rhode Island, United States\|Canberra Hospital, Canberra, Australian Capital Territory, Australia\|Bankstown-Lidcombe Hospital, Bankstown, New South Wales, Australia\|Blacktown Hospital, Blacktown, New South Wales, Australia\|Campbelltown Hospital, Campbelltown, New South Wales, Australia\|Sutherland Hospital, Caringbah, New South Wales, Australia\|Concord Hospital, Concord, New South Wales, Australia\|Dubbo Base Hospital, Dubbo, New South Wales, Australia\|Northern Beaches Hospital, Frenchs Forest, New South Wales, Australia\|Nepean Hospital, Kingswood, New South Wales, Australia\|St. George Hospital, Kogarah, New South Wales, Australia\|Liverpool Hospital, Liverpool, New South Wales, Australia\|John Hunter Hospital, Newcastle, New South Wales, Australia\|Orange Health Service, Orange, New South Wales, Australia\|St Vincent's Hospital Sydney, Sydney, New South Wales, Australia\|Prince of Wales Hospital, Sydney, New South Wales, Australia\|Royal Prince Alfred Hospital, Sydney, New South Wales, Australia\|Royal North Shore Hospital, Sydney, New South Wales, Australia\|Wollongong Hospital, Sydney, New South Wales, Australia\|Wagga Wagga Base Hospital, Wagga Wagga, New South Wales, Australia\|Westmead Hospital, Westmead, New South Wales, Australia\|Royal Darwin Hospital,, Darwin, Northern Territory, Australia\|Sunshine Coast University Hospital, Birtinya, Queensland, Australia\|The Prince Charles Hospital, Brisbane, Queensland, Australia\|Mater Hospital Brisbane, Brisbane, Queensland, Australia\|Princess Alexandra Hospital, Brisbane, Queensland, Australia\|Caboolture Hospital, Caboolture, Queensland, Australia\|Queen Elizabeth II Jubilee Hospital, Coopers Plains, Queensland, Australia\|Logan Hospital, Logan, Queensland, Australia\|Redcliffe Hospital, Redcliffe, Queensland, Australia\|Rockhampton Hospital, Rockhampton, Queensland, Australia\|Gold Coast University Hospital, Southport, Queensland, Australia\|Toowoomba Hospital, Toowoomba, Queensland, Australia\|Townsville Hospital, Townsville, Queensland, Australia\|Royal Adelaide Hospital, Adelaide, South Australia, Australia\|The Queen Elizabeth Hospital, Adelaide, South Australia, Australia\|Lyell McEwin Hospital, Adelaide, South Australia, Australia\|Flinders Medical Centre, Bedford Park, South Australia, Australia\|Launceston Hospital, Launceston, Tasmania, Australia\|Ballarat Base Hospital, Ballarat, Victoria, Australia\|Bendigo Hospital, Bendigo, Victoria, Australia\|Casey Hospital, Berwick, Victoria, Australia\|Box Hill Hospital, Box Hill, Victoria, Australia\|Monash Medical Centre, Clayton, Victoria, Australia\|Dandenong Hospital, Dandenong, Victoria, Australia\|Angliss Hospital, Ferntree Gully, Victoria, Australia\|Footscray Hospital, Footscray, Victoria, Australia\|University Hosptial Geelong, Geelong, Victoria, Australia\|The Alfred Hospital, Melbourne, Victoria, Australia\|Royal Melbourne Hospital, Melbourne, Victoria, Australia\|St Vincent's Hospital Melbourne, Melbourne, Victoria, Australia\|Maroondah Hospital, Ringwood East, Victoria, Australia\|Sunshine Hospital, Sunshine, Victoria, Australia\|Werribee Mercy Hospital, Werribee, Victoria, Australia\|St John of God Hospital Midland, Midland, Western Australia, Australia\|St John of God Hospital Murdoch, Murdoch, Western Australia, Australia\|Royal Perth Hospital, Perth, Western Australia, Australia\|Sir Charles Gairdner Hospital, Perth, Western Australia, Australia\|Fiona Stanley Hospital, Perth, Western Australia, Australia\|St John of God Subiaco, Subiaco, Western Australia, Australia\|AZ Sint-Jan, Brugge, Belgium\|CHU de Charleroi - Hôpital Civil Marie Curie, Charleroi, Belgium\|Universitair Ziekenhuis Antwerp, Edegem, Belgium\|Universitair Ziekenhuis Gent, Gent, Belgium\|Foothills Medical Centre, Calgary, Alberta, Canada\|Peter Lougheed Centre, Calgary, Alberta, Canada\|Rockyview General Hospital, Calgary, Alberta, Canada\|South Health Campus, Calgary, Alberta, Canada\|Royal Alexandra Hospital, Alberta, Edmonton, Alberta, Canada\|University of Alberta Hospital, Edmonton, Alberta, Canada\|Surrey Memorial Hospital, Surrey, British Columbia, Canada\|St Boniface General Hospital, Winnipeg, Manitoba, Canada\|Health Sciences Centre Winnipeg, Winnipeg, Manitoba, Canada\|Grace Hospital, Winnipeg, Manitoba, Canada\|Dr. Everett Chalmers Regional Hospital, Fredericton, New Brunswick, Canada\|The Moncton Hospital, Fredericton, New Brunswick, Canada\|The Saint John General Hospital, Fredericton, New Brunswick, Canada\|William Osler Health System, Brampton, Ontario, Canada\|Brantford General Hospital, Brantford, Ontario, Canada\|Hamilton general Hospital, Hamilton, Ontario, Canada\|Juravinski Hospital, Hamilton, Ontario, Canada\|St. Joseph's Healthcare Hamilton, Hamilton, Ontario, Canada\|Kingston Health Sciences Centre, Kingston, Ontario, Canada\|Grand River Hospital, Kitchener, Ontario, Canada\|St Mary's General Hospital, Kitchener, Ontario, Canada\|The Ottawa Hospital, Ottawa, Ontario, Canada\|Niagara Health, Saint Catharines, Ontario, Canada\|Thunder Bay General Hospital, Thunder Bay, Ontario, Canada\|Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada\|St. Michael's Hospital Unity Health Toronto, Toronto, Ontario, Canada\|Mount Sinai Hospital, Toronto, Ontario, Canada\|Toronto General Hospital, Toronto, Ontario, Canada\|Toronto Western Hospital, Toronto, Ontario, Canada\|St Joseph's Health Centre, Toronto, Ontario, Canada\|CIUSS Chaudieres-Appalaches (Levis), Lévis, Quebec, Canada\|Hospital Maisonneuve-Rosemont, Montréal, Quebec, Canada\|Hôpital Fleury, Montréal, Quebec, Canada\|Centre Hospitalier de l'Universite de Montreal, Montréal, Quebec, Canada\|McGill University Health Centre, Montréal, Quebec, Canada\|Hopital du Sacre-Coeur de Montreal, Montréal, Quebec, Canada\|CHU de Québec - Université Laval, Québec, Quebec, Canada\|IUCPQ-UL, Québec, Quebec, Canada\|Centre Hospitalier de l'Université de Sherbrooke, Sherbrooke, Quebec, Canada\|Regina General Hospital, Saskatoon, Saskatchewan, Canada\|Universidad de La Sabana, Chía, Cundinamarca, Colombia\|General County Hospital Požega, Požega, Croatia\|University Hospital Centre Zagreb, Zagreb, Croatia\|University Hospital for Infectious Diseases, Zagreb, Croatia\|Charité - Universitätsmedizin Berlin - Infektiologie und Pneumologie, Berlin, Germany\|Charité - Universitätsmedizin Berlin - Nephrologie, Berlin, Germany\|Vivantes Klinikum Neukölln, Berlin, Germany\|Universitätsklinikum Köln, Cologne, Germany\|Universitätsklinikum Frankfurt, Frankfurt, Germany\|University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany\|Medizinische Hochschule Hannover, Hannover, Germany\|Universitätsklinikum Jena, Jena, Germany\|Universitätsklinikum Leipzig, Leipzig, Germany\|Universitäts Klinikum Tübingen, Tübingen, Germany\|Universitätsklinikum Würzburg, Würzburg, Germany\|Jósa András County Hospital, Nyíregyháza, Hungary\|Csolnoky Ferenc Kórház - Veszprem County Hospital, Veszprém, Hungary\|Almási Balogh Pál Kórház, Ózd, Hungary\|Apollo Main Hospital, Chennai, Tamil Nadu, India\|Apollo First Med Hospital, Chennai, Tamil Nadu, India\|Apollo Vanagaram Hospital, Chennai, Tamil Nadu, India\|Apollo Speciality Hospital - OMR, Chennai, Tamil Nadu, India\|Beaumont Hospital, Dublin, Ireland\|St. Vincent's University Hospital, Dublin, Ireland\|University Hospital Galway, Galway, Ireland\|St Marianna University School of Medicine, Kawasaki, Kanagawa, Japan\|Yokohama City University Hospital, Yokohama, Kanagawa, Japan\|St. Marianna University Yokohama City Seibu Hospital, Yokohama, Kanagawa, Japan\|Saiseikai Kumamoto Hospital, Minami, Kumamoto, Japan\|Osaka City General Hospital, Osaka, Japan\|Nerima Hikarigaoka Hospital, Tokyo, Japan\|Tokyo Metropolitan Bokutoh Hospital, Tokyo, Japan\|Itabashi Chuo Medical Center, Tokyo, Japan\|Tokyo bay Urayasu-Ichikawa Medical Center, Tokyo, Japan\|Wakayama Medical University, Wakayama, Japan\|Chitwan Medical College, Bharatpur, Nepal\|Grande International Hospital, Kathmandu, Nepal\|Hospital for Advanced Medicine and Surgery (HAMS), Kathmandu, Nepal\|Nepal Mediciti, Kathmandu, Nepal\|Meander Medisch Centrum, Amersfoort, Netherlands\|Jeroen Bosch Ziekenhuis, Den Bosch, Netherlands\|Martini Hospital Groningen, Groningen, Netherlands\|University Medical Center Groningen, Groningen, Netherlands\|Leiden University Medical Center, Leiden, Netherlands\|Canisius Wilhelmina Ziekenhuis, Nijmegen, Netherlands\|Radboud University Medical Center, Nijmegen, Netherlands\|University Medical Center Utrecht, Utrecht, Netherlands\|North Shore Hospital, Auckland, New Zealand\|CVICU, Auckland City Hospital, Auckland, New Zealand\|DCCM, Auckland City Hospital, Auckland, New Zealand\|Middlemore Hospital, Auckland, New Zealand\|Christchurch Hospital, Christchurch, New Zealand\|Waikato Hospital, Hamilton, New Zealand\|Taranaki Base Hospital, New Plymouth, New Zealand\|Rotorua Hospital, Rotorua, New Zealand\|Tauranga Hospital, Tauranga, New Zealand\|Wellington Regional Hospital, Wellington, New Zealand\|Whangarei Hospital, Whangarei, New Zealand\|Ziauddin University Hospital Clifton Campus, Karachi, Sindh, Pakistan\|Abbasi Shaheed Hospital, Karachi, Sindh, Pakistan\|National Institute of Cardiovascular Diseases, Karachi, Karachi, Sindh, Pakistan\|South City Hospital, Karachi, Karachi, Sindh, Pakistan\|Ziauddin University North Nazimabad Campus, Karachi, Sindh, Pakistan\|Centro Hospitalar do Medio Tejo, Abrantes, Portugal\|Hospital Lusíadas Lisbon, Lisboa, Portugal\|Clinical Hospital of Infectious and Tropical Diseases "Dr. Victor Babes", Bucharest, Romania\|King Abdulaziz Medical City, Riyadh, Saudi Arabia\|Institut Hospital del Mar d'Investigacions Mèdiques, Barcelona, Spain\|Hospital Universitario Reina Sofia, Córdoba, Spain\|Basildon Hospital, Basildon, England, United Kingdom\|Basingstoke and North Hampshire Hospital, Basingstoke, England, United Kingdom\|Royal United Hospital, Bath, Bath, England, United Kingdom\|Queen Elizabeth Hospital Birmingham, Birmingham, England, United Kingdom\|Birmingham City Hospital, Birmingham, England, United Kingdom\|Blackburn Hospital, Blackburn, England, United Kingdom\|Pilgrim's Hospital, Boston, England, United Kingdom\|Royal Bournemouth Hospital, Bournemouth, England, United Kingdom\|Royal Sussex County Hospital, Brighton, England, United Kingdom\|Southmead Hospital, Bristol, England, United Kingdom\|Bristol Royal Hospital, Bristol, England, United Kingdom\|Queen's Hospital, Burton, Burton on Trent, England, United Kingdom\|Royal Papworth Hospital, Cambridge, England, United Kingdom\|Addenbrookes Hospital, Cambridge, England, United Kingdom\|Cumberland Royal Infirmary, Carlisle, England, United Kingdom\|Ashford & St Peters Hospital Trust, Chertsey, England, United Kingdom\|Chesterfield Royal Hospital, Chesterfield, England, United Kingdom\|Countess of Chester Hospital, Chester, England, United Kingdom\|Colchester Hospital, Colchester, England, United Kingdom\|University Hospital Coventry, Coventry, England, United Kingdom\|North Manchester General Hospital, Crumpsall, England, United Kingdom\|Darlington Memorial Hospital, Darlington, England, United Kingdom\|Darent Valley Hospital, Dartford, England, United Kingdom\|Russells Hall Hospital, Dudley, England, United Kingdom\|University Hospital of North Durham, Durham, England, United Kingdom\|Royal Devon and Exeter Hospital, Exeter, England, United Kingdom\|Frimley Park Hospital, Frimley, England, United Kingdom\|Queen Elizabeth Hospital, Gateshead, England, United Kingdom\|Medway Maritime Hospital, Gillingham, England, United Kingdom\|James Paget Kings Lynn Hospital, Great Yarmouth, England, United Kingdom\|Royal Surrey County Hospital, Guildford, England, United Kingdom\|Northwick Park Hospital, Harrow, England, United Kingdom\|Hereford County Hospital, Hereford, England, United Kingdom\|Barnet Hospital, High Barnet, England, United Kingdom\|Huddersfield Hospital, Huddersfield, England, United Kingdom\|King George Hospital, Ilford, England, United Kingdom\|Ipswich Hospital, Ipswich, England, United Kingdom\|Kettering Hospital, Kettering, England, United Kingdom\|Leeds Teaching Hospitals NHS Trust, Leeds, England, United Kingdom\|Leicester Royal Infirmary, Leicester, England, United Kingdom\|Glenfield Hospital, Leicester, England, United Kingdom\|Lincoln County Hospital, Lincoln, England, United Kingdom\|Liverpool Heart and Chest Hospital, Liverpool, England, United Kingdom\|Alder Hey Hospital, Liverpool, England, United Kingdom\|Royal Liverpool Hospital, Liverpool, England, United Kingdom\|University Hospital Aintree, Liverpool, England, United Kingdom\|Croydon University Hospital, London, England, United Kingdom\|Royal London Hospital, London, England, United Kingdom\|Whipps Cross Hospital, London, England, United Kingdom\|Newham Hospital, London, England, United Kingdom\|St Barts Hosptial, London, England, United Kingdom\|North Middlesex Hospital, London, England, United Kingdom\|Royal Free Hospital, London, England, United Kingdom\|St Thomas' Hospital, London, England, United Kingdom\|Guy's Hospital, London, England, United Kingdom\|King's College Hospital, London, England, United Kingdom\|St George's Hospital, London, England, United Kingdom\|Royal Marsden Hospital, London, England, United Kingdom\|Ryal Brompton, London, England, United Kingdom\|Hammersmith Hospital, London, England, United Kingdom\|St Mary's Hospital, London, England, United Kingdom\|Charing Cross Hospital, London, England, United Kingdom\|Luton and Dunstable University Hospital, Luton, England, United Kingdom\|Maidstone Hospital - Maidstone and Tunbridge Wells NHS Trust, Maidstone, England, United Kingdom\|Manchester Royal Infirmary, Manchester, England, United Kingdom\|The Christie Hospital, Manchester, England, United Kingdom\|Wythenshawe Hospital, Manchester, England, United Kingdom\|Queen Elizabeth Hospital, Woolwich, Margate, England, United Kingdom\|The James Cook University Hospital, Middlesbrough, England, United Kingdom\|Milton Keynes University Hospital, Milton Keynes, England, United Kingdom\|Royal Victoria Infirmary, Newcastle, Newcastle, England, United Kingdom\|Newcastle Freeman Hospital, Newcastle, England, United Kingdom\|Northampton General Hospital, Northampton, England, United Kingdom\|Norfolk and Norwich University Hospital, Norwich, England, United Kingdom\|City Hospital Nottingham, Nottingham, England, United Kingdom\|Queen's Medical Centre - Nottingham University Hospitals NHS Trust, Nottingham, England, United Kingdom\|George Eliot Hospital, Nuneaton, England, United Kingdom\|Royal Oldham Hospital, Oldham, England, United Kingdom\|Princess Royal University Hospital, Orpington, England, United Kingdom\|John Radcliffe Hospital, Oxford, England, United Kingdom\|Derriford Hospital, Plymouth, England, United Kingdom\|Poole Hospital NHS Foundation Trust, Poole, England, United Kingdom\|Queen Alexandra Hospital - Portsmouth Hospitals NHS Trust, Portsmouth, England, United Kingdom\|Whiston Hospital, Prescot, England, United Kingdom\|Royal Preston Hospital, Preston, England, United Kingdom\|Royal Berkshire Hospital, Reading, England, United Kingdom\|Alexandra Hospital, Redditch, Redditch, England, United Kingdom\|Queen's Hospital Romford, Romford, England, United Kingdom\|Rotherham General Hospital, Rotherham, England, United Kingdom\|Salford Royal Hospital, Salford, England, United Kingdom\|Salisbury District Hospital, Salisbury, England, United Kingdom\|Royal Hallamshire Hospital, Sheffield, England, United Kingdom\|Northern General Hospital, Sheffield, England, United Kingdom\|Wexham Park Hospital, Slough, England, United Kingdom\|South Tyneside District Hospital, South Shields, England, United Kingdom\|Southampton General Hospital, Southampton, England, United Kingdom\|Stepping Hill Hospital, Stockport, England, United Kingdom\|University Hospital of North Tees, Stockton-on-Tees, England, United Kingdom\|Royal Stoke University Hospital, Stoke-on-Trent, England, United Kingdom\|Sunderland Hospital, Sunderland, England, United Kingdom\|King's Mill Hospital, Sutton In Ashfield, England, United Kingdom\|Great Western Hospital, Swindon, England, United Kingdom\|Western General Hospital, Swindon, England, United Kingdom\|Musgrove Park Hospital, Taunton, England, United Kingdom\|Torbay and South Devon Hospital, Torquay, England, United Kingdom\|Royal Cornwall Hospital, Truro, England, United Kingdom\|Tunbridge Wells Hospital - Maidstone and Tunbridge Wells NHS Trust, Tunbridge Wells, England, United Kingdom\|Harefield Hospital, Uxbridge, England, United Kingdom\|Watford General Hospital, Watford, England, United Kingdom\|Southend University Hospital, Westcliff-on-Sea, England, United Kingdom\|West Cumberland Hospital, Whitehaven, England, United Kingdom\|Royal Albert Edward Infirmary, Wigan, England, United Kingdom\|Royal Hampshire Hospital, Winchester, England, United Kingdom\|Arrow Park Hospital, Wirral, England, United Kingdom\|New Cross Hospital, Wolverhampton, England, United Kingdom\|Worcester Royal Hospital, Worcester, England, United Kingdom\|York Hospital, York, England, United Kingdom\|York Hospital, York, England, United Kingdom\|Antrim Area Hospital, Antrim, Northern Ireland, United Kingdom\|Royal Victoria Hospital, Belfast, Belfast, Northern Ireland, United Kingdom\|Mater Hospital, Belfast, Northern Ireland, United Kingdom\|Belfast City Hospital, Belfast, Northern Ireland, United Kingdom\|Altnagelvin Hospital, Derry, Northern Ireland, United Kingdom\|Aberdeen Royal Infirmary, Aberdeen, Scotland, United Kingdom\|Ninewells Hospital, Dundee, Scotland, United Kingdom\|Royal Infirmary of Edinburgh, Edinburgh, Scotland, United Kingdom\|Glasgow Royal Infirmary, Glasgow, Scotland, United Kingdom\|Queen Elizabeth University Hospital, Glasgow, Glasgow, Scotland, United Kingdom\|Royal Alexandra Hospital, Glasgow, Paisley, Scotland, United Kingdom\|Neville Hall Hospital, Abergavenny, Wales, United Kingdom\|Glan Clywd Hospital, Bodelwyddan, Wales, United Kingdom\|Princess of Wales Hospital, Bridgend, Wales, United Kingdom\|University Hospital of Wales, Cardiff, Wales, United Kingdom\|Glangwilli Hospital, Carmarthen, Wales, United Kingdom\|Grange University Hospital, Cwmbran, Wales, United Kingdom\|Royal Gwent Hospital, Newport, Wales, United Kingdom\|Royal Glamorgan Hospital, Pontyclun, Wales, United Kingdom\|Morriston Hospital, Swansea, Wales, United Kingdom\|Wrexham Maelor Hospital, Wrexham, Wales, United Kingdom Study designs - Allocation: Randomized\|Intervention Model: Factorial Assignment\|Masking: None (Open Label)\|Primary Purpose: Treatment Enrollment - 10000 Age - 18 Years and older (Adult, Older Adult) Outcome measures - All-cause mortality\|Days alive and not receiving organ support in ICU\|ICU Mortality\|ICU length of stay\|Hospital length of stay\|Ventilator free days\|Organ failure free days\|Health-related Quality of life assessment\|Proportion of intubated patients who receive a tracheostomy\|Destination at time of hospital discharge\|Readmission to the index ICU during the index hospitalization\|World Health Organisation 8-point ordinal scale outcome
NCT04410328	Aggrenox To Treat Acute Covid-19	Completed	Phase 3	Oct/21/2020	Oct/15/2021
Alternative id - Pro2020001469 Interventions - Drug: Dipyridamole ER 200mg/ Aspirin 25mg orally/enterally AND Standard of care\|Other: Standard of care Study type - Interventional Study results - No Results Available Locations - Rutgers New Jersey Medical School University Hospital, Newark, New Jersey, United States Study designs - Allocation: Randomized\|Intervention Model: Parallel Assignment\|Masking: None (Open Label)\|Primary Purpose: Treatment Enrollment - 99 Age - 19 Years and older (Adult, Older Adult) Outcome measures - Covid (Coronavirus Disease-19) Ordinal Scale\|Mortality\|Supplemental Oxygen\|Invasive-ventilator\|ICU stay\|Hospital stay\|Inflammatory markers\|Thromboembolic complications\|COVID ordinal scale
NCT04365309	Protective Effect of Aspirin on COVID-19 Patients	Unknown status	Phase 2\|Phase 3	Feb/10/2020	Jun/01/2020
Alternative id - Xi jingH Interventions - Drug: Aspirin 100mg Study type - Interventional Study results - No Results Available Locations - Cai Yue, Xi'an, Shaanxi, China Study designs - Allocation: Randomized\|Intervention Model: Parallel Assignment\|Masking: None (Open Label)\|Primary Purpose: Treatment Enrollment - 128 Age - 18 Years to 85 Years (Adult, Older Adult) Outcome measures - clinical recovery time (TTCR)\|the time of SARS-CoV2 overcasting
NCT04937088	Outpatient Liquid Aspirin (OLA)	Recruiting	Phase 2	Dec/06/2021	Dec/05/2022
Alternative id - 1658 Interventions - Drug: ASA Study type - Interventional Study results - No Results Available Locations - Lsuhsc-No, New Orleans, Louisiana, United States Study designs - Allocation: Randomized\|Intervention Model: Single Group Assignment\|Masking: Triple (Participant, Investigator, Outcomes Assessor)\|Primary Purpose: Other Enrollment - 200 Age - 40 Years and older (Adult, Older Adult) Outcome measures - Reduced COVID-19 related hospitalizations
NCT04466670	Hemostasis in COVID-19: an Adaptive Clinical Trial	Recruiting	Phase 2	Jul/11/2020	May/30/2022
Alternative id - 33788820.9.0000.0068 Interventions - Drug: acetylsalicylic acid\|Drug: Unfractionated heparin nebulized Study type - Interventional Study results - No Results Available Locations - Vanderson Rocha, Sao Paulo, Brazil Study designs - Allocation: Randomized\|Intervention Model: Sequential Assignment\|Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)\|Primary Purpose: Treatment Enrollment - 379 Age - 18 Years and older (Adult, Older Adult) Outcome measures - Hospital discharge - alive / death\|Length of mechanical ventilation free days\|Length of renal replacement therapy free days\|Number of documented venous thromboembolism or arterial thrombosis
NCT04363840	The LEAD COVID-19 Trial: Low-risk, Early Aspirin and Vitamin D to Reduce COVID-19 Hospitalizations	Withdrawn	Phase 2	May/01/2020	Dec/01/2020
Alternative id - 20-063 Interventions - Drug: Aspirin 81 mg\|Dietary Supplement: Vitamin D Study type - Interventional Study results - No Results Available Locations - Study designs - Allocation: Randomized\|Intervention Model: Parallel Assignment\|Masking: None (Open Label)\|Primary Purpose: Treatment Enrollment - 0 Age - 18 Years and older (Adult, Older Adult) Outcome measures - Hospitalization
NCT04324463	Anti-Coronavirus Therapies to Prevent Progression of Coronavirus Disease 2019 (COVID-19) Trial	Active, not recruiting	Phase 3	Apr/21/2020	Oct/01/2022
Alternative id - PHRI.ACT.COVID19 Interventions - Drug: Colchicine\|Drug: Interferon-Beta\|Drug: Aspirin\|Drug: Rivaroxaban Study type - Interventional Study results - No Results Available Locations - Hospital Adventista de Manaus, Manaus, Amazonas, Brazil\|Prodal Saude S/A, Salvador, BA, Brazil\|Hospital das Clinicas de Vitoria (Hospital Universitario Cassiano Antonio Moraes), Vitoria, ES, Brazil\|Ubermed Serviços em Saúde Eireli - Hospital São Domingos, Uberaba, MG, Brazil\|Hospital de Clínicas da Universidade Federal de Uberlândia, Uberlândia, MG, Brazil\|Hospital Universitario Julio Muller, Cuiabá, Mount, Brazil\|Instituto Tacchini de Pesquisa em Saude / Hospital Tacchini, Bento Goncalves, Rio Grande Do Sul, Brazil\|Santa Casa de Votuporanga, Votuporanga, Sao Paulo, Brazil\|Hospital Universitario Prof. Dr. Horacio Carlos Panepucci da Universidade Federal de Sao Carlos (HU-UFSCar), São Carlos, SP, Brazil\|Hospital Alemão Oswaldo Cruz, São Paulo, SP, Brazil\|CardiAI Inc., Calgary, Alberta, Canada\|Hamilton Health Sciences, Hamilton, Ontario, Canada\|London Health Sciences Centre, London, Ontario, Canada\|Southlake Regional Health Centre, Newmarket, Ontario, Canada\|Halton Healthcare/Oakville Trafalgar Memorial Hospital, Oakville, Ontario, Canada\|Niagara Health System-St. Catharine's, St. Catharines, Ontario, Canada\|Toronto Western Hospital Family Health Team, Toronto, Ontario, Canada\|Windsor Regional Hospital, Windsor, Ontario, Canada\|Woodstock Hospital, Woodstock, Ontario, Canada\|CIUSSS de L'est-de-l'ile de Montreal, Hopital Maisonneuve-Rosemont, Montreal, Quebec, Canada\|Centre Hospitalier de l'Université de Montréal (CHUM), Montréal, Quebec, Canada\|Biomelab SAS, Barranquilla, Atlantico, Colombia\|Clinica de la Costa LTDA, Barranquilla, Atlantico, Colombia\|Instituto de Neumologico del Oriente, Bucaramanga, Santander, Colombia\|Unicormed, Guayaquil, Guayas, Ecuador\|Hospital de Especialidades Eugenio Espejo, Quito, Pichincha, Ecuador\|Hospital Enrique Garces, Quito, Pichincha, Ecuador\|Hospital General Pablo Arturo Suarez, Quito, Pichincha, Ecuador\|Oncoambato, Ambato, Tungurahua, Ecuador\|Giza Chest Hospital, Giza, Cairo, Egypt\|Abbasia Chest Hospital, Cairo, Egypt\|Abbasia Fever Hospital, Cairo, Egypt\|National Hepatology and Tropical Medicine Research Institute, Cairo, Egypt\|Fayoum University Hospital, Fayoum, Egypt\|St. John's Medical College and Hospital, Bangalore, Karnataka, India\|Bharathi Hospital and Research Center, Pune, Maharashtra, India\|Sanjeevan Hospital, Pune, Maharashtra, India\|Sidhu Hospital Pvt.Ltd, Doraha, Punjab, India\|SRM Medical College Hospital & Research Center, Chengalpattu, Tamil Nadu, India\|AIG Hospital, Hyderabad, Telangana, India\|KIMS, Secunderabad, Telangana, India\|Chitwan Medical College, Bharatpur-10, Bagmati, Nepal\|Sahid Gangalal National Heart Center, Kathmandu, Bagmati, Nepal\|Province Hospital, Karnali Province, Surkhet, Karnali, Nepal\|Mechi Zonal Hospital, Bhadrapur, Province No. 1, Nepal\|Koshi Zonal Hospital, Biratnagar, Province No. 1, Nepal\|B.P. Koirala Institute of Health Sciences, Kathmandu, Province No.1, Nepal\|Aga Khan University Hospital, Karachi, Sindh, Pakistan\|Jinnah Postgraduate Medical Center, Karachi, Sindh, Pakistan\|Tabba Heart Institute, Karachi, Sindh, Pakistan\|Philippine General Hospital, Manila, Metro Manila, Philippines\|State Budgetary Health Care Institution of Sverdlovsk region "Central city clinical hospital # 6 Ekaterinburg", Ekaterinburg, Sverdlovsk Region, Russian Federation\|Central City Clinical Hospital No. 24, Yekaterinburg, Sverdlovsk Region, Russian Federation\|Tver State Medical University, Tver, Tver Oblast, Russian Federation\|Voronezh State Medical University named after N.N. Burdenko, Voronezh, Voronezh Region, Russian Federation\|Altai Regional Center for Medical Prevention, Barnaul, Russian Federation\|City Clinical Hospital No. 15 named after O.M. Filatova, Moscow, Russian Federation\|National Medical Research Center for Therapy and Preventive Medicine, Moscow, Russian Federation\|City Clinical Hospital No. 3, Nizhny Novgorod, Russian Federation\|Rostov State Medical University, Rostov-on-Don, Russian Federation\|Tiervlei Trial Centre, Cape Town, Western Cape, South Africa\|University of Cape Town- Groote Schuur Hospital, Cape Town, Western Cape, South Africa\|TASK Eden, George, Western Cape, South Africa\|Hatta Hospital, Hatta, Dubai, United Arab Emirates\|Rashid Hospital, Dubai Health Authority, Dubai, United Arab Emirates\|Thumbay Hospital Dubai, Dubai, United Arab Emirates Study designs - Allocation: Randomized\|Intervention Model: Parallel Assignment\|Masking: None (Open Label)\|Primary Purpose: Treatment Enrollment - 6667 Age - 18 Years and older (Adult, Older Adult) Outcome measures - Outpatient trial - Colchicine vs. control: Time from randomization to first occurrence of the composite of hospitalization or death\|Outpatient trial - Aspirin vs. control: Time from randomization to first occurrence of the composite of hospitalization, death or major thrombosis (MI, stroke, ALI, or PE)\|Inpatient trial - Colchicine vs. control: Time from randomization to first occurrence of the composite of high flow oxygen, mechanical ventilation, or death\|Inpatient trial - Aspirin and Rivaroxaban vs. control: Time from randomization to first occurrence of the composite of high flow oxygen, mechanical ventilation, death or major thrombosis (MI, stroke, ALI, or PE)\|Outpatient trial - Aspirin vs. control: Time from randomization to first occurrence of any thrombosis (MI, stroke, ALI, PE, or DVT)\|Inpatient trial - Colchicine vs. control: Time from randomization to first occurrence of the composite of high flow oxygen, mechanical ventilation, or respiratory death\|Inpatient trial - Aspirin vs. control: Time from randomization to first occurrence of the composite of high flow oxygen, mechanical ventilation, or respiratory death\|Inpatient trial - Aspirin vs. control: Time from randomization to first occurrence of any thrombosis (MI, stroke, ALI, PE, or DVT)
NCT04381936	Randomised Evaluation of COVID-19 Therapy	Recruiting	Phase 2\|Phase 3	Mar/19/2020	Nov/01/2032
Alternative id - NDPHRECOVERY\|2020-001113-21\|ISRCTN50189673 Interventions - Drug: Lopinavir-Ritonavir\|Drug: Corticosteroid\|Drug: Hydroxychloroquine\|Drug: Azithromycin\|Biological: Convalescent plasma\|Drug: Tocilizumab\|Biological: Immunoglobulin\|Drug: Synthetic neutralising antibodies\|Drug: Aspirin\|Drug: Colchicine\|Drug: Baricitinib\|Drug: Anakinra\|Drug: Dimethyl fumarate\|Drug: High Dose Corticosteroid\|Drug: Empagliflozin\|Drug: Sotrovimab Study type - Interventional Study results - No Results Available Locations - Kumasi Center for Collaborative Research in Tropical Medicine KNUST, Kumasi, Ghana\|Indian Council of Medical Research, Division of Epidemiology and Communicable Diseases, New Delhi, India\|Eijkman Oxford Clinical Research Unit (EOCRU), Eijkman Institute for Molecular Biology, Jakarta, Indonesia\|Clinical Trial Unit, Oxford University Clinical Research Unit-Nepal, Patan Academy of Health Sciences, Kathmandu, Nepal\|Wits Health Consortium, Johannesburg, South Africa\|RECOVERY Sri Lanka & Pakistan, National Intensive Care Surveillance - M.O.R.U, Colombo, Sri Lanka\|Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom\|Oxford University Clinical Research Unit, Centre for Tropical Medicine, Ho Chi Minh City, Vietnam Study designs - Allocation: Randomized\|Intervention Model: Factorial Assignment\|Masking: None (Open Label)\|Primary Purpose: Treatment Enrollment - 50000 Age - Child, Adult, Older Adult Outcome measures - All-cause mortality\|Duration of hospital stay\|Composite endpoint of death or need for mechanical ventilation or ECMO
NCT04498273	COVID-19 Positive Outpatient Thrombosis Prevention in Adults Aged 40-80	Terminated	Phase 3	Sep/07/2020	Aug/05/2021
Alternative id - ACTIV4-Outpatient Interventions - Drug: Apixaban 2.5 MG\|Drug: Apixaban 5MG\|Drug: Aspirin\|Drug: Placebo Study type - Interventional Study results - Has Results Locations - University of Southern California, Los Angeles, California, United States\|Stanford University School of Medicine, Palo Alto, California, United States\|Zuckerberg San Francisco General, San Francisco, California, United States\|Olive View-UCLA Medical Center, Sylmar, California, United States\|Pine Ridge Family Medicine, Colorado Springs, Colorado, United States\|Life Tree Health, Inc., Washington, District of Columbia, United States\|Midland Florida Clinical Research Center, LLC, DeLand, Florida, United States\|University of Florida at Gainesville, Gainesville, Florida, United States\|Vital Pharma Research, Hialeah, Florida, United States\|Advanced Research for Health Improvement, LLC, Immokalee, Florida, United States\|University of Floridia at Jacksonville, Jacksonville, Florida, United States\|Lakeland Regional, Lakeland, Florida, United States\|Total Research Group LLC, Miami, Florida, United States\|Jackson Memorial, Miami, Florida, United States\|Well Pharma Medical Research, Miami, Florida, United States\|Innovation Clinical Trials, Palmetto Bay, Florida, United States\|Bond Community Health Center, Tallahassee, Florida, United States\|Tallahassee Memorial, Tallahassee, Florida, United States\|USF Tampa General Hospital, Tampa, Florida, United States\|Alliance Clinical Research, Tampa, Florida, United States\|Hawaii Pacific Health, Honolulu, Hawaii, United States\|Fox Valley Clinical Research Center, LLC, Aurora, Illinois, United States\|UIC - Mile Square, Chicago, Illinois, United States\|Jesse Brown VA, Chicago, Illinois, United States\|University of Illinois at Chicago, Chicago, Illinois, United States\|Olivo Wellness Medical Center, Chicago, Illinois, United States\|University of Chicago, Chicago, Illinois, United States\|OSF Saint Francis Medical Center, Peoria, Illinois, United States\|Ascension Via Christi, Wichita, Kansas, United States\|University Medical Center New Orleans, New Orleans, Louisiana, United States\|Jadestone Clinical Research, LLC, Gaithersburg, Maryland, United States\|Brigham & Women's Hospital, Boston, Massachusetts, United States\|GFC of Southeastern Michigan, Detroit, Michigan, United States\|SRI International, Plymouth, Michigan, United States\|Metro Health-University of Michigan Health, Wyoming, Michigan, United States\|Raritan Bay Primary Care and Cardiology Associates, Matawan, New Jersey, United States\|G&S Medical Associates, LLC, Paterson, New Jersey, United States\|University of New Mexico, Albuquerque, New Mexico, United States\|Montefiore Medical Center, Bronx, New York, United States\|Strong Memorial, Rochester, New York, United States\|Spinal Pain and Rehab Medicine, Yonkers, New York, United States\|Duke, Durham, North Carolina, United States\|Peters Medical Research, High Point, North Carolina, United States\|The Heart and Medical Center, Durant, Oklahoma, United States\|Ascension St. John Clinical Research Institute, Tulsa, Oklahoma, United States\|UPMC Passavant Cranberry, Cranberry, Pennsylvania, United States\|UPMC McKeesport, McKeesport, Pennsylvania, United States\|UPMC East, Monroeville, Pennsylvania, United States\|UPMC Magee, Pittsburgh, Pennsylvania, United States\|UPMC Presby, Pittsburgh, Pennsylvania, United States\|UPMC Mercy, Pittsburgh, Pennsylvania, United States\|Preferred Primary Care Physicians, Pittsburgh, Pennsylvania, United States\|UPMC Shadyside, Pittsburgh, Pennsylvania, United States\|UPMC Passavant McCandless, Pittsburgh, Pennsylvania, United States\|Preferred Primary Care Physicians, Inc, Pittsburgh, Pennsylvania, United States\|Preferred Primary Care Physicians, Pittsburgh, Pennsylvania, United States\|Preferred Primary Care Physicians, Uniontown, Pennsylvania, United States\|Pharma Tex Research, Amarillo, Texas, United States\|Ascension Seton Medical Center, Austin, Texas, United States\|Baptist Beaumont, Beaumont, Texas, United States\|McGoven Medical School - UT- Houston, Houston, Texas, United States\|Diversifield Medical Practices, Houston, Texas, United States\|Next Level Urgent Care, Houston, Texas, United States\|Mesquite Regional Internal Medicine, Mesquite, Texas, United States\|University of Texas at Tyler, Tyler, Texas, United States\|University of Texas at Rio Grande Valley, Weslaco, Texas, United States\|Intermountain Healthcare, Murray, Utah, United States\|Community Care of Clay, Clay, West Virginia, United States\|University Healthcare Physicians, Harpers Ferry, West Virginia, United States\|Community Care of Weston, Weston, West Virginia, United States\|Gundersen Health System, La Crosse, Wisconsin, United States Study designs - Allocation: Randomized\|Intervention Model: Parallel Assignment\|Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)\|Primary Purpose: Prevention Enrollment - 657 Age - 40 Years to 80 Years (Adult, Older Adult) Outcome measures - Hospitalization for Cardiovascular/Pulmonary Events
NCT04768179	Safety & Efficacy of Low Dose Aspirin / Ivermectin Combination Therapy for Treatment of Covid-19 Patients	Not yet recruiting	Phase 2\|Phase 3	Feb/19/2021	Sep/30/2021
Alternative id - IVCOM PROTOCOL VERSION 03 Interventions - Drug: 3-dayIVM 200 mcg/kg/day/14-day 75mgASA/day + standard of care (intervention 1) Study type - Interventional Study results - No Results Available Locations - Study designs - Allocation: Randomized\|Intervention Model: Parallel Assignment\|Masking: None (Open Label)\|Primary Purpose: Treatment Enrollment - 490 Age - 18 Years to 64 Years (Adult) Outcome measures - SARS COV 2 Viral clearance\|World Health Organization COVID-19 ordinal improvement score\|Clinical recovery\|Spectrum and severity of adverse events\|Maximum Plasma concentration\|Minimum Plasma concentration\|Area Under the Curve
NCT05073718	Acetylsalicylic Acid in COVID-19 (ASA-SARS)	Not yet recruiting	Phase 3	Jan/15/2022	Oct/01/2023
Alternative id - HCB/2021/0060 Interventions - Drug: Low-dose acetylsalicylic acid\|Drug: Placebo Study type - Interventional Study results - No Results Available Locations - Study designs - Allocation: Randomized\|Intervention Model: Parallel Assignment\|Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)\|Primary Purpose: Prevention Enrollment - 199 Age - Child, Adult, Older Adult Outcome measures - Rate of composite adverse maternal and perinatal adverse outcome including fetal death, preterm preeclampsia, maternal thromboembolic complications, placental abruption, preterm birth and small for gestational age.\|Prevalence of SARS-CoV-2 infection and COVID-19 disease during pregnancy\|Incidence of COVID-19-related admissions\|Incidence of all-cause admissions\|Incidence of all-cause outpatient attendances\|Mean duration of symptoms-signs of COVID-19\|Frequency and severity of adverse events\|Incidence of preeclampsia\|Incidence of maternal thromboembolic complications and placental abruption\|Maternal mortality rate\|Incidence of histological placental abnormalities in SARS-CoV-2 infected pregnant women.\|Prevalence of preterm birth (<37 weeks of gestational age)\|Prevalence of small for gestational age\|Prevalence of embryo and foetal losses (miscarriages and stillbirths)\|Proportion of adverse perinatal outcome\|Neonatal morbidity\|Neonatal mortality rate
NCT04368377	Enhanced Platelet Inhibition in Critically Ill Patients With COVID-19	Completed	Phase 2	Apr/06/2020	Apr/23/2020
Alternative id - 18275/2020 Interventions - Drug: Tirofiban Injection\|Drug: Clopidogrel\|Drug: Acetylsalicylic acid\|Drug: Fondaparinux Study type - Interventional Study results - No Results Available Locations - L. Sacco Hospital, Milano, Lombardia, Italy Study designs - Allocation: N/A\|Intervention Model: Single Group Assignment\|Masking: None (Open Label)\|Primary Purpose: Treatment Enrollment - 5 Age - 18 Years and older (Adult, Older Adult) Outcome measures - P/F ratio\|PaO2 difference\|A-a O2 difference\|CPAP duration\|In-hospital change in intensity of the respiratory support\|PaCO2 difference\|HCO3- difference\|Lactate difference\|Hb difference\|Plt difference\|Adverse effects
NCT04425863	Ivermectin, Aspirin, Dexamethasone and Enoxaparin as Treatment of Covid 19	Completed		May/01/2020	Aug/30/2020
Alternative id - IDEA Interventions - Drug: Ivermectin 5 MG/ML oral solution, Aspirin 250 mg tablets\|Other: Ivermectin 5 mg/mL oral solution, Dexamethasone 4-mg injection, Aspirin 250 mg tablets\|Other: Ivermectin 5 MG/ML oral solution, Dexamethasone 4-mg injection, Enoxaparin injection. Inpatient treatment with mechanical ventilation in ICU. Study type - Observational Study results - Has Results Locations - Hospital Eurnekian, Buenos Aires, Argentina Study designs - Observational Model: Cohort\|Time Perspective: Prospective Enrollment - 167 Age - 5 Years and older (Child, Adult, Older Adult) Outcome measures - Patients Who Improved Their Condition or Did Not Worsen it\|ICU-treated Patients After 2-week Treatment\|Mortality\|Patients Needing Drug Dose Adjustment\|Adverse Events
NCT04333407	Preventing Cardiac Complication of COVID-19 Disease With Early Acute Coronary Syndrome Therapy: A Randomised Controlled Trial.	Recruiting	Not Applicable	Apr/03/2020	Mar/30/2021
Alternative id - 20HH5868 Interventions - Drug: Aspirin 75mg\|Drug: Clopidogrel 75mg\|Drug: Rivaroxaban 2.5 MG\|Drug: Atorvastatin 40mg\|Drug: Omeprazole 20mg Study type - Interventional Study results - No Results Available Locations - Charing Cross Hospital, London, United Kingdom Study designs - Allocation: Randomized\|Intervention Model: Parallel Assignment\|Masking: None (Open Label)\|Primary Purpose: Treatment Enrollment - 3170 Age - 18 Years to 85 Years (Adult, Older Adult) Outcome measures - All-cause mortality at 30 days after admission\|Absolute change in serum troponin from admission to peak value\|Discharge Rate\|Intubation Rate
NCT04343001	Coronavirus Response - Active Support for Hospitalised Covid-19 Patients	Withdrawn	Phase 3	Oct/01/2020	Aug/01/2021
Alternative id - 2020-KEP-420 Interventions - Drug: Aspirin\|Drug: Losartan\|Drug: Simvastatin Study type - Interventional Study results - No Results Available Locations - University College Hospital, Ibadan, Oyo, Nigeria\|Shifa Tameer-e-Millat University, Rawalpindi, Pakistan Study designs - Allocation: Randomized\|Intervention Model: Factorial Assignment\|Masking: None (Open Label)\|Primary Purpose: Treatment Enrollment - 0 Age - 40 Years and older (Adult, Older Adult) Outcome measures - Death\|Myocardial infarction\|Congestive cardiac failure\|Severe cardiac arrythmia\|Myocarditis\|Respiratory failure including ARDS\|Viral pneumonitis\|Acute renal failure\|Sepsis\|Stroke\|Gastrointestinal bleeding\|Receipt of non invasive or mechanical ventilation\|Ability to self care at hospital discharge
NCT04808895	Acetylsalicylic Acid in the Prevention of Severe SARS-CoV2 Pneumonia in Hospitalised Patients With COVID-19	Not yet recruiting	Phase 3	Apr/01/2021	Aug/31/2021
Alternative id - EudraCT 2020-006130-12 Interventions - Drug: Acetylsalicylic acid\|Drug: Placebo Study type - Interventional Study results - No Results Available Locations - Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy Study designs - Allocation: Randomized\|Intervention Model: Parallel Assignment\|Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)\|Primary Purpose: Treatment Enrollment - 204 Age - 18 Years to 99 Years (Adult, Older Adult) Outcome measures - Prevention of clinical worsening\|Prevention of lung function worsening\|Prevention of death\|Change in body temperature\|Change in oxygen saturation\|Change in blood gases\|Change in blood cell count\|Change in blood oxygen\|Change in clinical markers of lung function\|Change in clinical markers of liver damage\|Change in clinical markers of hearth damage\|Change in clinical markers of renal damage\|Effects on blood cell count\|Effects on CRP\|Effects on D-dimer\|Effects on interleukin-1\|Effects on interleukin-6\|Effects on fibrinogen\|Effects on plasma albumin\|Effects on protrombin time\|Effects on activated partial thromboplastin time\|Effects on serum thromboxane\|Effects on thromboxane metabolite\|Effects on platelet count\|Effects on reticulated platelets\|Effects on platelet/leukocyte conjugates\|Effects on plasma P-selectin\|Effects on P-selectin expression\|Clincal mixed outcome of lung function, ROX score\|Clincal mixed outcome of lung function, SOfa score\|Clincal mixed outcome of lung function, Apache index\|Clincal mixed outcome of lung function, need to perform CT scan due to worsening of blood gases\|Clincal mixed outcome of lung function, need to transfer the patient to ICU\|Clincal mixed outcome of lung function, need for mechanical ventilation\|Clincal mixed outcome of lung function, days without need of mechanical ventilation\|Clincal mixed outcome of lung function, venous thromboembolism\|Clincal mixed outcome of lung function, pulmonary thrombosis\|Clincal mixed outcome of lung function, cardiovascular event\|Clincal mixed outcome of lung function, death\|Clincal mixed outcome of lung function, multiorgan failure\|Clincal mixed outcome of lung function, discharge due to resolution of signs and symptoms\|Safety outcomes, Major or clinically relevant bleeding\|Safety outcomes, total bleeding based on ISTH bleeding score\|Safety outcomes, minor bleeding according to ISTH BS\|Safety outcomes, decrease in platelet count below 100x109/L\|Safety outcomes, decrease of al least 2 g/dl Hb levels\|Safety outcomes, need for blood transfusion\|Safety outcomes, alterations of clinical or laboratory parameters

Export (.csv)